Die Erbfaktoren der Haushühner

Hertwig, Paula; Rittershaus, Tine

doi:10.1007/bf01847140

Cited by 9 publications

(3 citation statements)

References 10 publications

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“…One of the loci responsible for feather development in chickens was described by Serebrovsky in 1922 [ 1 ] and is designated by the symbol K, standing for 'kürzer flügel' (short wing) [ 2 ]. The K allele is associated with the late feathering phenotype (LF) that causes a retard in the emergence of primary and secondary flight feathers.…”

Section: Introductionmentioning

confidence: 99%

Partial duplication of the PRLR and SPEF2 genes at the late feathering locus in chicken

et al. 2008

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Background: One of the loci responsible for feather development in chickens is K. The K allele is partially dominant to the k+ allele and causes a retard in the emergence of flight feathers at hatch. The K locus is sex linked and located on the Z chromosome. Therefore, the locus can be utilized to produce phenotypes that identify the sexes of chicks at hatch. Previous studies on the organization of the K allele concluded the integration of endogenous retrovirus 21 (ev21) into one of two large homologous segments located on the Z chromosome of late feathering chickens. In this study, a detailed molecular analysis of the K locus and a DNA test to distinguish between homozygous and heterozygous late feathering males are presented.

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Section: Introductionmentioning

confidence: 99%

Partial duplication of the PRLR and SPEF2 genes at the late feathering locus in chicken

et al. 2008

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“…The K locus, short for "short wing" (kürzer Flügel), is a region of chrZ with an early feathering (EF) allele and a late feathering (LF) allele [45,46]. The EF allele contains single copies of the genes 13 PRLR and SPEF2.…”

Section: Disentangling a Tandem Repeat And Viral Insertion At The K L...mentioning

confidence: 99%

A pangenome graph reference of 30 chicken genomes allows genotyping of large and complex structural variants

Rice¹,

Alberdi²,

Alfieri³

et al. 2023

Preprint

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Background. The red junglefowl, the wild progenitor of domestic chickens, has historically served as a reference for genomic studies of domestic chickens. These studies have provided insight into the etiology of traits of commercial importance. However, the use of a single reference genome does not capture diversity present among modern breeds, many of which have accumulated molecular changes due to drift and selection. While reference-based resequencing is well-suited to cataloging simple variants such as single nucleotide changes and short insertions and deletions, it is mostly inadequate to discover more complex structural variation in the genome. Results. We present a pangenome for the domestic chicken consisting of thirty assemblies of chickens from different breeds and research lines. We demonstrate how this pangenome can be used to catalog structural variants present in modern breeds and untangle complex nested variation. We show that alignment of short reads from 100 diverse wild and domestic chickens to this pangenome reduces reference bias by 38%, which affects downstream genotyping results. This approach also allows for the accurate genotyping of a large and complex pair of structural variants at the K ‘feathering’ locus using short reads, which would not be possible using a linear reference. Conclusions. We expect that this new paradigm of genomic reference will allow better pinpointing of exact mutations responsible for specific phenotypes, which will in turn be necessary for breeding chickens that meet new sustainability criteria and are resilient to quickly evolving pathogen threats.

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“…The distinction between EF and LF is based on the length of the primary feathers and primary-convert feathers at hatching, with primary feathers more than 2 mm longer than primary-convert feathers being EF, otherwise, they are considered as LF [ 3 ]. K allele is incompletely dominant to k + and has a retard effect on the primary and secondary flight feathers growth [ 4 , 5 , 6 , 7 ]. When homozygous EF males ( k + /k + ) mate with LF ( K/− ) females, their progeny males are LF ( K/k + ), and females are EF ( k + /− ), thus achieving gender separation.…”

Section: Introductionmentioning

confidence: 99%

Identification of Duplication Genotypes of the Feathering Rate Gene in Chicken by a Multiplex PCR Following Electrophoresis and/or Sanger Sequencing

Shen

Bao

et al. 2023

Animals

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Sex-linked phenotypes of late feathering (LF) and early feathering (EF) are controlled by a pair of alleles K and k+. Autosexing based on the feathering rate is widely used in poultry production. It is reported that a tandem duplication of 176,324 base pairs linked to the K locus is responsible for LF expression and could be used as a molecular marker to detect LF chicken. So far, there is no genotyping method that can accurately and stably identify the LF homozygote and heterozygote in all chicken breeds. In the present study, a multiplex PCR test was developed to identify EF, LF homozygote, and heterozygote according to electrophoretic bands and the relative height of the peaks by Sanger sequencing. We tested 413 chickens of six native Chinese breeds with this method. The identification was consistent with the sex and phenotype records of the chickens. Band density analysis was performed, and the results supported our genotyping using the new assay. In order to further verify the accuracy of this test in distinguishing homozygote and heterozygote males, 152 LF males were mated with EF females, and the results of the offspring’s phenotypes were consistent with our expectations. Our results support tandem duplication as molecular markers of LF, and this new test is applicable to all LF chickens associated with tandem duplication.

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Die Erbfaktoren der Haushühner

Cited by 9 publications

References 10 publications

Partial duplication of the PRLR and SPEF2 genes at the late feathering locus in chicken

Partial duplication of the PRLR and SPEF2 genes at the late feathering locus in chicken

A pangenome graph reference of 30 chicken genomes allows genotyping of large and complex structural variants

Identification of Duplication Genotypes of the Feathering Rate Gene in Chicken by a Multiplex PCR Following Electrophoresis and/or Sanger Sequencing

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