Paediatric lung injury due to accidental ingestion of meperfluthrin: a case report

Li, Zhongqiang; Wu, Xiujie; Lv, Gaomei; Ren, Zhijuan; Yang, Huimin; Xu, Leilei; Guan, Qingli; Meng, Xiuqi

doi:10.1186/s12887-022-03117-4

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…All three patients were treated with corticosteroids, and two showed substantial improvement. In a pediatric case of lung injury caused by the accidental ingestion of meperfluthrin, a type of pyrethroid, inhaled corticosteroids were employed [ 12 ]. If lung injury is mild, inhaled corticosteroids could be a suitable alternative, given their lesser side effects compared to systemic corticosteroid treatment.…”

Section: Discussionmentioning

confidence: 99%

Acute Pneumonitis Associated With the Inhalation of Pyrethroid-Based Domestic Insecticides

Yanagihara¹,

Nakagawa²,

Fukushima³

et al. 2023

Cureus

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We report a 72-year-old female who presented to our hospital with a worsening cough and dyspnea that had emerged a week earlier following the accidental inhalation of a significant quantity of spray-type imiprothrin (a synthetic pyrethroid)-based insecticide in her bathroom. She exhibited acute respiratory failure necessitating 4 L/minute of nasal oxygen at maximum. Chest CT images showed diffuse centrilobular ground-glass opacities with mosaic attenuation and consolidation areas in the lower lobes of both lungs. The patient was diagnosed with acute pneumonitis due to insecticide inhalation, and her symptoms improved following methylprednisolone pulse and alpha-tocopherol therapy. Generally, the accidental inhalation of aerosolized pyrethroids does not induce significant respiratory symptoms, and case reports on pulmonary toxicity related to pyrethroid inhalation are scarce. This case report underscores the need to include inhaled pyrethroid insecticides in the differential diagnosis of patients with acute pneumonitis and suggests that methylprednisolone and alpha-tocopherol therapy can be beneficial for treating this condition.

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Section: Discussionmentioning

confidence: 99%

Acute Pneumonitis Associated With the Inhalation of Pyrethroid-Based Domestic Insecticides

Yanagihara¹,

Nakagawa²,

Fukushima³

et al. 2023

Cureus

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Natural pyrethrins induced developmental toxicity of zebrafish swim bladder in vivo and genotoxicity of lung cells in vitro

Li,

Zhang,

et al. 2024

Toxicology in Vitro

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Systematic review of clinical manifestations, management and outcome following accidental ingestion of liquid mosquito repellent vaporiser in children

Naeem,

Saleem,

Haider Naqvi

et al. 2024

bmjpo

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BackgroundPyrethroid-based mosquito repellents are widely used to control mosquito-borne diseases. Liquid mosquito-repellent vaporisers are effective modes of pyrethroid delivery but can also pose significant health risks if ingested or used improperly.ObjectiveThis systematic review was performed to assess the demographic distribution, clinical presentation, management strategies and outcomes in children resulting from accidental ingestion of liquid mosquito repellent vaporiser.MethodsThe study adheres to the reporting standards outlined in the PRISMA Statement for Systematic Reviews and was prospectively registered with PROSPERO (record # CRD42023413937) to enhance transparency and minimise reporting bias. A comprehensive search was conducted on PubMed, Scopus and Google Scholar using specific MeSH terms related to insecticides, mosquito repellents, pyrethroids, ingestion, poisoning, toxicity and prevention. The reference lists of the included studies were also reviewed for additional relevant articles. The inclusion criteria involved studies published in peer-reviewed journals between 2000 and 2023 that focused on children under 18 years old with a history of mosquito-repellent ingestion based on primary data.ResultsTwelve studies met the inclusion criteria; these were primarily case reports from India, China and the UAE. Male children were predominantly affected, and symptoms included vomiting, convulsions, cough and respiratory distress. Management primarily involved supportive and symptomatic measures, including atropine for salivation and antiepileptic drugs for seizures. Respiratory support was provided for respiratory complications.ConclusionDespite the known risks and diverse presentations of pyrethroid poisoning caused by liquid mosquito repellent vaporiser in children, the limited substantial evidence in the literature underscores the urgent need for comprehensive research to refine management approaches and enhance preventive measures.

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Paediatric lung injury due to accidental ingestion of meperfluthrin: a case report

Cited by 5 publications

References 12 publications

Acute Pneumonitis Associated With the Inhalation of Pyrethroid-Based Domestic Insecticides

Acute Pneumonitis Associated With the Inhalation of Pyrethroid-Based Domestic Insecticides

Natural pyrethrins induced developmental toxicity of zebrafish swim bladder in vivo and genotoxicity of lung cells in vitro

Systematic review of clinical manifestations, management and outcome following accidental ingestion of liquid mosquito repellent vaporiser in children

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