Connective tissue response to major surgery and postoperative infection

Haukipuro, Kari; Melkko, Jukka; Risteli, Leila; Kairaluoma, Matti I.; Risteli, Juha

doi:10.1111/j.1365-2362.1992.tb01471.x

Cited by 27 publications

(14 citation statements)

References 24 publications

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“…However, serum levels of PICP and PINP also showed a tendency to increase in surgical controls. Following major abdominal surgery, increased procollagen synthesis has been found within 2-4 days at the site of the wound (23-25), and serum PICP started to increase from day 4 (25) with a maximum increase occurring between days 10 and 21 (26,27). Serum PICP has been reported to be increased 3-5 days after PTX (18,19) which is consistent with the present study.…”

Section: Discussionsupporting

confidence: 81%

Immediate changes in biochemical markers of bone turnover and circulating interleukin-6 after parathyroidectomy for primary hyperparathyroidism

Guo

Holland²,

Jackson³

et al. 2000

European Journal of Endocrinology

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Objective: The time course of the immediate change in bone turnover after parathyroidectomy (PTX) for primary hyperparathyroidism (PHPT) is not clear. It is uncertain whether circulating interleukin-6 (IL-6) plays a role in mediating the acute withdrawal of the effects of parathyroid hormone (PTH) on bone turnover after PTX. The aims of this study were to determine the time course of immediate changes in biochemical markers of bone turnover after PTX and whether circulating IL-6 is involved in the immediate changes of bone turnover after PTX. Design and Methods: IL-6 and bone turnover markers were measured in eight women (aged 55 Ϯ 11 years, mean Ϯ S.D.) with PHTP at baseline and at 1-2 h, and 1, 2, 5, 7 and 12 days after PTX. We compared the results with those from eight individually matched women (healthy controls) and five subjects undergoing major surgery (surgical controls). Results: At baseline, serum levels of IL-6 and bone turnover markers were higher in PHPT than those in healthy controls (P<0.05). Serum levels of procollagen propeptides increased by 22 and 27% at days 2 and 5, respectively, compared with baseline (P < 0.05). Serum tartrate-resistant acid phosphatase decreased by 2 days after PTX, and urinary collagen crosslinks decreased significantly by 21-41% within 24 h (P<0.05). Serum IL-6 levels increased immediately in both PHPT and surgical controls at postoperative follow-up (repeated measures ANOVA). Conclusions: (1) PTX decreases bone resorption immediately and (2) circulating IL-6 is not involved in the changes in bone turnover immediately after PTX.

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Section: Discussionsupporting

confidence: 81%

Immediate changes in biochemical markers of bone turnover and circulating interleukin-6 after parathyroidectomy for primary hyperparathyroidism

Guo

Holland²,

Jackson³

et al. 2000

European Journal of Endocrinology

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“…11,12 in the surgical wounds or at the anastomosis site. It hampers the immune responses, such as macrophage activation and granuloma formation.…”

Section: Discussionmentioning

confidence: 99%

Clinical Study on Factors Influencing Wound Dehiscence in Emergency Exploratory Laparotomy

Talukdar¹,

Gopalarathnam²,

Paul³

et al. 2016

jemds

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BACKGROUNDWound dehiscence is a mental, financial and physical trauma to patients and has an equivalent effect on surgeon too. Wound dehiscence etches profound morbidity in a patient's life. There arises an expanding demand in the cost of care, both in terms of increased hospital stay and manpower in nursing and managing of burst wound and its complications. Thus understanding of factors contributing to dehiscence, correctable measures and precautionary steps are very much essential in day-to-day practice of all surgeons. This ignited our thoughts to conduct a study and understand wound healing and dehiscence in a better way.

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“…In order to clarify the time course of collagen synthesis with the present method, extensive measurements with a large number of patients are needed. The concentrations of PICP and PIIINP increase markedly in wound fluid after surgery but normalize within a few months (Haukipuro et al, 1992). Hence, the increased skin collagen synthesis can not be due to the healing of mastectomy wounds.…”

Section: Discussionmentioning

confidence: 97%

Demonstration of increased collagen synthesis in irradiated human skin in vivo

Autio

Saarto²,

Tenhunen³

et al. 1998

Br J Cancer

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Summary Fibrosis is a common side-effect of radiation therapy. As a complex network of cytokines and other mediators plays a central role in the process leading to fibrosis, we used an in vivo method to measure skin collagen synthesis, taking into account the physiological conditions. We determined suction blister (i.e. interstitial) fluid concentrations of types and IlIl procollagen propeptides, reflecting types I and Ill collagen synthesis, in irradiated and unirradiated skin of breast cancer patients 1-5 years after surgery and radiation therapy, hence using the patients as their own controls. The mean concentrations of the measured collagen markers were approximately two times higher in the irradiated skin than in the unirradiated contralateral breast skin. The difference slowly diminishes with time. These results indicate that abundant collagen synthesis in the irradiated skin continues several years after discontinuation of the radiation therapy, leading to fibrosis.The method outlined here offers a new in vivo perspective to study events leading to radiation fibrosis.

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Connective tissue response to major surgery and postoperative infection

Cited by 27 publications

References 24 publications

Immediate changes in biochemical markers of bone turnover and circulating interleukin-6 after parathyroidectomy for primary hyperparathyroidism

Immediate changes in biochemical markers of bone turnover and circulating interleukin-6 after parathyroidectomy for primary hyperparathyroidism

Clinical Study on Factors Influencing Wound Dehiscence in Emergency Exploratory Laparotomy

Demonstration of increased collagen synthesis in irradiated human skin in vivo

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