Die Pankreatrope Substanz aus dem Hypophysenvorderlappen

The ‘pancreotropic’ action of anterior pituitary extracts

“…(Received 2 October 1937) ANSELMINO, HEROLD & HOFFMANN [1933] have claimed that injections of a crude anterior pituitary extract into young, intact rats produce, in a few days, a marked increase in the number and size of the islets of Langerhans of the pancreas. They ascribed this increase to the action of a "pankreatrope Substanz", believed to be present in the pituitary gland.…”

“…The pancreotropic substance was found to be ultrafilterable, as it would pass through a collodion membrane at pH 5*2 . Although these authors have published further investigations on this subject [Anselmino et al 1935;Anselmino & Hoffmann, 1936b], their original claim lacks satisfactory confirmation, and in some instances negative results have been recorded [Leyton & Jones, 1936;Elmer et al 1937]. Chrzanowski & Grzycki [1937] are, so far as we are aware, the only authors claiming to have confirmed the belief of Anselmino & Hoffmann [1933] that a pH 5-2 ultra-filtrate of an aqueous extract of acetone dried pituitary gland can stimulate formation of islet tissue.…”