Lower blood flow velocity, higher resistance index, and larger diameter of extracranial carotid arteries are associated with ischemic stroke independently of carotid atherosclerosis and cardiovascular risk factors

Bai, Chyi Huey; Chen, Jiunn Rong; Chiu, Hou Chang; Pan, Wen Harn

doi:10.1002/jcu.20351

Cited by 68 publications

(75 citation statements)

References 32 publications

(41 reference statements)

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“…Aging, cerebrovascular risk factors, and stroke status are associated with larger cross-sectional areas and slower, more pulsatile blood velocity within the large arteries. 12,13 Such changes occurring in proximity to the ASL labeling plane may confound CBF quantification in these clinical cohorts. For instance, age is associated with a decreased signal-to-noise ratio, due, in part, to increased variance between individual control-tag difference images.…”

mentioning

confidence: 99%

Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity

Robertson

Matta

Basile

et al. 2017

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:The relationship between extracranial large-artery characteristics and arterial spin-labeling MR imaging may influence the quality of arterial spin-labeling-CBF images for older adults with and without vascular pathology. We hypothesized that extracranial arterial blood velocity can explain between-person differences in arterial spin-labeling data systematically across clinical populations.

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mentioning

confidence: 99%

Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity

Robertson

Matta

Basile

et al. 2017

AJNR Am J Neuroradiol

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“…Our previous casecontrol study showed that end-diastolic velocity (EDV), peak systolic velocity (PSV), and resistive index (RI) measured in carotid artery were associated with IS. 9 Among these, EDV, a potential marker of intracranial resistance, 9 was most significant. Nevertheless, EDV was not studied before.…”

mentioning

confidence: 99%

Common Carotid End-Diastolic Velocity and Intima-Media Thickness Jointly Predict Ischemic Stroke in Taiwan

Chuang

Bai

Chen

et al. 2011

Stroke

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Background and Purpose-In Asian populations, few studies investigated the association between stroke and common carotid artery intima-media thickness (IMT). Our previous case-control studies showed that low end-diastolic velocity (EDV) in common carotid artery, a potential hemodynamic marker of intracranial resistance, was associated with ischemic stroke. Therefore, we investigated the relationship between both EDV and IMT and incident ischemic stroke in an Asian population. Methods-Baseline data from 3175 adults (30 years or older) in the Cardiovascular Diseases Risk Factor Two-Township Study were linked to incidental ischemic stroke status derived from insurance claims and death certificate records.Hazard ratios for risk of ischemic stroke for high IMT and low EDV values measured in common carotid artery were calculated using Cox proportional hazard models.

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“…Therefore, improvement in diastolic velocity may protect the patient from ischemic stroke as it keeps adequate blood flow during diastole. Pulsatility index and resistive index may reflect the compliance of the vessel and therefore, high PI and/or RI may indicate increase vascular resistance and increase in arterial stiffness [15,16]. Previous studies showed that diabetic patients have higher resistive index than normal population and this may increase micro-and macro-vascular complications [32].…”

Section: Discussionmentioning

confidence: 99%

“…Increase in resistive index means decrease in compliance of artery and atherosclerosis [13]. Increase in pulsatility index means reduction in perfusion of cerebral tissue [14][15][16]. Metformin is the only member of the biguanide group of oral anti-diabetic drugs available for use today.…”

Section: Introductionmentioning

confidence: 99%

Effects of metformin on middle cerebral artery flow velocity in newly diagnosed type 2 Diabetic patients

2016

AJBM

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Type 2 diabetes mellitus is a major cause of cerebrovascular disease. Risk of ischemic stroke is higher in diabetic patients and it is about 2-6 times that in normal population. Atherosclerotic lesions happen early in the disease and patients with type 2 diabetes mellitus. Transcranial Doppler can be used for examination of cerebral arteries and it can detect early atherosclerotic changes. Metformin an old oral anti-diabetic drug but still cornerstone in the treatment guidelines of type 2 diabetes mellitus. It improves endothelial function with preferable cardiovascular effects. Twenty patients were recruited for the study. Transcranial Doppler examination done for all patients before initiation of treatment. Patients received metformin for twelve weeks and they were re-examined with transcranial Doppler. The data of present study showed that a highly significant increase in diastolic velocity and mean flow velocity after treatment with significant reduction in pulsatility index and resistive index. In conclusion, metformin treatment increases cerebral diastolic flow velocity with reduction in vascular resistance in patients with type 2 diabetes.

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Lower blood flow velocity, higher resistance index, and larger diameter of extracranial carotid arteries are associated with ischemic stroke independently of carotid atherosclerosis and cardiovascular risk factors

Cited by 68 publications

References 32 publications

Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity

Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity

Common Carotid End-Diastolic Velocity and Intima-Media Thickness Jointly Predict Ischemic Stroke in Taiwan

Effects of metformin on middle cerebral artery flow velocity in newly diagnosed type 2 Diabetic patients

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