Cortical and thalamic areas involved in taste discrimination in the albino rat

Benjamin, Robert M.; Akert, K.

doi:10.1002/cne.901110203

Cited by 133 publications

(55 citation statements)

References 17 publications

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“…Following these procedures, small electrolytic lesions were produced within VPM and tissue was subsequently analyzed with the silver-degeneration method of Nauta (1957). These results essentially corroborated the findings of Benjamin and Akert (1959), in that fiber degeneration was traced to the facial somatic region. In later experiments, Norgren and Wolf (1975) employed similar techniques, but included sapid stimulation of the tongue and the more sensitive argyrophilic reaction of Fink and Heimer (1967).…”

Section: Gustatory Neocortex 15supporting

confidence: 80%

“…For example, it was recognized by Bagshaw and Pribram (1953) that projections from thalamus to insula could be damaged via aspiration of deep cortical tissue of the superior temporal gyrus, and this factor could possibly complicate the localization of cortical gustatory function. As suggested by Benjamin and Akert (1959), the lissencephalic brain of the rat offered obvious advantages in terms of producing precise cortical lesions, or conducting surface cortical electrophysiology. The use of this species did, however, prevent detailed comparative analyses, since the insular cortical areas are not topically defined.…”

Section: Gustatory Neocortex 15mentioning

confidence: 99%

“…Ablation ofthe ventral portion of this composite region produced elevations in the rejection threshold to quinine drinking solutions. Finally, subsequent experiments (Benjamin & Akert, 1959) evaluated retrograde cellular degeneration within the diencephalon which was associated with quinine detection deficits. Although the conclusions afforded by degeneration analyses using the Nissl method were tentative at the time (Benjamin & Akert, 1959), these authors concluded that degeneration of a limited population of neurons within posterior ventromedial thalamus were best correlated with quinine detection deficits.…”

Section: Gustatory Neocortex 15mentioning

confidence: 99%

“…Finally, subsequent experiments (Benjamin & Akert, 1959) evaluated retrograde cellular degeneration within the diencephalon which was associated with quinine detection deficits. Although the conclusions afforded by degeneration analyses using the Nissl method were tentative at the time (Benjamin & Akert, 1959), these authors concluded that degeneration of a limited population of neurons within posterior ventromedial thalamus were best correlated with quinine detection deficits. Thus, the results obtained by Benjamin and his associates suggested that the gustatory cortical region in rat was located in or near regions previously implicated in monkey and cat.…”

Section: Gustatory Neocortex 15mentioning

confidence: 99%

“…Cortical Projections: Early Research While the research of Benjamin and his colleagues (e.g., Benjamin & Akert, 1959;Benjamin & Pfaffmann, 1955) presented the strongest case for localizing the cortical taste area within the somatic facial region, these efforts were guided by a substantial number of earlier investigations. Prior to the 1940s there was a tacit assumption that taste information was processed within areas of the parahippocampus and allocortex.…”

Section: Gustatory Neocortex 15mentioning

confidence: 99%

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The gustatory neocortex of the rat

1982

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Research findings related to the functional significance of the gustatory neocortical system of the rat are reviewed and interpreted. Studies of gustatory neocortex (GN) involvement in taste-related cognitive processes are emphasized after briefly reviewing GN anatomy and physiology. Evidence is presented supporting the conclusion that the GN contributes relatively little to fundamental taste reactivity, but is deeply involved in cognitive (learning and memorial) taste processes; that is, "reactive salience" to taste stimuli is preserved following GN ablation, while "associative salience" is markedly degraded. Apparent functional similarities between GN and other sensory neocortical areas are emphasized throughout the paper, and a hierarchical view of gustatory system functioning is addressed.Patton began his 1950 review of the chemical senses by pointing out that taste and smell essentially had been neglected relative to the other sensory systems. As a partial explanation for this neglect, he men-

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Section: Gustatory Neocortex 15supporting

confidence: 80%

Section: Gustatory Neocortex 15mentioning

confidence: 99%

Section: Gustatory Neocortex 15mentioning

confidence: 99%

Section: Gustatory Neocortex 15mentioning

confidence: 99%

Section: Gustatory Neocortex 15mentioning

confidence: 99%

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The gustatory neocortex of the rat

1982

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Human forebrain activation by visceral stimuli

et al. 1999

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Morphology and connectivity of parabrachial and cortical inputs to gustatory thalamus in rats

Holtz

Loflin

et al. 2014

J of Comparative Neurology

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Ventroposterior medialis parvocellularis (VPMpc) of thalamus, the thalamic relay nucleus for gustatory sensation, receives primary input from parabrachial nucleus, and projects to insular cortex. To reveal unique properties of gustatory thalamus in comparison to archetypical sensory relay nuclei, this study examines the morphology of synaptic circuitry in VPMpc, focusing on parabrachiothalamic driver input and corticothalamic feedback. Anterogradely visualized parabrachiothalamic fibers in VPMpc bear large swellings. At electron microscope resolution, parabrachiothalamic axons are myelinated and make large boutons, forming multiple asymmetric, adherent and perforated synapses onto large caliber dendrites and dendrite initial segments. Labeled boutons contain dense-core vesicles, and they resemble a population of calcitonin gene-related peptide containing terminals within VPMpc. As typical of primary inputs to other thalamic nuclei, parabrachiothalamic terminals are over 5 times larger than other inputs, while constituting only 2% of all synapses. Glomeruli and triadic arrangements, characteristic features of other sensory thalamic nuclei, are not encountered. As revealed by anterograde tracer injections into insular cortex, corticothalamic projections in VPMpc form a dense network of fine fibers bearing small boutons. Corticothalamic terminals within VPMpc were also observed to synapse on cells that were retrogradely filled from the same injections. The results constitute an initial survey in describing unique anatomical properties of rodent gustatory thalamus.

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Cortical and thalamic areas involved in taste discrimination in the albino rat

Cited by 133 publications

References 17 publications

The gustatory neocortex of the rat

The gustatory neocortex of the rat

Human forebrain activation by visceral stimuli

Morphology and connectivity of parabrachial and cortical inputs to gustatory thalamus in rats

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