Spasmolytic effects of cadmium and zinc ions upon the guinea‐pig isolated ileum preparation

Schnieden, H.; Small, R.C.

doi:10.1111/j.1476-5381.1971.tb08046.x

Cited by 31 publications

(11 citation statements)

References 13 publications

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“…[3H]-SUBSTANCE P METABOLISM IN (Figure 5), and yielded an extracellular space estimate of 44%, which is smaller than that reported by Schnieden & Small (1971) with the value of 34% reported by Goto, Masuda & Kasuya (1976) but considerably smaller than that reported by Egan, Graham & Lewis (1976) of 80%. The semi-log transformation of these data yielded a linear slope, which is consistent with diffusion into a single compartment.…”

Section: Resultscontrasting

confidence: 47%

Rapid degradation of [³H]‐substance P in guinea‐pig ileum and rat vas deferens in vitro

Watson¹

1983

British J Pharmacology

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1 The degradation of [3H]-substance P was monitored in guinea-pig ileum and rat vas deferens. Substantial and rapid metabolism occurred in both tissues within the time course of the pharmacological responses; for example, after 1 min more than 50% of the extracted tritium from both tissues was present in the form of metabolites. 2 [3H]-inulin was used to estimate the rate of equilibration of the extracellular space of guinea-pig ileum longitudinal muscle and rat vas deferens with the bath fluid; half-lives of 30 s and 5 min respectively were observed. 3 These two factors combine to give different concentrations of substance P in the biophase of the tissues. The peak concentration of substance P reached in the guinea-pig ileum longitudinal muscle was approximately five times higher than in the rat vas deferens. 4 An analogue of substance P, [3H]-DiMe-C7, was found to be stable in both tissues. 5 These results are discussed in the light of the suggested existence of multiple receptors for substance P, based on agonist potency differences.

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Section: Resultscontrasting

confidence: 47%

Rapid degradation of [³H]‐substance P in guinea‐pig ileum and rat vas deferens in vitro

Watson¹

1983

British J Pharmacology

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“…When the muscles were treated with medium containing 20 mM EDTA and subjected to the same experimental procedure, the results did not differ. EDTA, which does not penetrate the cell mem-'he mean of 10-12 brane of smooth muscle (Brading & Jones, 1969) and less than the size of whose action in aorta appears to be restricted to the cell membrane compartment (Weiss & Goodman, 1976) cle to several stimulant drugs (Schnieden & Small, 1971;Nasu, Koshiba, Mase & Ishida, 1983). The cadmium uptake by guinea-pig taenia coli reached an Lum containing difequilibrium level at 60 min; tissue content was L, 0.1 or 0.5mM).…”

Section: Effects Ofcd2+ On High-k+-induced Tension In Aortamentioning

confidence: 99%

Spasmolytic effect of cadmium and cadmium uptake in aorta

Nasu

1983

British J Pharmacology

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1The relationship between inhibition of tension by Cd2+ in aorta and the kinetics of cadmium uptake and efflux was studied. Cd2+ (0.01-0.5 mM) inhibited the contraction of aorta to high-K+ (30 mM) in a dose-dependent manner.2 The high-K+-induced tension completely returned to control values after 60 min washing with a solution containing 5 mM disodium edetate (EDTA) or 5 mM cysteine, following a treatment with 0.5 mM Cd2+ for 30 min; after washing with normal medium only 15% of the control response returned. 3 Cadmium uptake increased with an increase of the Cd2+ concentration (0.0 1-0.5 mM). 4 Aortae preincubated with 0.5 mM Cd2+ for 60 min were washed subsequently with a medium containing 5 mM EDTA or 5 mM cysteine. About 5 % of the original tissue cadmium was retained after washing with EDTA or cysteine. 5 It is suggested that Cd2+ binds chiefly to the surface membrane of aorta. It seems possible that the quantity bound is correlated with the degree of inhibition of tension.

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“…The main target organs for cadmium are the kidneys, liver, intestines, and the ileal longitudinal muscle [6][7][8]. It has been found to accumulate in the extracellular space of the guinea pig's tenia coli, inhibiting intestinal contractions [9].…”

Section: Introductionmentioning

confidence: 99%

Cadmium Reduces Contractile Responses of Rat Duodenum, In Vitro

Koç

Koçak

Akçıl

2008

Biol Trace Elem Res

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The present study focuses on the effects of cadmium in drinking water on rat duodenum contractility, in vitro. Two experimental groups (n = 10 each) were administered with 15 ppm cadmium chloride in their drinking water for 1 and 2 months, respectively. Two separate groups (n = 10 each) were maintained in similar conditions but received no cadmium and acted as controls. After the experimental period, the duodenal segment responses were measured by means of an isotonic transducer. The average peak amplitude of acetylcholine-induced contractions was significantly decreased in both cadmium-treated groups. Incubation of duodena from the cadmium-free controls with atropine or in a calcium-free medium resulted in reduced contractility that was undistinguishable from that of the cadmium-treated rats. Cadmium reduces the contractile response apparently by directly or indirectly decreasing cellular calcium influx.

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Spasmolytic effects of cadmium and zinc ions upon the guinea‐pig isolated ileum preparation

Cited by 31 publications

References 13 publications

Rapid degradation of [³H]‐substance P in guinea‐pig ileum and rat vas deferens in vitro

Rapid degradation of [³H]‐substance P in guinea‐pig ileum and rat vas deferens in vitro

Spasmolytic effect of cadmium and cadmium uptake in aorta

Cadmium Reduces Contractile Responses of Rat Duodenum, In Vitro

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Spasmolytic effects of cadmium and zinc ions upon the guinea‐pig isolated ileum preparation

Cited by 31 publications

References 13 publications

Rapid degradation of [3H]‐substance P in guinea‐pig ileum and rat vas deferens in vitro

Rapid degradation of [3H]‐substance P in guinea‐pig ileum and rat vas deferens in vitro

Spasmolytic effect of cadmium and cadmium uptake in aorta

Cadmium Reduces Contractile Responses of Rat Duodenum, In Vitro

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Rapid degradation of [³H]‐substance P in guinea‐pig ileum and rat vas deferens in vitro

Rapid degradation of [³H]‐substance P in guinea‐pig ileum and rat vas deferens in vitro