Die Weiblichen Sexualhormone

Clauberg, C.

doi:10.1007/978-3-662-28867-2

Cited by 67 publications

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“…* Address correspondence to this author at the Laboratoire d'Hormonologie, Hopital de Bicetre, 94275 Le Kremin-Bicetre Cedex, France. basis of the classical tests of Clauberg (Clauberg, 1933) and McGinty (McGinty et al, 1939).…”

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A novel progesterone-induced messenger RNA in rabbit and human endometria. Cloning and sequence analysis of the complementary DNA

Misrahi

Atger²,

Milgröm³

1987

Biochemistry

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Complementary DNAs (cDNAs) prepared from messenger RNAs (mRNAs) isolated from endometria of 5 day pregnant rabbits were inserted into the plasmid pBR322. A library of 2400 recombinant plasmid clones was prepared and screened by differential in situ hybridization with cDNAs prepared from mRNAs of rabbits either injected with progesterone or untreated by the hormone. Clones encoding uteroglobin were identified and discarded. Several progesterone-induced and progesterone-repressed clones were identified. One of them corresponded to a relatively frequent mRNA (0.2% of clones in the library) of 2300 nucleotides. The induction of this messenger RNA by progesterone was totally suppressed by the antagonist RU486. This compound displayed a limited agonistic activity when administered alone. A very small increase in mRNA concentration was observed after estradiol administration. The messenger RNA was also found in the liver (where it was constitutively expressed), the ovaries, and the Fallopian tubes of rabbits. A cross-hybridizing messenger RNA was detected in human endometrium during the luteal phase. Sequence analysis showed that the messenger RNA encoded a protein of 370 amino acids with a calculated molecular weight of 40,800. A search in Genbank and National Biomedical Research Foundation data banks showed no identity or marked similarity with previously published DNA or protein sequences.

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confidence: 99%

A novel progesterone-induced messenger RNA in rabbit and human endometria. Cloning and sequence analysis of the complementary DNA

Misrahi

Atger²,

Milgröm³

1987

Biochemistry

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“…This necessarily sketchy treatment of a vast field of research may indicate that although great progress has already been made in analyzing the endocrine basis of the female sex rhythm, the final picture awaits the results of future investigations. Excellent summaries of the developments in this field may be found in English by Corner (32,34) and Hartman and Novak (64), and in German by Clauberg (26).…”

Section: Phases Of the Female Sex Cyclementioning

confidence: 97%

The female sex rhythm.

Seward¹

1934

Psychological Bulletin

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A review of the historical development and present status of the problem, with 167 citations. The vaginal smear technique, which has been found best, has brought out four phases in the female sex cycle throughout the mammalia; but the menstruation phenomenon in primates has not received final interpretations. The endocrinal basis of the cycle is not yet completely worked out. Effects of the female sex rhythm upon other phenomena have been determined in varying degrees of agreement: body temperature, metabolic rate, sensory functions, spontaneous activity, intensity of the sex drive and of sex desire, all seem to show some effect; while cardio-vascular changes, reflex actions, muscular strength, motor coordination, motor learning, and psychomotor efficiency, have each been studied with conflicting results.

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The Therapeutic Use of Estrogenic Substances

Novak¹

1935

JAMA

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Die Weiblichen Sexualhormone

Cited by 67 publications

References 0 publications

A novel progesterone-induced messenger RNA in rabbit and human endometria. Cloning and sequence analysis of the complementary DNA

A novel progesterone-induced messenger RNA in rabbit and human endometria. Cloning and sequence analysis of the complementary DNA

The female sex rhythm.

The Therapeutic Use of Estrogenic Substances

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