Die wirksamen Alkaloide des Mutterkorns

Dale, H. H.; Spiro, K.

doi:10.1007/bf01863071

Cited by 49 publications

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“…The phenomenon, as it was habitually observed in such preparations, is illustrated in Figs. 10 A and 11 A. In considering the nature of this pressor effect, we naturally had in mind the double action of histamine, as shown on the vessels of the perfused organ.…”

Section: Part II Effects Observed With Natural Circulationmentioning

confidence: 99%

The vaso‐dilator action of histamine, and its physiological significance

Burn¹,

Dale²

1926

The Journal of Physiology

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177

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THE histamine paradox, which has been the subject of much discussion, may be stated thus briefly. In the cat, which has been the usual subject for experiment on its action, histamine regularly produces, under ansesthesia, a powerful depressor effect, having all the characteristics of a general vaso-dilatation; in perfused organs from the same species histamine has been found habitually to produce, not vaso-dilatation, but vaso-constriction in its place. Explanations of widely different kinds have been offered for this paradox. Dale and Richards(i) satisfied themselves that the effect seen in the anasthetised cat was a true, peripheral vaso-dilatation, independent of the nervous system. They explained the paradox by the incidence of the effect on the capillaries rather than the arteries, and showed that, under appropriate conditions (presence of blood corpuscles and adrenaline), the vaso-dilator effect could be demonstrated even on the artificially perfused organs of the cat. Other observers have attempted to explain it by supposing that the depressor effect seen in vivo was not due to vaso-dilatation. Thus Mautner and Pick(2) attributed it to constriction of hepatic venules. McDowall(3), while admitting capillary dilatation as a factor in the effect, has suggested that constriction of pulmonary arterioles is the earliest and principal agent in the depressor action. Inchley(4) has attributed the effect to constriction of the venules.In the present paper we present the results of observations undertaken primarily to complete those of Dale and Richards. It was important to know whether the action of adrenaline, mentioned above, was a specific one, or whether other vaso-constrictor agents could replace it, in creating a condition favourable to the vaso-dilator effect of histamine in artificial perfusion. The observations have been extended to other species, and some further experiments have been made on the effects seen with natural circulation.13-2

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Section: Part II Effects Observed With Natural Circulationmentioning

confidence: 99%

The vaso‐dilator action of histamine, and its physiological significance

Burn¹,

Dale²

1926

The Journal of Physiology

Self Cite

177

View full text Add to dashboard Cite

show abstract

“…In a second series of experiments, therefore, each rabbit was given a preliminary dose of 3 mgms. ergotamine tartrate, which has been shown by Dale and Spiro to have the same pharmacological action as ergotoxine (9). One hour later guanidine was injected and blood-sugar estimations carried out as before.…”

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confidence: 99%