Die Ausbreitung von Tetracyclin im Innenohr nach unterschiedlicher Applikation im Mittelohr

Haug, Hans; Giebel, W.; Breuninger, Helmut

doi:10.1007/bf00455557

Cited by 12 publications

(2 citation statements)

References 9 publications

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“…I25I-serum albumin (Mr 60,000) [17] and ferritin (Mr 445,000) [13], are capable of penetra tion. In addition to RWM passage, certain substances have been shown in the guinea pig to penetrate the very thin bony capsule at the cochlear apex which protrudes into the middle ear [18].…”

Section: Discussionmentioning

confidence: 99%

Hydrocortisone Applied into the Round Window Niche Causes Electrophysiological Dysfunction of the Inner Ear

Spandow

Anniko²,

Hellström³

1989

ORL

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A suspension of 2 % hydrocortisone, micronized in sterile water, was instilled through a perforation in the tympanic membrane into the round window (RW) niche of 9 healthy rats once a day for 5 consecutive days. Three animals were used as controls, and were exposed to sterile water only instilled into the RW niche. Auditory brainstem response (ABR) thresholds were determined for eight frequencies: 2, 4, 6, 8, 12, 16, 20 and 31.5 kHz. Hydrocortisone caused impaired ABR thresholds in the frequency range of 12–31.5 kHz after 5 days of instillation. The impaired thresholds remained unchanged for 2 months, indicating irreversible electrophysiological changes in the inner ear. No morphological damage could be detected in the cochlea by means of light microscopy or transmission electron microscopy. However, hydrocortisone delayed the healing of the perforated tympanic membrane.

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