Die Ursachen des Icterus neonatorum

Anselmino, K. J.; Hoffmann, F.

doi:10.1007/bf02085143

Cited by 13 publications

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“…Already in 1930, A nselm ino and H offm a nn [1] found that the oxygen dis sociation curve of the fetus shows a shift to the left of about 6 mm Hg as compared to the mother's blood and they thought this important for the gen esis of transitory hyperbilirubinaemia.…”

Section: Discussionmentioning

confidence: 99%

Position of the Oxygen Dissociation Curve in Newborns with Transitory Hyperbilirubinaemia

Petrich¹,

Göbel²,

Blanke³

1974

Neonatology

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Section: Discussionmentioning

confidence: 99%

Position of the Oxygen Dissociation Curve in Newborns with Transitory Hyperbilirubinaemia

Petrich¹,

Göbel²,

Blanke³

1974

Neonatology

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“…Plasma of eclamptic patients acidified (pH 4 to 4.5) with acetic acid and passed through an ultrafilter was studied by Anselmino and Hoffmann (15)(16)(17) in anesthetized rabbits. They appeared able to demonstrate the presence of a substance in the blood of eclamptic patients and those suffering from toxemia of pregnancy that they considered identical with the pressor hormone of the posterior pituitary body.…”

Section: Pi~essor Substances From Body Fluidsmentioning

confidence: 99%

Pressor Substances From the Body Fluids of Man in Health and Disease

Page

1935

Journal of Experimental Medicine

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1. Extracts of human blood plasma, ascitic and cerebrospinal fluids have been shown to contain a substance or substances which have a prolonged and powerful pressor action when injected into test animals. 2. The chemical properties of the substance suggest those of an organic base. It is extracted with alcohol, soluble in water and acetone, extracted from water by chloroform, and probably is but slightly heat-stable. The plasma colloids seem to hold the substance in a bound state since it does not appear in the ultrafiltrate and is liberated on coagulation of the colloids by alcohol. Coagulation alone of the blood does not cause the substance to be formed. 3. Its action suggests that its pressor effect is brought about by mediation of the central nervous system. This inference was drawn from the following observations. (a) The functional intactness of the central nervous system is essential in order that pressor responses be obtained. Unanesthetized animals exhibit greater vascular responses than do anesthetized. (b) Pithing animals completely abolishes the response. Progressive ablation of the brain to the level of the hind brain does not alter the response, but below this level, injury abolishes the activity of the extract. (c) Some substance in the extract sensitizes the mechanism responsible for the carotid sinus reflex. (d) There is no parallelism between the response to peripherally acting drugs and pressor extracts. (e) Removal of the adrenal glands does not affect its character. 4. The rise in blood pressure appears to be due especially to constriction of the arteries in the splanchnic region. 5. Assay of the pressor extracts is made difficult because of the dependence of the vascular response on the functional state of the central nervous system. The carotid sinus reflex and stimulation with carbon dioxide-air mixtures have proved most useful means for the estimation of this functional state. It has been pointed out that the vascular responses to extract, stimulation of the carotid sinus, and inhalation of carbon dioxide-air vary greatly during the course of an experiment on anesthetized animals. This natural history of the vascular responses has been described. 6. No evidence has been produced by the method employed that the amount of this pressor substance is increased in the blood or spinal fluid of patients with hypertension of varied pathogenesis (nephritic hypertension, essential hypertension, malignant hypertension, eclampsia, and pituitary basophilism).

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“…Desde 1910 Hofbauer (13) encontró tal fenómeno, hecho . que fue •confirmado en 1931 por ~nselmino •y Ho.ffmann (14). La presencia de ocitocina, vasopresina y adiuretina en cantidad apreciable en la sangre de las enfermas toxémicas, hizo que dichos autores le atribuyeran a la neuro-hipófisis gran importancia en la patogenia de los trastornos gestósicos.…”

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Etiopatogenia de la toxemia gravídica

Palacino

1959

Rev. Colomb. Obstet. Ginecol.

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Al emprender el estudio de la etiopatogenia de la toxemia gravídica, el primer obstáculo se encuentra en la interpretación de la acepción de su nombre. Quien dice toxemia habla de substancia tóxica en la sangre; entonces creamos en la conciencia la idea de un elemento capaz de desencadenar el trastorno de un estado que debería transcurrir sencilla y fisiológicamente.¿Pero existe realmente una substancia tóxica responsable de tal disfunción? A la luz de los conocimientos presentes, tal concepto de la toxemia gravídica no deja de ser una entelequia. Es el concepto más simplista de la interpretación patogénica del más grave cuadro médico que pueda acompañar y ser la consecuencia del estado grávido de la mujer.

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Die Ursachen des Icterus neonatorum

Cited by 13 publications

References 0 publications

Position of the Oxygen Dissociation Curve in Newborns with Transitory Hyperbilirubinaemia

Position of the Oxygen Dissociation Curve in Newborns with Transitory Hyperbilirubinaemia

Pressor Substances From the Body Fluids of Man in Health and Disease

Etiopatogenia de la toxemia gravídica

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