Die Ver�nderung der Konzentration von Hydroxyprolin im Plasma nach Anastomosen am Darm

Abstract

Hydroxyproline plasma levels were determined in 39 patients before and after operation of the gastrointestinal tract. In the immediate postoperative period a decreased collagen metabolism was detected. From the third and seventh postoperative day respectively a considerable increase of the plasma concentration prevailed to the termination of the measurement period. There was no significant difference in the quantitative change with regard to the type of operation, whereas there were differences in the time course of the reaction. These results support the theory that an injury induces an increase in collagen metabolism leading to an elevation of hydroxyproline plasma concentration.

Connective tissue response to major surgery and postoperative infection

“…There is also no extra leakage of PICP to the wound during the first postoperative day [23]. In fact, a decreased concentration of serum 4-hydroxyproline as a manifestation of decreased turnover of collagen for up to 3 days after major surgery has been found [25].…”

Perioperative changes in the plasma metabolome of patients receiving general anesthesia for pancreatic cancer surgery

“…This might indicate that surgical tissue manipulation stopped collagen turnover or that free hydroxyproline is excreted e.g., via urine. Venbrocks et al also described decreased plasma hydroxyproline levels directly after surgery but plasma concentrations increased after the 3rd postoperative day [ 45 ]. Since there is evidence that supplementation of hydroxyproline and collagen hydrolysates may improve wound healing [ 44 , 46 ], further studies are necessary to evaluate the further postoperative concentrations of hydroxyproline to determine whether supplementation of hydroxyproline might be a useful tool to improve postoperative wound healing.…”