Interrelation of parathyroids, suprarenals and pancreas

Clark, Gregory A.

doi:10.1113/jphysiol.1924.sp002130

Cited by 21 publications

(4 citation statements)

References 6 publications

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“…More recently Daniel & Henderson (1975) showed that the release of insulin in response to exogenous glucose in anaesthetized Rhesus monkeys is reduced by about 45 % following the administration of atropine. Clark (1924Clark ( , 1925 originally reported that the hypoglycaemic effect of drugs which stimulate the parasympathetic system is blocked by atropine in the conscious rabbit, while Etcheverry (1973a, b) showed that recovery from both hyperglycaemia (induced by the administration of exogenous glucose) and insulin hypoglycaemia is delayed after vagotomy or pancreatic denervation. Hell & Pupo (1979) failed to find any significant difference between the changes in mean plasma insulin concentration in response to exogenous glucose before and after vagotomy in the dog.…”

Section: Discussionmentioning

confidence: 99%

The role of the parasympathetic system in the control of insulin release in the conscious calf.

Bloom¹,

Edwards²

1981

The Journal of Physiology

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SUMMARY1. The effect of atropine (0-2 mg/kg) on the release of insulin from the pancreas, in response to both exogenous and endogenous hyperglycaemia, has been investigated in conscious 2-to 5-week-old calves.2. The rise in mean plasma insulin concentration in response to infusions ofglucose, which raised the concentration of glucose in the plasma by about 4 0 mmol/l, was significantly depressed in calves with cut splanchnic nerves by prior administration of atropine.3. The rise in plasma insulin concentration, which normally follows stimulation of the splanchnic nerves in the conscious calf , was almost completely suppressed by prior administration of atropine.4. These findings are discussed in relation to those of other workers with other species. The results indicate that the parasympathetic innervation to the pancreas plays an important part in the control ofinsulin release in response to hyperglycaemia.

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Section: Discussionmentioning

confidence: 99%

The role of the parasympathetic system in the control of insulin release in the conscious calf.

Bloom¹,

Edwards²

1981

The Journal of Physiology

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“…Numerous studies have implicated the parasympathetic innervation to the pancreatic islets in the release of insulin which occurs in response to hyperglycaemia in various species (Clark, 1924(Clark, , 1925Etcheverry, 1937 a, b;Daniel & Henderson, 1975; Bloom & Edwards, 1981) and are strongly supported by Niijima's finding that hyperglycaemia rapidly produces a substantial increase in the rate of firing of fibres in the pancreatic branch of the vagus nerve (Niijima, 1974a,b). In conscious calves, in which both splanchnic nerves had previously been cut, thereby eliminating both the depressant effects of anaesthesia and any effects which might be mediated via the sympathetic innervation, release of insulin in response to either exogenous or endogenous glucose is almost completely suppressed by prior administration of atropine (Bloom & Edwards, 1981).…”

Section: Introductionmentioning

confidence: 98%

Effects of the autonomic system on insulin release in response to exogenous glucose in weaned lambs.

Bloom¹,

Edwards²

1982

The Journal of Physiology

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SUMMARY1. The role of the autonomic innervation to the pancreas in mediating the release of insulin in response to exogenous glucose has been investigated in conscious weaned lambs 4-5 months after birth.2. The incremental rise in mean plasma insulin concentration was consistently lower in lambs with cut splanchnic nerves, which had been pre-treated with atropine (02 mg kg-'), than in normal control lambs, although the differences did not achieve statistical significance. 3. Pre-treatment with propranolol (0-25 mg kg-') effectively suppressed release of insulin in response to exogenous glucose in atropinized lambs with intact splanchnic nerves, but not in atropinized lambs with cut splanchnic nerves.4. The rise in mean plasma insulin concentration was significantly greater in lambs pre-treated with atropine (02 mg kg-') and phentolamine (01 mg kg-' initially, followed by 002 mg kg-' min-') than in atropinized lambs with cut splanchnic nerves.5. It is concluded that release of insulin in response to exogenous glucose is normally modified by both sympathetic a-adrenergic inhibition and fl-adrenergic excitation in this species.

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“…The urine at that time was found to contain sugar and, while none of the cardinal symptoms of diabetes April, 1926. existed, a qualitative dietary restriction was instituted. The diet was soon discontinued, and when we made our examina¬ tion in January, 1925, the fasting blood sugar was normal ; one specimen of the urine was sugar-free, while others showed traces of sugar.…”

Section: Report Of Casementioning

confidence: 99%

“…In March, 1926, Blood sugar was not determined during the coma, but a test meal of dextrose was given later and the results of this on the blood sugar as well as other data were presented by Dr. Ulrich at the meeting of the Minnesota Society of Internal Medicine, held in Rochester in November, 1926 (table 1).…”

Section: Report Of Casementioning

confidence: 99%