Die Beeinflussung der Knochenheilung durch hochkonzentriertes Fibrin

Bösch, Peter; Braun, Felix; Eschberger, J; Kovac, W; Spängler, H.

doi:10.1007/bf00416954

Cited by 51 publications

(8 citation statements)

References 6 publications

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“…These quantitative data are in contrast to previous reports of improved bone formation and accelerated vascularization as a results of FS-treatment (Bosch et al 1977, 1979, 1980, Arbes et al 1981.…”

Section: Discussioncontrasting

confidence: 99%

“…Correspondence: Ulf Lucht, Mirabellevej 7, Denmark In bone transplantation, fibrin sealant (FS) has been reported to improve a homogeneous incorporation of the implant due to an accelerated vascularization (Bosch et al 1977, 1979, 1980, Arbes et al 1981, Bosch 1981. Special indications for adding FS to the graft have been claimed to be poor osteogenic potency of the recipient site, chronic osteomyelitis and implantation of an allograft (Bosch 1981).…”

Section: No Effects On Blood Flow and Bone Formation In Dogsmentioning

confidence: 99%

See 1 more Smart Citation

Fibrin sealant in bone transplantation: No effects on blood flow and bone formation in dogs

Lucht¹,

Bünger²,

Moller³

et al. 1986

Acta Orthopaedica Scandinavica

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Section: Discussioncontrasting

confidence: 99%

Section: No Effects On Blood Flow and Bone Formation In Dogsmentioning

confidence: 99%

Fibrin sealant in bone transplantation: No effects on blood flow and bone formation in dogs

Lucht¹,

Bünger²,

Moller³

et al. 1986

Acta Orthopaedica Scandinavica

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“…143 Similarly, Bösch et al found that while heterologous fibrin impaired the bone healing process, due to a local immune response, homologous fibrin accelerated the growth of capillary vessels and connective tissue cells, which resulted in rapid new bone formation. 144 Other researchers argued that the addition of a fibrin sealant to coral granules limited the infiltration of osteoprogenitor cells into the implantation area. 145 This was further confirmed by an observed delay in bone formation in femoral defects of rats implanted with fibrin-containing PLGA/calcium phosphate scaffolds.…”

mentioning

confidence: 99%

A review of fibrin and fibrin composites for bone tissue engineering

Noori

Ashrafi

Vaez-Ghaemi

et al. 2017

IJN

368

256

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Tissue engineering has emerged as a new treatment approach for bone repair and regeneration seeking to address limitations associated with current therapies, such as autologous bone grafting. While many bone tissue engineering approaches have traditionally focused on synthetic materials (such as polymers or hydrogels), there has been a lot of excitement surrounding the use of natural materials due to their biologically inspired properties. Fibrin is a natural scaffold formed following tissue injury that initiates hemostasis and provides the initial matrix useful for cell adhesion, migration, proliferation, and differentiation. Fibrin has captured the interest of bone tissue engineers due to its excellent biocompatibility, controllable biodegradability, and ability to deliver cells and biomolecules. Fibrin is particularly appealing because its precursors, fibrinogen, and thrombin, which can be derived from the patient’s own blood, enable the fabrication of completely autologous scaffolds. In this article, we highlight the unique properties of fibrin as a scaffolding material to treat bone defects. Moreover, we emphasize its role in bone tissue engineering nanocomposites where approaches further emulate the natural nanostructured features of bone when using fibrin and other nanomaterials. We also review the preparation methods of fibrin glue and then discuss a wide range of fibrin applications in bone tissue engineering. These include the delivery of cells and/or biomolecules to a defect site, distributing cells, and/or growth factors throughout other pre-formed scaffolds and enhancing the physical as well as biological properties of other biomaterials. Thoughts on the future direction of fibrin research for bone tissue engineering are also presented. In the future, the development of fibrin precursors as recombinant proteins will solve problems associated with using multiple or single-donor fibrin glue, and the combination of nanomaterials that allow for the incorporation of biomolecules with fibrin will significantly improve the efficacy of fibrin for numerous bone tissue engineering applications.

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“…However, with the use of heterologous fibrin sealant (human sealant used in rabbit experiments), markedly delayed vascular ingrowth can be [5]. Vascularization occurs weeks later than in the control groupafter fibrinolysis of the fibrin clot.…”

Section: Bone Graftingmentioning

confidence: 99%

Application of Fibrin Sealant in Orthopedic Surgery

Bösch¹,

Lack²,

Lintner³

1994

Fibrin Sealing in Surgical and Nonsurgical Fields

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We first treated a patient with fibrin sealant in an orthopedic procedure 18 years ago. This was a case of fistulous osteomyelitis following total hip replacement. We packed the bone cavity with homologous spongiosa and fibrin sealant, a technique which has proved successful. In numerous animal experiments and laboratory studies it has been demonstrated that the use of homologous fibrin sealant clearly conduces to the incorporation of bone grafts. This advantage is of particular significance when filling major defects, when no autologous bone is available for grafting, and when combating infections. The fibrin sealant system improves vascularization and this in turn enhances osseous remodeling of bone grafts. The adhesive strength of fibrin sealant is sufficient for refixation of osteochondral fragments. For its hemostatic effect, fibrin sealant is applied to seal major cancellous bone defects or to stanch oozing hemorrhages in patients with bleeding disorders. In cases of ruptured Achilles tendon with extensive necrotic areas, fibrin sealant improves the formation of granulation tissue on the surface of the defect. In general, vascularization and healing are significantly reduced when heterologous fibrin sealants are used.

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Die Beeinflussung der Knochenheilung durch hochkonzentriertes Fibrin

Cited by 51 publications

References 6 publications

Fibrin sealant in bone transplantation: No effects on blood flow and bone formation in dogs

Fibrin sealant in bone transplantation: No effects on blood flow and bone formation in dogs

A review of fibrin and fibrin composites for bone tissue engineering

Application of Fibrin Sealant in Orthopedic Surgery

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