Die Resorption von Wasser aus Kochsalz- und Zuckerlösungen

McDougall, Edward; Verzár, F.

doi:10.1007/bf01752346

Cited by 16 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…McDongaU and Verzar (19) concluded that water movements from isotonic solutions could be explained entirely by the movements of solutes, and Wells (20) found that the rate of water absorption from the intestine was linearly related to the hydrostatic pressure of the solution in the lumen. Goldschmidt and Dayton (1) on the basis of their studies of water movement in dog intestine, consequent to changes in the tonicity of the plasma and of the fluid in the intestinal lumen, have concluded that at least a part of the water movement must be due to passive processes.…”

Section: Discussionmentioning

confidence: 99%

“…(3) and Wells (20) have found water movement in response to osmotic and hydrostatic gradients respectively. In the rat, McDougall and Verzar (19) have observed that water movement follows the osmotic gradient when anisotonic solutions were placed in the lumen of anesthetized animals. This is in agreement with the results of the present studies, as shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

“…ScarM., 1949,19,43). The electrical potential difference between the lumen and plasma has been interpreted as a diffusion potential slightly modified by the excess of active C1 flux over active Na flux.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Ion and Water Fluxes in the Ileum of Rats

Curran

Solomon

1957

The Journal of General Physiology

276

View full text Add to dashboard Cite

Studies have been carried out on the movement of salt and water across the small intestine of the rat. Segments of the ileum of anesthetized rats have been perfused i~ v/vo with unbuffered NaC1 solutions or isotonic solutions of NaC1 and mannitol. Kinetic analysis of movements of Na ~ and CP s has permitted determination of the eCflux and influx of Na and C1. Net water absorption has been measured using hemoglobin as a reference substance.water was found to move freely in response to gradients of osmotic pressure. Net water flux from isotonic solutions with varying NaC1 concentration was directly dependent on net solute flux. The amount of water absorbed was equivalent to the amount required to maintain the absorbed solute at isotonic concentration. These results have been interpreted as indicating that water movement is a passive process depending on gradients of water activity and on the rate of absorption of solute.The effiuxes of Na and Cl are linear functions of concentration in the lumen, but both ions are actively transported by the ileum according to the criterion of Ussing (Acta Physiol. ScarM., 1949, 19, 43). The electrical potential difference between the lumen and plasma has been interpreted as a diffusion potential slightly modified by the excess of active C1 flux over active Na flux.The physical properties of the epithelial membrane indicate that it is equivalent to a membrane having negatively charged uniform right circular pores of 36/~ radius occupying 0.001 per cent of the surface area. I t has long been recognized that the intestinal epithelium is permeable in both directions to dissolved substances and to water. Goldschmidt and Dayton (1) showed that NaC1 entered the colon of dogs from the blOod, and a number of investigators have observed that water moves relatively freely, since it is absorbed rapidly from hypotonic solutions placed in the intestine but enters hypertonic solutions. Visscher et al. (2,3) using radioactive Na and C1 and D~O as tracers confirmed and extended these earlier results. More recently, absorption of NaC1 and water has been studied

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%