Die Wirkung von Invertseifen auf die durch Pilze und Kokken bedingten Hautkrankheiten

Kimmig, J; Jerchel, Dietrich

doi:10.1007/bf01485528

Cited by 20 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Quaternary phosphonium salts (QPSs) are similar in their structure and biological activity against microbes [ 23 , 24 ]. Their bactericidal activity and safety for humans were discovered in the middle of the 20th century [ 25 ] and continue to be studied [ 26 ]. Particularly intensive research on their biological activity has been spurred by the spread of the usage of phosphonium ionic liquids (PILs) in science and technology.…”

Section: Introductionmentioning

confidence: 99%

Sterically Hindered Quaternary Phosphonium Salts (QPSs): Antimicrobial Activity and Hemolytic and Cytotoxic Properties

Ermolaev

Arkhipova

Miluykov

et al. 2021

IJMS

View full text Add to dashboard Cite

Structure–activity relationships are important for the design of biocides and sanitizers. During the spread of resistant strains of pathogenic microbes, insights into the correlation between structure and activity become especially significant. The most commonly used biocides are nitrogen-containing compounds; the phosphorus-containing ones have been studied to a lesser extent. In the present study, a broad range of sterically hindered quaternary phosphonium salts (QPSs) based on tri-tert-butylphosphine was tested for their activity against Gram-positive (Staphylococcus aureus, Bacillus сereus, Enterococcus faecalis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria and fungi (Candida albicans, Trichophyton mentagrophytes var. gypseum). The cation structure was confirmed to determine their biological activity. A number of QPSs not only exhibit high activity against both Gram-positive and -negative bacteria but also possess antifungal properties. Additionally, the hemolytic and cytotoxic properties of QPSs were determined using blood and a normal liver cell line, respectively. The results show that tri-tert-butyl(n-dodecyl)phosphonium and tri-tert-butyl(n-tridecyl)phosphonium bromides exhibit both low cytotoxicity against normal human cells and high antimicrobial activity against bacteria, including methicillin-resistant strains S. aureus (MRSA). The mechanism of QPS action on microbes is discussed. Due to their high selectivity for pathogens, sterically hindered QPSs could serve as effective tunable biocides.

show abstract

Section: Introductionmentioning

confidence: 99%

Sterically Hindered Quaternary Phosphonium Salts (QPSs): Antimicrobial Activity and Hemolytic and Cytotoxic Properties

Ermolaev

Arkhipova

Miluykov

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Surface active compounds. Two surface active compounds were investigated: dodecyl-di(/?-oxyethyl)-bcnzene ammonium chloride (DOBAC) [3] and dodecyl-triphenyl phosphonium bromide (DTPB) [1,4,5], The compounds were dissolved in ethanol. In a first series of experiments, bactericidal concentrations of both surface active compounds were evaluated.…”

Section: Bacterial Organismsmentioning

confidence: 99%

The Influence of Corticosteroids on Antibacterial Activity of Surface Active Compounds

Raab

Windisch

1970

Chemotherapy

View full text Add to dashboard Cite

In vitro, antimicrobial activity of dodecyl-di(β- hydroxyethyl)-benzene ammonium chloride (DOBAC) and dodecyl-triphenyl-phosphonium bromide (DTPB), two surface active compounds, was tested in the presence of corticosteroids in doses which have been shown to enhance metabolic activity of bacteria. The experiments were performed with the Warburg technique measuring oxygen consumption of bacterial suspension in resting phase. Staph. aureus and B. pyocyaneus, three strains of each, served as test organisms. On Staph. aureus a marked decrease in antimicrobial activity of DOBAC and DTPB was encountered after addition of corticosteroids (hydrocortisone, methylprednisolone, fluocinolone). A similar, but weaker effect was present in B. pyocyaneus, too. These data suggest that in vitro tests should be performed before different chemotherapeutic are combined in one preparation.

show abstract

Phosphorus Compounds, Organic

Svara¹,

Weferling²,

Hofmann³

2000

Ullmann's Encyclopedia of Industrial Chemistry

View full text Add to dashboard Cite

Die Wirkung von Invertseifen auf die durch Pilze und Kokken bedingten Hautkrankheiten

Cited by 20 publications

References 2 publications

Sterically Hindered Quaternary Phosphonium Salts (QPSs): Antimicrobial Activity and Hemolytic and Cytotoxic Properties

Sterically Hindered Quaternary Phosphonium Salts (QPSs): Antimicrobial Activity and Hemolytic and Cytotoxic Properties

The Influence of Corticosteroids on Antibacterial Activity of Surface Active Compounds

Phosphorus Compounds, Organic

Contact Info

Product

Resources

About