Die Ätiopathogenese des neurogenen Lungenödem

Šedý, Jiří

doi:10.1007/s10354-010-0759-4

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…In addition, the inhibitory effect of toxins on intracellular respiration can cause extensive hypoxic damage to the myocardium, affecting cardiac function [ 8 ],cardiac hypotrophy contributing to the formation of pulmonary oedema. Brain dysfunction caused by cerebral hypoxia, cerebral oedema, and increased intracranial pressure can cause neurogenic pulmonary oedema [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

Paediatric lung injury due to accidental ingestion of meperfluthrin: a case report

et al. 2022

BMC Pediatr

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Background It is common for children to accidentally ingest chemical drugs with different degrees of toxicity. Meperfluthrin is a highly effective and easy-to-use pyrethroid pesticide with low toxicity. It is widely used in electric mosquito coils. This type of electric mosquito coil is used in daily life, which increases the chance of exposure among children and, consequently, may lead to accidental ingestion. There are only few reports of meperfluthrin poisoning causing lung injury in children. We report a rare clinical case of lung injury wherein a child ingested meperfluthrin orally. Case presentation We report the case of a 1-year-old boy who accidentally swallowed an electric mosquito coil containing meperfluthrin and developed cough and fever. The patient’s parents observed him swallowing the electric mosquito coil (Qiangshou®). Although he was stopped, the child had already swallowed approximately 10 ml of the liquid. According to the instructions, it contained 9 mg/ml of meperfluthrin, thus, it was assumed that he ingested meperfluthrin at a dose of approximately 90 mg. Computed tomography (CT) of his lungs showed uneven brightness in both lungs with multiple spots, scaly shadows, and mesh. Density of the shadows indicated lung parenchymal and interstitial lung disease. Lung tidal function tests indicated obstructive ventilation dysfunction. After evaluation and treatment, his cough drastically reduced, his fever disappeared, and his lung CT findings showed improvement. Therefore, accidental ingestion of meperfluthrin led to acute lung injury in a paediatric patient. Because of prompt treatment, his lung lesions recovered well. Conclusions Meperfluthrin causes airway mucosal damage and hypersensitivity. Lung CT and lung tidal function measurements can be used to monitor changes in the condition. Presently, there is a lack of specific detoxification drugs for meperfluthrin poisoning. Thus, the focus of treatment is to protect the airway mucosa and reduce inflammatory reactions.

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Section: Discussionmentioning

confidence: 99%

Paediatric lung injury due to accidental ingestion of meperfluthrin: a case report

et al. 2022

BMC Pediatr

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“…Cases have been reported in aneurysmal subarachnoid hemorrhage (SAH), traumatic brain injuries, cerebral thrombosis, cerebral gas embolism, intracerebral hemorrhage, intracranial tumors, epilepsy, postoperative intracranial surgery, enterovirus encephalitis, meningitis and multiple sclerosis [2]. The sympathetic system plays a crucial role in the pathogenesis of NPE by activating a rapid cascade of processes leading to interstitial and intraalveolar edema, together with hemorrhage [3].The clinical features can be mistaken for other causes of respiratory failure. Here we present a case of NPE caused by SAH, which was confused priorly with an asthmatic exacerbation due to radiocontrast induced airway hyperresponsiveness during cerebral angiography.…”

Section: Introductionmentioning

confidence: 99%

Neurogenic pulmonary edema accompanying subarachnoid hemorrhage: case report

Yaycı¹,

Deren²,

Tarhan³

et al. 2013

Basic Clin Sci

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Neurogenic pulmonary edema (NPE) is defined as an acute pulmonary edema occurring after a central neurologic insult. It is associated with head injury and seizures, intracranial hemorrhage and stroke are among the other causes. Pathologies increasing intracranial pressure may cause excessive sympathetic discharge and lead to pulmonary vascular pressure changes and transcapillary fluid leakage. Hereby we present an acute respiratory failure in a 50-year old woman with subarachnoid hemorrhage (SAH) due to aneurysmal rupture of anterior communicating artery. The patient had a history of bronchial asthma and respiratory failure was thought to have occurred by radiocontrast induced airway hyper-responsiveness during cerebral angiography. No response to bronchodilator therapy, pinkish foamy sputum from the trachea, diffusely dense infiltrates on both lungs demonstrated by chest X-ray, normal echocardiography, and negative tracheal culture disproving pneumonia were among the factors leading to the diagnosis of NPE. Consistent with the diagnosis, the patient rapidly improved with mechanical ventilation and subsequent removal of the intracranial hematoma. After evaluation of the clinical course of our case, we recommend that NPE should be considered in the differential diagnosis of acute respiratory failure accompanying SAH. Keywords: Neurogenic pulmonary edema, subarachnoid hemorrhage ÖzetNörojenik pulmoner ödem, santral nörojenik travma sonrası oluşan akut pulmoner ödem tablosudur. Kafa travması ile ilişkilidir ve nöbetler, intrakraniyal kanama ve inme diğer

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Die Ätiopathogenese des neurogenen Lungenödem

Abstract: This comment focus on new findings in etiopathogenesis of neurogenic pulmonary edema. It highlights the importance of understanding of pathophysiology as well as proper diagnosis of this clinical entity.

Cited by 2 publications

References 6 publications

Paediatric lung injury due to accidental ingestion of meperfluthrin: a case report

Paediatric lung injury due to accidental ingestion of meperfluthrin: a case report

Neurogenic pulmonary edema accompanying subarachnoid hemorrhage: case report

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