Die Rindenprojektion der Thalamuskerne bei der Maus. Eine experimentell-anatomische Untersuchung

Grünthal, E.

doi:10.1159/000148358

Cited by 9 publications

(2 citation statements)

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“…Also on the basis of results obtained with an anterograde degeneration technique, Leonard [1969] questioned the existence of a mediodorsal frontopolar projection in the rat. Later re sults [Divac et al, 1978b;Krettek and Price, 1977] tended to include this area in the rat's prefrontal cortex, though Divac et al [1978] found with diaminobenzidine- For the mouse, Griinthal [1945] found no cortical projections of the mediodorsal nucleus, referred to by him as nucleus internus. His failure is, however, not surpris ing, as he used the retrograde degenera tion method, a method which Leonard [1969] described as inappropriate for trac ing the corresponding projections in the rat.…”

Section: Discussionmentioning

confidence: 96%

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Prefrontal Cortex of the Mouse Defined as Cortical Projection Area of the Thalamic Mediodorsal Nucleus

1981

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In the mouse small amounts of horseradish peroxidase were injected iontophoretically into different portions of the frontal lobe. Out of a large number of mice, 18 with typical injections which together covered most of the anterior half of the cortex were selected, and their retrogradely labeled thalamic cells were described and illustrated in detail. Special emphasis was laid on the cortical projections of the mediodorsal nucleus which were considered to define locus and extent of the prefrontal cortex. The results reveal that topographically the extent of the mouse's prefrontal cortex closely resembles that of the rat, another species of the rodent order. It includes a small area within and dorsal to the rhinal sulcus and a comparatively larger region within the medial half of the anterior cortex. Furthermore, the dorsal tip of the frontal pole is reached by a considerable number of afferents from the mediodorsal nucleus. Whether this last projection also exists in the rat is still disputed. As in the rat, only the sulcal prefrontal cortex seems to be reached by mediodorsal cells alone, whereas the rest of the prefrontal cortical fields have overlapping projections from the anteromedial nucleus. Though a considerable area within the frontal lobe of the mouse is reached by mediodorsal afferents, the significance and usefulness of this definition of the prefrontal cortex is questioned.

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Section: Discussionmentioning

confidence: 96%

“…Griinthal [1945] provided an early description of various thalamocorti cal projections. His proposed thalamic projections to the medial and frontal cor tex are, however, not in accordance with recent findings in the rat.…”

Section: Introductionmentioning

confidence: 99%

Prefrontal Cortex of the Mouse Defined as Cortical Projection Area of the Thalamic Mediodorsal Nucleus

1981

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Cortical and thalamic areas involved in taste discrimination in the albino rat

Benjamin

Akert

1959

J of Comparative Neurology

133

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Effects of early vibrissae damage on neurons in the ventrobasal (VB) thalamus of the mouse

Woolsey

Anderson

Wann

et al. 1979

J of Comparative Neurology

105

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We have examined the effects of vibrissal damage on the structure of the VB of the murine thalamus. The findings are: (1) The barreloid (Van der Loos, '76) pattern can be recognized in the normal adult mouse thalamus. On the basis of size, the population of VB neurons is bimodal, the larger neurons-presumed to be thalamocortical relay cells (TCR's) -outnumbering the smaller neurons-presumed to be thalamic interneurons-by 3: 1. (2) Damage to vibrissa Row-C on PND-1 (postnatal day-1) results in an altered cytoarchitectonic pattern in the barreloids in the contralateral VB, which is qualitatively similar to the altered pattern of barrels in the cortex. The middle row of large barreloids is affected, which is anatomical evidence for the pattern of somatotopic organization in mouse VB. (3) The time course of alterations in thalamic architecture is different than that for the barrels in the cortex. The barreloids show progressively less severe alteration with increasing age a t the time the peripheral lesions are made, like the barrels in the cortex. However, the thalamus of animals lesioned on PND-4 or later appears normal, while the cortex of animals lesioned on PND-4 and PND-5 still can be altered. Thus, in the thalamus, as in the cortex, there is a "critical period" during which vibrissal damage alters cytoarchitectonic patterns, but the thalamic "critical period" ends about two days before that in the cortex. (4) Measurements of TCR's in the barreloids did not reveal any statistically significant size differences between neurons in different sectors of the experimental thalami. In particular, we could find no evidence for increases of TCR size in barreloids bordering affected Row-C barreloid zones or for reductions in TCR size in barreloids in the C-zones. (5) In Timm's stained normal material there is a parallel development of Timm's positive staining in the thalamus and in the cortex. Barreloid related Timm's positive staining appears by PND-4, while Timm's staining in the cortical barrel hollows appears later by PND-8. Of particular interest is the difference in the appearance of the barrels with the Timm's stain in the PND-8 animals and in adults. In the former, the barrel hollows are filled with granular precipitate, while in the latter they are practically devoid of Timm's precipitate, suggesting a major changeover in the staining pattern (and possibly the functional attributes) of the terminal fields of the thalamocortical afferents in postnatal development.The neurons of layer IV of the mouse SmI middle row of vibrissae (row-C) which were face cortex are organized into multicellular made on different postnatal days (PND)) cytoarchitectonic units

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Die Rindenprojektion der Thalamuskerne bei der Maus. Eine experimentell-anatomische Untersuchung

Cited by 9 publications

References 0 publications

Prefrontal Cortex of the Mouse Defined as Cortical Projection Area of the Thalamic Mediodorsal Nucleus

Prefrontal Cortex of the Mouse Defined as Cortical Projection Area of the Thalamic Mediodorsal Nucleus

Cortical and thalamic areas involved in taste discrimination in the albino rat

Effects of early vibrissae damage on neurons in the ventrobasal (VB) thalamus of the mouse

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