Human forebrain activation by visceral stimuli

King, Andrew B.; Menon, Ravi S.; Hachinski, Vladimir; Cechetto, David F.

doi:10.1002/(sici)1096-9861(19991101)413:4<572::aid-cne6>3.0.co;2-s

Cited by 186 publications

(120 citation statements)

References 40 publications

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“…The first fMRI report to study reflex cardiovascular control in humans (King et al, 1999) outlined a large group of forebrain regions co-activated during brief maximal effort handgrip exercise. During these tasks increased cortical activation was observed in the hand regions of the contralateral motor and sensory cortices, medial prefrontal cortex (MPFC), ACC, bilateral IC, thalamus, amygdala and regions of the cerebellum.…”

Section: Section 1: Overviewmentioning

confidence: 99%

Forebrain organization for autonomic cardiovascular control

Shoemaker

Norton

Baker

et al. 2015

Autonomic Neuroscience

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Section: Section 1: Overviewmentioning

confidence: 99%

Forebrain organization for autonomic cardiovascular control

Shoemaker

Norton

Baker

et al. 2015

Autonomic Neuroscience

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“…Desgleichen scheinen nicht nur viszerale Schmerzempfindungen, sondern auch andere viszerale Empfindungen (z. B. Geschmacksempfindungen), viszerale Ereignisse, die mit dem kardiovaskulären System, der Lunge oder dem MagenDarm-Trakt assoziiert sind, und sensorische Ereignisse, die mit dem tiefen somatischen Bereich (Skelettmuskulatur) assoziiert sind, im Inselkortex repräsen-tiert zu sein [6,7,12,67,116]. Das Areal im Inselkortex, welches Nozizeption und Thermorezeption repräsentiert, ist einem Areal der Insel benachbart, welches (über das dem VMpo benachbarte thalamische Kerngebiet VMb) Informationen von vagalen Afferenzen und gustatoriKerngebiet der Striae terminales und auch direkt zum Inselkortex [18, 101a].…”

Section: Abb7a-c Stumme Mechanoinsensible Unmyelinisierte Afferenz unclassified

Physiologie und Pathophysiologie viszeraler Schmerzen

Jänig¹,

Häbler

2002

Der Schmerz

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Visceral pain is diffusely localized, referred to deep somatic tissues, skin and viscera, frequently not correlated with an actual trauma, commonly correlated with strong negative affective reactions and accompanied by strong protective autonomic and motor reactions. It is correlated with the excitation of spinal (thoraco-lumbar, sacral) visceral afferents and (with a few exceptions) not with the excitation of vagal afferents. Spinal visceral afferents are polymodal and can be excited by physical and chemical stimuli. All groups of visceral afferents can be sensitized (e.g.by inflammation). Normally silent (mechanically insensitive) visceral afferents are recruited by inflammation. Individual visceral afferent neurons project in laminae I and V of the dorsal horn over several segments, medio-lateral over the entire width of the dorsal horn and to the contralateral side. Their activity is synaptically transmitted, in these and deeper laminae, to viscero-somatic convergent neurons which receive additional afferent synaptic input from skin and deep somatic tissues of the corresponding dermatomes,myotomes and sclerotomes. The mechanism of sensitization of viscerosomatic convergent neurons (central sensitization) during sensitization of spinal visceral afferents is unclear.Viscero-somatic tract neurons project to lower and upper brain stem,hypothalamus and via the thalamus to various cortex areas. Visceral nociception and pain is presumably (together with other visceral sensations and homeostatic regulations of autonomic body functions) primarily represented in the insula in the context of interoception. The insula obtains its main peripheral afferent input from lamina I neurons via the Nucleus ventromedialis posterior of the thalamus. The transmission of visceral impulses in the spinal cord is modulated by the endogenous control systems in the brain stem which are in turn under the control of cortex and limbic system.

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“…These structures are known to be involved both in emotion processing and cardiovascular control which could explain the hypothesized link between cardiovascular reactivity and interoceptive awareness during emotion processing. The cingulate gyrus subserves visceromotor control (Vogt et al, 1992) and is strongly involved in the processing of cardiovascular signals (Allman and Rice, 2001;Benarroch, 1993;Cameron, 2001;Critchley et al, 2000Critchley et al, , 2001Devinsky et al, 1995;King et al, 1999;Williamson et al, 1999Williamson et al, , 2002. Additionally, it supports the regulation of many cognitive and emotional processes (Lane et al, 1997;Phan et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, it supports the regulation of many cognitive and emotional processes (Lane et al, 1997;Phan et al, 2002). The insula, especially the right insula, is an essential structure for the processing of cardiovascular signals (Augustine, 1996;Benarroch, 1993;Cameron, 2001Cameron, , 2002Yasui et al, 1991) and is commonly activated by cardiovascular arousal (Critchley et al, 2000(Critchley et al, , 2001King et al, 1999;Williamson et al, 1999Williamson et al, , 2002. Furthermore, the insula is activated during the evaluation and the processing of emotions (Critchley et al, 2004;Damasio et al, 2000;Phan et al, 2002).…”

Section: Introductionmentioning

confidence: 99%