Die Bedeutung des Magnesiumstoffwechsels f�r die Entstehung der L�rmschwerh�rigkeit

Handrock, M.; Fischer, R; Ising, H; Dombrowski, M.

doi:10.1007/bf00501711

Cited by 5 publications

(3 citation statements)

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“…Experimentally induced magnesium (Mg) deficiency has been found to increase noise-induced hearing loss in guinea pigs [7,12,16,17,23] and rats [16,20]. These findings also indicate that Mg as a dietary supplement might reduce auditory susceptibility to noise.…”

Section: Introductionmentioning

confidence: 55%

“…Handrock et al [12] and Ising et al [17] were the first investigators to demonstrate that severe Mg deficiency significantly increases noise-induced hearing loss when compared to animals having normal Mg levels. However, no correlation was found between the hearing loss as found and serum Mg levels which were in part considerably increased by stress [17].…”

Section: Discussionmentioning

confidence: 99%

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Preventive effect of magnesium supplement on noise-induced hearing loss in the guinea pig

Scheibe

Haupt

Ising

2000

European Archives of Oto-Rhino-Laryngology

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The effect of magnesium (Mg) on noise-induced hearing loss was investigated in two groups of adult pigmented guinea pigs maintained either on optimal or suboptimal (physiologically high or low) Mg produced by different diets. The total Mg concentrations of the perilymph (PL), cerebrospinal fluid, blood plasma and red blood cells were measured by atomic absorption spectrometry and were found to differ significantly between the two groups (P < 0.01). One ear of each animal was exposed to either a single shooting impulse at a peak pressure level of 187 dB or two impulse noise series at a rate of 1/s and peak pressure levels of 150 dB (1,000 impulses) and 167 dB (2,280 impulses), respectively. Temporary (TTS) and permanent (PTS) hearing threshold shifts in anesthetized animals were measured 2 h and 1 week after the noise exposure, using auditory brain stem response (ABR) audiometry at a frequency range from 3.75 to 30 kHz. Exposure to the single noise impulse resulted in a mean TTS that was significantly lower in the high Mg group than that in the low Mg group (P < 0.05), although no substantial PTS was observed in either group. In the animals exposed to 150 dB noise, the TTS showed a tendency towards an Mg-related reduction at the higher frequencies. A small difference in PTS was found between the low Mg and high Mg groups, but was not significant. Exposure to the 167-dB noise series caused a considerable TTS, which was significantly lower in the high Mg group at 7.5 and 15 kHz than in the low Mg group (P < 0.05). The mean PTS showed a significant difference between the two Mg groups over the whole frequency range (P < 0.05) and was found to correlate negatively with the total Mg concentrations of both PL and plasma (P < 0.05). Moreover, the high Mg group showed a faster recovery from the hearing threshold shift than the low Mg group. The present findings show that preventive oral Mg supplements can significantly reduce the rate of acoustic trauma caused by high-level impulse noise exposure in the guinea pig.

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Section: Introductionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Preventive effect of magnesium supplement on noise-induced hearing loss in the guinea pig

Scheibe

Haupt

Ising

2000

European Archives of Oto-Rhino-Laryngology

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“…Auditory susceptibility to noise exposure has been found to depend on magnesium (Mg) status, as demonstrated in guinea pigs [6,8,11,12,14,23], rats [13] and humans [1,2]. The mechanisms underlying the effect of Mg on the auditory system are unknown.…”

Section: Introductionmentioning

confidence: 99%

Total magnesium concentrations of perilymph, cerebrospinal fluid and blood in guinea pigs fed different magnesium-containing diets

Scheibe

Haupt

Ising

1999

European Archives of Oto-Rhino-Laryngology

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The total magnesium (Mg) concentrations of the perilymph (PL), cerebrospinal fluid (CSF), plasma and red blood cells (RBCs) of anesthetized guinea pigs separated into three groups and fed different Mg-containing diets were determined by atomic absorption spectrometry. Due consideration was given to the significant sources of error connected with the sampling procedure, particularly contamination of PL with CSF. The Mg levels of the individuals fluids differed significantly (P < 0.05/0.01) within each group. In the normal Mg group, the mean values of the PL, CSF and plasma were 0.66, 0.81 and 0.97 mmol/l, respectively, and 7.83 mmol/kg dry weight for RBCs. The analytical data were found to depend on the Mg content of the animals' diet, but to a different degree in the individual specimens (plasma > PL > CSF). A correlation was found to exist between all specimens tested (P < 0.05/0.01), except for CSF and RBCs, with the closest relation being that between plasma and PL. These findings suggest that the perilymphatic Mg equilibrates with the Mg level of plasma rather than with that of CSF. This is the first report showing Mg data of PL, CSF, plasma and RBCs obtained from the same subject, and the dependency on the Mg content of the animals' diet.

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Pathologie der Innenohrschwerhörigkeiten

Beck

1984

Verhandlungsbericht 1984 Der Deutschen Gesellschaft Für Hals- Nasen- Ohren-Heilkunde, Kopf- Und Hals-Chirurgie

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Die Bedeutung des Magnesiumstoffwechsels f�r die Entstehung der L�rmschwerh�rigkeit

Cited by 5 publications

References 4 publications

Preventive effect of magnesium supplement on noise-induced hearing loss in the guinea pig

Preventive effect of magnesium supplement on noise-induced hearing loss in the guinea pig

Total magnesium concentrations of perilymph, cerebrospinal fluid and blood in guinea pigs fed different magnesium-containing diets

Pathologie der Innenohrschwerhörigkeiten

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