Die Wirksamkeit psychotherapeu-tischer Maßnahmen bei Morbus Crohn - Ergebnisse einer randomisierten, multizentrischen Studie1 -

Wietersheim, Jörn von; Scheib, Peter; Keller, Wolfram; Osborn, Walter; Pritsch, Maria; Balck, Friedrich; Fritzsche, Kurt; Dilg, Reiner; Schmelz-Schumacher, Eva

doi:10.1055/s-2001-10029

Cited by 6 publications

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References 5 publications

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“…A number of high quality studies have shown a link between the patient's psyche and the course of the disease [ 5 , 13 , 14 ]. However, when psychological treatment in the form of psychotherapy is given most randomized controlled trials in IBD patients have found it to be ineffective [ 15 - 19 ]. Thus, some investigators have proposed that treating psychological co-morbidities with antidepressants might be of more utility to control disease activity and lengthen remission, particularly in Crohn's disease patients [ 20 - 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Mikocka‐Walus

Turnbull

Moulding

et al. 2006

Clin Pract Epidemiol Ment Health

101

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BackgroundA number of studies have suggested a link between the patient's psyche and the course of inflammatory bowel disease (IBD). Although pharmacotherapy with antidepressants has not been widely explored, some investigators have proposed that treating psychological co-morbidities with antidepressants may help to control disease activity. To date a systematic analysis of the available studies assessing the efficacy of antidepressants for the control of somatic symptoms in IBD patients has not been performed.MethodsWe searched electronic databases, without any language restriction. All relevant papers issued after 1990 were examined.Results12 relevant publications were identified. All of them referred to non-randomised studies. Antidepressants reported in these publications included paroxetine, bupropion, amitriptyline, phenelzine, and mirtazapine. In 10 articles, paroxetine, bupropion, and phenelzine were suggested to be effective for treating both psychological and somatic symptoms in patients suffering from IBD. Amitriptyline was found ineffective for treating somatic symptoms of IBD. Mirtazapine was not recommended for IBD patients.ConclusionAlthough most of reviewed papers suggest a beneficial effect of treatment with antidepressants in patients with IBD, due to the lack of reliable data, it is impossible to judge the efficacy of antidepressants in IBD. Properly designed trials are justified and needed based upon the available uncontrolled data.

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Section: Introductionmentioning

confidence: 99%

Untitled

Mikocka‐Walus

Turnbull

Moulding

et al. 2006

Clin Pract Epidemiol Ment Health

101

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Controversies surrounding the comorbidity of depression and anxiety in inflammatory bowel disease patients

Mikocka‐Walus

Turnbull

Moulding

et al. 2007

Inflammatory Bowel Diseases

298

321

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Psychological disorders are highly prevalent in patients with inflammatory bowel disease (IBD). Anxiety and depression are known to independently affect quality of life and may additionally impair quality of life in IBD over and above the IBD itself. Some researchers have further proposed that anxiety and depression may influence the clinical course of IBD. However, despite the potential for anxiety and depression to play an important role in the clinical picture of IBD, there is little prospective well-controlled research in this area. Probably because of this lack of clear data, researchers dispute the actual role of these psychological disorders in IBD, with a number of conflicting opinions expressed. This article reports on a review of the literature in this field. Herein we discuss the five main areas of controversy regarding IBD and the specific psychological comorbidities of depression and anxiety: 1) the relative rate of cooccurrence of these psychological disorders with IBD; 2) the cooccurrence of these psychological disorders with particular phase of IBD; 3) the cooccurrence of these psychological disorders with the specific type of IBD; 4) the rate of these psychological comorbidities compared both to healthy subjects and to other disease states; and 5) the timing of onset of psychological comorbidity with respect to onset of IBD. Methodological weaknesses of the reviewed studies make it impossible to resolve these controversies. However, the results clearly show that anxiety/depression and IBD frequently interact. Given the long-term illness burden patients with IBD face, further prospective, appropriately controlled studies are needed to adequately answer the question of the precise interplay between anxiety/depression and IBD.

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Serie: psychologische interventies bij somatische aandoeningen

Albersnagel¹,

Dijkstra²

2007

PSEG

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Inflammatory Bowel Disease. Medical and psychological aspects A review is presented in which the state of the art of behavioural-scientific research on inflammatory bowel disease (IBD) is sorted out. After a short introduction on medical aspects of the two diseases that constitute IBD, i.e. Crohn's disease and ulcerative colitis, the factors that may have an influence on the quality of life of IBD patients are outlined: disease activity, quality of care, mental state and personality aspects, life events and actual circumstances, and social support. In addition, attempts to assist IBD patients to handle their 'concerns' are described, insofar (controlled) research literature permits. The following topics are covered: stress, anxiety, depression, coping and communication; fatigue; smoking cessation and (non-)adherence. In closing, some recommendations are presented that may have relevance, especially for prevention. InleidingTot de inflammatoire darmziekten (Inflammatory Bowel Disease, IBD) worden twee ziektebeelden gerekend: de ziekte van Crohn (M. Crohn) en colitis ulcerosa (CU). Tussen deze (chronische) ziektebeelden bestaan overeenkomsten en verschillen. Wat de (medische) klachten betreft is er bij CU bijna altijd sprake van frequente, dunne stoelgang (diarree); bij M. Crohn is dat vaak het geval. Ook is er bij CU bijna altijd bloed of slijm bij de ontlasting; bij M. Crohn speelt dat soms. Verder komen bij M. Crohn buikpijn, gewichtsverlies en moeheid/te weinig energie vaak voor; bij CU soms. Ook rapporteren M. Crohn patie¨nten vaak klachten rond de anus, wat bij CU patie¨nten zeldzaam is. Bij medisch onderzoek en diagnostiek is ontsteking van de dunne en/of dikke darm karakteristiek voor M. Crohn, waar het bij CU uitsluitend gaat om ontsteking van (een deel) van de dikke darm. Bij CU is sprake van een aaneensluitende ontsteking van de dikke darm die zich beperkt tot de oppervlakkige slijmvlieslaag van de dikke darm. Bij M. Crohn slaat de ontsteking vaak een stuk over (skip lesions) maar is wel de gehele darmwand (transmuraal) bij de ontsteking betrokken. Een dergelijke transmurale ontsteking kan aanleiding geven tot perforaties, abcessen of weefselgangetjes (fistels) tussen de darm en andere organen (huid, vagina, blaas, ander stuk darm)

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Die Wirksamkeit psychotherapeu-tischer Maßnahmen bei Morbus Crohn - Ergebnisse einer randomisierten, multizentrischen Studie1 -

Cited by 6 publications

References 5 publications

Untitled

Untitled

Controversies surrounding the comorbidity of depression and anxiety in inflammatory bowel disease patients

Serie: psychologische interventies bij somatische aandoeningen

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