Die lactatdehydrogenase des innenohres

Lotz, Peter; Kühl, Kristian

doi:10.1007/bf00404159

Cited by 18 publications

(3 citation statements)

References 33 publications

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“…These findings are in marked contrast to the decrease in perilymph total protein content reported by Komarovich and Plouzhnikov (27) as occurring 30 min after intense stimulation followed by an increase 4 hr later and to the diminution in protein level 3 days after administration of ultrasound according to Lawler et al (28). Again, the parameters utilized in the current investigation might not have been adequate to incur a measurable change, especially, allowance of a longer time interval after stimulation for an effect.…”

Section: Discussioncontrasting

confidence: 99%

“…LDHi is more prominent in tissues where aerobiasis occurs whereas LDH5 figures notably in those undergoing glycolysis. In this and other studies (3)(4)(5)(6)32), patterns for perilymph showed the presence of high LDHi levels, thereby implicating aerobic pathways as a significant source of metabolic energy. The tricarboxylic acid cycle as an important pathway for the fluid is also suggested from the findings of Silverstein (2).…”

Section: Discussionsupporting

confidence: 70%

“…However, little work has been carried out on August 1974 various enzyme levels, the published accounts relating almost exclusively to ambient conditions. The enzymes screened have included phosphohexose isomerase (PHI), total lactic dehydrogenase (LDH), and the component isozymes and malic dehydrogenase (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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Biochemical Parameters of Guinea Pig Perilymph Sampled According to Scala and Following Sound Presentation

Gershbein¹,

Manshio²,

Shurrager³

1974

Environ Health Perspect

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Guinea pigs were exposed to sound varying from 2 to 8 kHz in frequency and 80-100 dB (SPL) in intensity for periods of 1 hr. The biochemical parameters, glucose, sodium, total protein, and the glycolytic enzymes, aldolase, phosphohexose isomerase, and total LDH as well as isozymes of the latter were ascertained for blood serum, perilymph, and, in some instances, cerebrospinal fluid. The three enzymes occurred at lower levels in perilymph as compared to blood serum. Except for a small difference in serum total protein, sound presentation incurred no significant effect on any of the above parameters. Definite differences in several metabolites were discerned for perilymph sampled according to scala and which were independent of the respective acoustical treatments. Thus, as compared to the scale tympani, the scala vestibuli perilymph displayed a higher glucose content and a diminished total LDH level and of the latter isozymes, LDHi ranged lower and LDH2, higher. As further evidence pointing to cerebrospinal fluid as the possible origin of perilymph, similarities in glucose contents and LDH isozyme patterns were noted for both fluids.

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Section: Discussioncontrasting

confidence: 99%