Die Transplantation vitaler Langerhans’scher Inseln bei diabetischen Empfängertieren

Rumpf, K. D.; Schweitzer, G.; Pichlmayr, R.; Trautschold, I.

doi:10.1007/978-3-662-05557-1_21

Cited by 4 publications

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“…Durch Verpflanzung des gesamten Pankreasorgans [4,10,11] 2. Die Transplantation isolierter Langerhansscher Inseln wird seit einigen Jahren von verschiedenen Arbeitsgruppen tierexperimentell untersucht [3,5,7,14,15]. Die Transplantation isolierter Langerhansscher Inseln wird seit einigen Jahren von verschiedenen Arbeitsgruppen tierexperimentell untersucht [3,5,7,14,15].…”

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Methoden zur Funktionskontrolle transplantierter Langerhansscher Inseln

Rumpf

Zick

Thiele

1976

Langenbecks Arch Chiv

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The various groups who are working on islet-transplantation used different parameters in determining the success or failure of their experiments. In our own transplantation-trials we tested the value of using the symptoms typical of diabetic humans for rats. These are: change in bodyweight, water intake, urine-volume and glucose content as well as the glucose-level in the blood. Special diabetic provocation-tests were also carried out with rats. It was shown, that the i.v. glucose-tolerance-test (IVGTT) and the glucose assimilation-coefficient (GAC) were able to demonstrate the reversal of the diabetic state after islet-transplantation. The tolbutamid-test gave no additional evidence about the success of the transplantation. Histological examinations should always be carried out in addition to the biochemical tests, because a decrease in the islet's-function is shown to depend on a higher rate of morphological regressions.

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Methoden zur Funktionskontrolle transplantierter Langerhansscher Inseln

Rumpf

Zick

Thiele

1976

Langenbecks Arch Chiv

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Transplantation of isologous islets of langerhans in diabetic rats. Long-term immunohistochemical results

et al. 1977

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Isologous isolated islets of Langerhans were transplanted into the peritoneum and through the portal vein into the liver of diabetic rats. This resulted in the normalization of fasting blood glucose levels, with clear improvement of glucose tolerance tests. The results after intrahepatic implantation were better than after intraperitoneal implantation. Three months after implantation of islets into the peritoneum diabetes recurred and after one year only 2 of the 15 rats were alive, with high blood glucoe levels. In the group with intrahepatic islets the normalization of blood glucose was maintained over a period of one year. Immunohistochemical insulin proofs were positive in the peritoneum over a period of 3 months and in the liver up to one year after implantation. Glucagon proofs were positive in the intraperitoneal islets for 6 weeks and in intrahepatic ones for one year. Morphological examination of transplanted islets suggested that the liver is better suited for islet transplantation than the peritoneum.

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