Die Insuffizienz der Ovarien bei Müttern von Mongoloiden

Geyer, Horst

doi:10.1007/bf02871641

Cited by 6 publications

(3 citation statements)

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“…Irregular menstruation, impaired generative faculty, recurrent abortions, and an increase in stillbirths and birth of children with congenital aberrations have been noted in mothers of patients with Down's syndrome (van der Scheer 1927, Geyer 1941, Benda 1949, @ster 1953, Lande-Champain 1954. However, more recent investigations with statistically comparable control groups often showed only slight differences or none at all , Ingalls et al 1957, Lunn 1959, Buck et al 196.5, Sigler 1967, Cowie & Slater 1968, Marmol et al 1969.…”

Section: A D Bmentioning

confidence: 99%

Month of birth and gametopathy

Jongbloet

1971

Clinical Genetics

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Monthly variations in the incidence of births of 441 patients with Down's syndrome, 317 patients with Klinefelter's syndrome, and 126 patients with Turner's syndrome were studied. These three chromosomal aberrations showed almost identical seasonal variation with two maxima, a greater maximum in the period February to May and a smaller one in September. These fluctuations synchronous with those of the “normal” birth curve, but have a greater amplitude. To explain the variations, the following hypothesis is proposed: Seasonal fluctuations in the “normal” conception curve are caused by two basic oestric patterns, of which a phylogenetically younger (polyoestrus) is superimposed upon the phylogenetically older one (mono‐ or dioestrus). The latter is influenced by climatologic factors. The seasonal fluctuations in the “normal” conception curve can be explained by alternating periods of normal, i.e. ovulatory, and of disturbed, i.e. anovulatory, cycles. The increase of “pathological conceptions” during spring and autumn and the crease during winter and summer are caused by interference of the two basic oestric patterns. Such interference might retard the preovulatory or intrafollicular ripening of the egg cell, resulting in overripeness ovopathy. In addition, spermatopathy, too, could be influenced by climatalogic factors. Birth curves of parents of patients with Down's syndrome may suggest a constitutional factor, predisposing to “pathologic conceptions”.

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Section: A D Bmentioning

confidence: 99%

Month of birth and gametopathy

Jongbloet

1971

Clinical Genetics

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“…Old fashioned terms such as "vitium primae formationis" [14], "dysplasmatic ovum" [11] and "borderline ovum" [24] have been introduced as causes of Down syndrome (DS) and/ or other congenital developmental defects. These are just * This paper was read at the Symposium on Pre-Conception Advice of the Nat.…”

Section: Introductionmentioning

confidence: 99%

The ageing gamete in relation to birth control failures and Down syndrome

1985

Eur J Pediatr

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Some indirect relationships between contraception failures and offspring with a pathological condition are reviewed, and a causal connection between them is suggested. This hypothesis is supported by the decreasing incidence of Down syndrome (DS) in general in recent years, and the increase among the younger maternal age categories as well as the effect of birth order. A more than doubled incidence of DS children among young Catholic mothers and the fact that conceptions of children with DS are preceded by unusually long periods of abstinence are emphasised and discussed. These data offer circumstantial evidence that the conceptions that occur despite application of the so called "natural" family planning methods in particular are at high risk. The impact of reproductive biological failures ("nature") and of reproductive behaviour ("nurture") on the human gametes can be disentangled by thorough studies of the epidemiology of major and minor congenital anomalies.

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“…a "vitium primae formationis". Geyer (22) spoke of a "dysplasmatic ovum" and Lande-Champain (40) of a "borderline ovum" as the cause of mongolism. Modern concepts of preovulatory and postovulatory overripeness ovopathy are no longer restricted to chromosomal aberrations, but also include a broad range of developmental anomalies, with or without normal karyotypes.…”

Section: Introductionmentioning

confidence: 99%

Preovulatory Overripeness of the Egg in the Human Subject

Jongbloet

Zwets

1976

Intl J Gynecology & Obste

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Anomalies of conception which endanger the ensuing pregnancy have been reviewed. The range of possible consequences include “occult” and early spontaneous abortions, a wide spectrum of chromosome defects, developmental anomalies, such as those of the brain (with a wide range of neuro‐psychopathology as a consequence) and possibly some other abnormalities of gestation. Pathology either of the pregnancy or of the products of conceptions caused by preovulatory overripeness ovopathy may be expected from conceptions that occur at times of changing endocrine patterns, reflected clinically in a transition from anovulation and vice versa. One can anticipate finding this conceptopathology reflected epidemiologically in a U‐shaped curve in relation to the reproductive age of the mother, in another U‐shaped curve relevant to the duration of the conception interval, and finally in a 4‐peaked birth curve related to seasonal variations of the ovulatory patterns.

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Die Insuffizienz der Ovarien bei Müttern von Mongoloiden

Cited by 6 publications

References 1 publication

Month of birth and gametopathy

Month of birth and gametopathy

The ageing gamete in relation to birth control failures and Down syndrome

Preovulatory Overripeness of the Egg in the Human Subject

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