Die Pathologie der Uterusmyome

Bolck, F.

doi:10.1007/978-3-642-53811-7_19

Cited by 1 publication

(2 citation statements)

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“…Laitinen (1964) reported that hyperplasia was the most common change in the endometrium belonging to a myomatous uterus, but endometrial oedema may be confused with hyperplasia. Bolck (1961) described hyperplastic, normal, and atrophic areas in the endometrium of myomatous uteruses and an irregular excretion of oestrogens in these patients. Rechnitz and Domotori (1964) examined 1,255 cases of myomatous uterus.…”

Section: Discussionmentioning

confidence: 88%

“…In 1935, Witherspoon described three pathological changes, aetiologically closely related: (1) myoma of uterus, (2) microcystic degeneration of the ovary with incomplete luteinization, and (3) cystic glandular hyperplasia of the endometrium. According to Bolck (1961), different authors reported that the association between uterine myoma and endometrial hyperplasia varied between 6 % and 80 %. Granjon, Yanotti, and Cedard (1961) found high oestrogen levels in women with uterine fibroids and believed that the endometrium played a role in the synthesis of oestrogens.…”

Section: Discussionmentioning

confidence: 99%

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Endometrial changes associated with myomata of the uterus

Deligdish¹,

Loewenthal²

1970

J Clin Pathol

156

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SYNOPSISThe endometrium of 30 uteruses with myomata was studied at four standard sites. Glandular atrophy over a myoma or opposite a myoma was the most constant finding. At the margin of a myoma hyperplastic glands were frequently found, and distorted, elongated, or dilated glands were present at this site in half of all specimens. Other changes included adenomyosis and the separation of glands by muscle fibres from the basal layer of the endometrium. The coexistence of many of these findings in endometrial curettings can lead to the histological diagnosis of uterine myomata. Two factors, mechanical and hormonal, may be responsible and their mechanisms are discussed.The pathological changes of the endometrium that occur in the presence of uterine leiomyomata ('fibroids') have been studied with special reference to submucous myomata. The recognition of similar changes in endometrial curettings can enable the presence of myomata to be suspected. It has been possible to show that some of the endometrial changes are due to the mechanical presence of a myoma, whilst other abnormalities appear to be the result of hormonal disturbances. Material and MethodsThirty uteruses with myomata, removed by total or subtotal hysterectomy, were examined. The patients' ages ranged between 31 and 54, with an average age of 45 years. Twenty specimens contained multiple submucous, intramural, and subserous myomata; in the remaining 10 there was a single submucous myoma. The changes in the endometrium were recorded in the following four constant areas of each uterus ( Fig. 1): (1) the endometrium overlying a submucous myoma; (2) the endometrium opposite a myoma; (3) the endometrium at the margin of a submucous myoma; (4) the endometrium from the Fig.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%