Abstract:Tramadol, a mixed mu-opioid agonist and a monoamine-reuptake blocking analgesic, has been supposed to have little effect on propulsive gastrointestinal motility. However, this has not been specifically studied in man. Following institutional approval, 18 human volunteers were given 50 mg of tramadol, tilidine/naloxone, and codeine, respectively, in a double-blind randomised cross-over design. Additionally, 12 further volunteers were given 100 mg of each opioid in a double-blind, randomised fashion, followed by… Show more
“…Es besteht auf Grund einer geringen Zahl von Publikationen nur eine schwache Evidenz für die Anwendung von Naloxon bei den Opioiden Tilidin, Tramadol, Codein und Morphin 434 435 436 437 438 439 440 441 .…”
Section: Therapie Der Opioid-induzierten Obstipation (Oic)unclassified
“…Es besteht auf Grund einer geringen Zahl von Publikationen nur eine schwache Evidenz für die Anwendung von Naloxon bei den Opioiden Tilidin, Tramadol, Codein und Morphin 434 435 436 437 438 439 440 441 .…”
Section: Therapie Der Opioid-induzierten Obstipation (Oic)unclassified
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