“…The fibrillar structures may possibly be afflicted in other bullous conditions. In experimental blisters produced by proteolytic enzymes [3,4,9] or various salts [2,9,10], the dermo-epidermal separation occurs by a break-down of the anchoring filaments and the substance between the anchoring filaments and the half-desmosomes of the anchoring system. The fragility of the elastic fibrils in bullous pemphigoid might be due to the effects of some enzymic action.…”