Die unterschiedliche Ausdehnung der Übergangszone in der Karotisgabel

Janzen, Jan; Lanzer, Peter; Rothenberger-Janzen, K; Vuong, P. N.

doi:10.1024/0301-1526.30.2.101

Cited by 19 publications

(3 citation statements)

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“…It has been argued that the subclavian artery, branching from either the brachiocephalic trunk or the aorta itself, features a persistence of the anatomical characteristics of elastic arteries of the parent structures. Conversely, the carotid artery changes in structure at the bifurcation level from an elastic to a muscular vessel in the internal carotid artery, which downstream wholly lacks the external elastic lamina in the horizontal segment of its cavernous portion 16,17 . The elastic layers composing the vessel wall of elastic arteries have been claimed to be protective from the development of atherosclerosis, acting as potential ‘shields’ against the passage of macromolecules into the intima, promoting atherosclerosis 18–21 …”

Section: Discussionmentioning

confidence: 99%

“…Conversely, the carotid artery changes in structure at the bifurcation level from an elastic to a muscular vessel in the internal carotid artery, which downstream wholly lacks the external elastic lamina in the horizontal segment of its cavernous portion. 16,17 The elastic layers composing the vessel wall of elastic arteries have been claimed to be protective from the development of atherosclerosis, acting as potential 'shields' against the passage of macromolecules into the intima, promoting atherosclerosis. [18][19][20][21] Such a hypothesis is reinforced by our parallel histopathologic analysis, showing that subclavian and common carotid arteries share an elastic structure, with a thicker tunica media made of compact layers of elastic fibers, while internal and external carotid arteries have a thicker tunica intima.…”

Section: Segments (N)mentioning

confidence: 99%

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Extent and progression of atherosclerosis in carotid and subclavian arteries: the Carotid Artery Subclavian Artery study

Pescetelli

Zimarino²,

Basso

et al. 2021

Journal of Cardiovascular Medicine

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Aims To define the prevalence, progression, and the relationship between carotid and subclavian artery atherosclerosis and to identify factors associated with disease progression in a population of asymptomatic patients. Methods Among all consecutive patients without a history of cardiovascular disease admitted to our hospital for duplex ultrasound examinations of the supra-aortic arteries, from January to December 2012, we retrospectively identified 530 patients with two evaluations at least 3 years apart. Each artery was graded according to stenosis degree, as absent or less than 20%, 20–49%, 50–69%, 70–99% and total occlusion. Disease progression was defined for any class increase at any time interval. Patients were grouped according to the presence of a more than 20% stenosis of the supra-aortic district at baseline, as controls, without atherosclerosis: n = 111, 21%; isolated carotid artery disease: n = 390, 74%; concomitant subclavian artery-carotid artery disease: n = 29, 5%. There were no cases with isolated subclavian artery atherosclerosis. Results The mean time-lapse between the two evaluations was 3.1 ± 0.3 years; we documented disease progression in 32 patients (6%), all limited to the carotid artery (P = 0.009 vs. controls, with no differences between isolated carotid artery disease and concomitant carotid and subclavian artery disease). Hypertension was significantly (P < 0.001) associated with disease progression, regardless of the single or double district involvement. Conclusion The subclavian artery is far less prone to atherosclerosis than the carotid artery, and features lesser disease progression. Understanding factors for the different susceptibility to atherosclerosis in these two close arterial districts provides insight into local factors prompting vascular disease.

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Section: Discussionmentioning

confidence: 99%

Section: Segments (N)mentioning

confidence: 99%

Extent and progression of atherosclerosis in carotid and subclavian arteries: the Carotid Artery Subclavian Artery study

Pescetelli

Zimarino²,

Basso

et al. 2021

Journal of Cardiovascular Medicine

View full text Add to dashboard Cite

show abstract

“…The underlying arterial structure could have a potential influence. The LMCA, proximal ICA, proximal renal artery and external iliac artery involve a transitional zone between elastic and muscular artery types [11,12], which are prone to foam cell lesions and lipid cores. In addition, the underlying differences in hemodynamics such as non-uniform distribution and higher time-dependent wall shear rate in carotid compared with femoral arteries [13] might be etiologic [14].…”

Section: Discussionmentioning

confidence: 99%

Plaque characteristics and arterial remodeling in coronary and peripheral arterial systems

et al. 2012

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Background Few studies have examined plaque characteristics among multiple arterial beds in vivo. The purpose of this study was to compare the plaque morphology and arterial remodeling between coronary and peripheral arteries using gray-scale and radiofrequency intravascular ultrasound (IVUS) at clinical presentation. Methods and Results IVUS imaging was performed in 68 patients with coronary and 93 with peripheral artery lesions (29 carotid, 50 renal, and 14 iliac arteries). Plaques were classified as fibroatheroma (VH-FA) (further subclassified as thin-capped [VH-TCFA] and thick-capped [VH-ThCFA]), fibrocalcific plaque (VH-FC) and pathological intimal thickening (VH-PIT). Plaque rupture (13% of coronary, 7% of carotid, 6% of renal, and 7% of iliac arteries; P=NS) and VHTCFA (37% of coronary, 24% of carotid, 16% of renal, and 7% of iliac arteries; p=0.02) were observed in all arteries. Compared with coronary arteries, VH-FA was less frequently observed in renal (p<0.001) and iliac arteries (p<0.006). Lesions with positive remodeling demonstrated more characteristics of VH-FA in coronary (84% vs. 25%, p<0.001), carotid (72% vs. 20%, p=0.001), and renal arteries (42% vs. 4%, p=0.001) compared with those with intermediate/negative remodeling. There was positive relationship between RI and percent necrotic area in all four arteries. Conclusions Atherosclerotic plaque phenotypes were heterogeneous among four different arteries; renal and iliac arteries had more stable phenotypes compared with coronary artery. In contrast, the associations of remodeling pattern with plaque phenotype and composition were similar among the various arterial beds.

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Lower blood flow velocity, higher resistance index, and larger diameter of extracranial carotid arteries are associated with ischemic stroke independently of carotid atherosclerosis and cardiovascular risk factors

Bai

Chen

Chiu

et al. 2007

J of Clinical Ultrasound

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Die unterschiedliche Ausdehnung der Übergangszone in der Karotisgabel

Cited by 19 publications

References 0 publications

Extent and progression of atherosclerosis in carotid and subclavian arteries: the Carotid Artery Subclavian Artery study

Extent and progression of atherosclerosis in carotid and subclavian arteries: the Carotid Artery Subclavian Artery study

Plaque characteristics and arterial remodeling in coronary and peripheral arterial systems

Lower blood flow velocity, higher resistance index, and larger diameter of extracranial carotid arteries are associated with ischemic stroke independently of carotid atherosclerosis and cardiovascular risk factors

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