Die Entstehung der syphilitischen Blutveränderung und die Eigenschaften eines Spirochätenimmunserums

Klopstock, Felix

doi:10.1055/s-0028-1127630

Cited by 11 publications

(2 citation statements)

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“…For three serologically different types of Spironema pallidum (the Reiter-Kasan, the Kroo and the Noguchi type) corresponding antibodies were found in patients' serum. This would suggest that the state of "pan-immunity" which according to Kolle (1926) exists in a syphilitic individual is also reflected in his serum reactions.…”

Section: A Beck 307mentioning

confidence: 99%

“…NATURE OF THE SPIROCHAETAL ANTIGEN Because alcoholic extracts of spirochaetes had been used with good results as antigens in the complement-fixation reaction with syphilitic sera (Klopstock, 1926;Hoeltzer & Popoff, 1928), it was thought that they might contain the specific substance reacting with the spirochaetal antibody. For the examination of this question syphilitic sera were absorbed with such extracts, with carbolized suspensions of whole spirochaetes and with the WR antigen, and then tested with all these antigens.…”

Section: Agglutination Reactions With Culture Spirochaetesmentioning

confidence: 99%

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The role of the spirochaete in the Wassermann reaction

Beck¹

1939

J. Hyg.

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1. The examination of 1100 sera by both the Wassermann reaction and the complement-fixation test with spirochaetes revealed a superior sensitivity of the latter reaction and practically equal specificity of the two tests.2. Syphilitic serum contains two different antibodies: one reacting with the lipoid antigen of the Wassermann reaction, the other with a specific antigen in the spirochaete.3. The spirochaetal antibody of syphilitic serum has a complex serological structure, corresponding to spirochaete strains of different antigenic make-up.4. The existence of this antibody and its specific absorption by the homologous antigen can also be demonstrated by agglutination.5. The difference between agglutinin titres found in normal and syphilitic sera is not pronounced enough to render this method satisfactory for the practical diagnosis of syphilis.6. The spirochaete contains, apart from its specific antigen, the ubiquitous lipoid substance representing the Wassermann antigen.7. A fraction was obtained from spirochaetes by Raistrick and Topley's method which in complement-fixation and precipitation tests reacted actively with spirochaete antisera from rabbits, but which so far failed to react with syphilitic sera.This work was carried out with the aid of a grant from the Rockefeller Foundation. I wish to thank Prof. Golla, Director of the Central Pathological Laboratory, L.C.C. Mental Hospitals, who rendered this work possible, and Dr Arthur Davies, Director of the Devonport Laboratory, for the hospitality afforded me at his laboratory and for the patients’ sera used in this work. I am indebted to Prof. R. T. Hewlett for his revision of the manuscript, to Prof. Raistrick for advice in chemical matters, and to Dr Amies, of the Lister Institute, for his help with the Sharples centrifuge.

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Section: A Beck 307mentioning

confidence: 99%

Section: Agglutination Reactions With Culture Spirochaetesmentioning

confidence: 99%