Die Wirkung einiger Histamin-Chelatbildender Schwermetalle auf die Histaminkontraktion des Meerschweinchenileums

Eichler, Oskar; Th, Lippert

doi:10.1007/bf00246187

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…There have been several reports (Ambache, 1946;Eichler & Lippert, 1966) of the ability of trace metal ions to cause spasm of the guinea-pig isolated ileum preparation. Schnieden & Weston (1969) showed that manganese (in concentrations of 10' to 6-4 x 10-5M) is a spasmogen whose action is mediated via the release of acetylcholine from intramural nerves.…”

Section: Introductionmentioning

confidence: 99%

Spasmolytic effects of cadmium and zinc ions upon the guinea‐pig isolated ileum preparation

Schnieden

Small

1971

British J Pharmacology

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Summary1. An investigation has been made of the effects of cadmium and zinc ions upon the contractile response of the guinea-pig isolated ileum to methacholine, histamine, potassium ion and a.c. field stimulation. The metal ions depress the response to all of these agents. 2. Radioisotope studies showed that cadmium and zinc ions have very much larger apparent volumes of distribution than sorbitol, both within whole ileum and within strips of the longitudinal smooth muscle layer. The results of these studies were indicative of surface binding and/or intracellular accumulation of these ions. 3. It is suggested that cadmium and zinc ions directly depress smooth muscle contractility in a non-specific manner. This action may result from their binding to or accumulation within the muscle cells.

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Section: Introductionmentioning

confidence: 99%

Spasmolytic effects of cadmium and zinc ions upon the guinea‐pig isolated ileum preparation

Schnieden

Small

1971

British J Pharmacology

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“…While this work was in progress a paper appeared (Eichler, Lippert, 1966) suggesting the effect of zinc on histamine was due to chelation hut since we also obtain inhibitory effects on S.R.S. responses we cannot hold this view.…”

Section: Discussionmentioning

confidence: 75%

Inhibition of Histamine Response by Zinc

Trethewie¹

1968

Pharmacology

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“…Eichler and Lippert (1966) have shown that spasms of the guinea-pig ileum can (be produced by cobalt, nickel, copper and zinc. In addition, Ba++ (100-500 ,LM) has long been known to be a potent spasmogen and the action of this metal has been shown to possess a considerable neurogenic component (Ambache, 1946;Amibache & Lessin, 1955;Gershon, 1967 ;Paton & Zar, 1968).…”

Section: Discussionmentioning

confidence: 99%

Investigation of the spasmogenic effect of manganese on the guinea‐pig isolated ileum preparation

Schnieden

Weston

1969

British J Pharmacology

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1. The mechanism of the manganese-induced spasm of the guinea-pig ileum was investigated using agents known to modify nerve function. The spasm was reduced by cooling, tetrodotoxin, procaine, Botulinus toxin (Type A), hyoscine and pempidine. It was potentiated by mipafox. 2. In the presence of manganese, the release of acetylcholine from the ileum was greatly increased. 3. Tetrodotoxin prevented the manganese-induced increase in acetylcholine output from the ileum but had no significant effect on the spontaneous acetylcholine output. 4. It is suggested that the manganese-induced spasm of the ileum results from an action on intramural cholinergic nerves.During an investigation of the effect of manganese on the responses of the guineapig isolated ileum preparation to various drugs, it was found that manganese itself, in concentrations ranging from 4 to 64 gM produced a marked spasm of the ileum. This paper presents the results of experiments by which the mechanism of this spasmogenic effect was investigated. A preliminary account of these experiments was communicated to the British Pharmacological Society at the Cardiff Meeting (Schnieden & Weston, 1968). MethodsGuinea-pigs of either sex and weighing 250-450 g were killed by stunning and bleeding. A segment of ileum 2.5 cm in length and situated about 15 cm proximal to the ileo-caecal junction was used. The tissue was set up in a 10 ml. organ bath containing Krebs solution maintained at 370 C and bubbled with a mixture of 95% oxygen and 5% carbon dioxide. Tension changes of the ileum were recorded with a force displacement transducer and pen recorder; the tissue was connected to the transducer with terylene thread.The transducer was supported in a rack work X>block which allowed the resting tension of the ileum to be changed smoothly. The load was initially fixed at 0.5 g but the ileum stretched, lowering the tension in the system. The tissue was washed with Krebs solution at 4 min intervals and the load was adjusted to 0.5 g after each wash. After six to twelve washes, a fairly stable baseline was achieved and the rate of relaxation did not exceed the equivalent of 0.05 g/hr.

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Die Wirkung einiger Histamin-Chelatbildender Schwermetalle auf die Histaminkontraktion des Meerschweinchenileums

Cited by 5 publications

References 5 publications

Spasmolytic effects of cadmium and zinc ions upon the guinea‐pig isolated ileum preparation

Spasmolytic effects of cadmium and zinc ions upon the guinea‐pig isolated ileum preparation

Inhibition of Histamine Response by Zinc

Investigation of the spasmogenic effect of manganese on the guinea‐pig isolated ileum preparation

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