Dicvertin: A new antioxidant and capillary-protecting drug

Kolkhir, V. K.; Tyukavkina, N. A.; Быков, В. А.; Glyzin, V. I.; Арзамасцев, А. П.; Baginskaya, A. I.; Sokolov, S. Ya.; Kolesnik, Yu. A.; Glazova, N. G.; Rulenko, I. A.; Минеева, М. Ф.; Leskova, T. B.; Zyuzin, V. A.; Sakovich, G. S.; Trumpe, T.E.; Khoroshkov, Yu. P.

doi:10.1007/bf02226398

Cited by 13 publications

(12 citation statements)

References 5 publications

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“…DHQ probably suppresses lipid peroxidation [3], which increases the lifetime of cell membranes and organelles. DHQ exhibits other capillary-protecting [2] and antiinflammatory properties, which is associated with inhibition of histamine secretion by mast cells [9]. These properties contribute to wound healing.…”

Section: Resultsmentioning

confidence: 98%

“…c: deformed hair follicle (1). d: sebaceous gland associated with the hair follicle (1); growing hair (2). e: regenerating epithelium (1); damaged hair follicle (2).…”

Section: Resultsmentioning

confidence: 99%

“…Hematoxylin and eosin staining. a: destructed epithelium (1); necrotic masses(2). b: basal layer of the epidermis (1), dividing cells(2); sebaceous glands associated with hair follicles (3).…”

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confidence: 99%

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Effect of Liposomes Containing Antioxidant, Phospholipid, and Amino Acid on Skin Regeneration after Chemical Burn

et al. 2009

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Liposomes containing natural flavonoid dihydroquercetin, phospholipid lecithin, and zwitterionic amino acid glycine were used for the therapy of glacial acetic acid-induced chemical burn. No inflammatory reaction was observed in the region of wound. The area of postburn injury did not increase in time. Planimetry and histological studies showed that improved skin regeneration was accompanied by repair of hair follicles and sebaceous glands.

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Section: Resultsmentioning

confidence: 98%

“…c: deformed hair follicle (1). d: sebaceous gland associated with the hair follicle (1); growing hair (2). e: regenerating epithelium (1); damaged hair follicle (2).…”

Section: Resultsmentioning

confidence: 99%

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Effect of Liposomes Containing Antioxidant, Phospholipid, and Amino Acid on Skin Regeneration after Chemical Burn

et al. 2009

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“…(1) Inactivation of cytotoxic substances [3]; (2) Antidiabetic activity [4]; (3) Termination of free radicals and peroxidation prevention [5,6]; (4) Reduction of lipoprotein content in liver and blood plasma [7]; (5) Antitumour effect [8]; (6) Antimutagene activity ]9]; (7) Antiradiation activity [10]; (8) Immunoregulatory (antiallergic) and anti-inflammatory activity [11,12].…”

Section: Fig 1 Taxifolin (Dihydroquercetin) (Atoms Numeration)mentioning

confidence: 99%

Synthesis and Properties of New Dihydroquercetin Derivatives

Koroteev¹,

Kukhareva²,

Koroteev³

et al. 2015

JPP

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Abstract:This paper is to analyze the latest data on synthesis, structure, chemical and biological properties of flavonoid dihydroquercetin (taxifolin). Complexes including DHQ (dihydroquercetin) into cyclodextrins were obtained. These supramolecular representatives are characterized by high water-solubility, good permeability through biomembranes, prolonged action in the organism and stability while being transported in bloodflow. The use of DHQ in complex with β-cyclodextrin is more promising from the medical point of view than the use of pure DHQ. Total and partial acidylation of DHQ with acid chlorides of aliphatic, aromatic, and heterocyclic carboxylic acids, as well as selective phosphorylation with acid derivatives of trivalent phosphorus (with amides and amidethers of phosphorous acid), and aminomethylation were carried out. DHQ freely undergoes Mannich Reaction with formaldehyde and amines of various structures. The products of the reaction are isolated from the reaction mix with good yield. Isolated aminomethylated derivatives have neurotropic and antiproliferative action.The structure of all synthesized compounds was proved with the help of modern methods of analysis: spectroscopy NMR ( 1 H, 13 C) and XRS. Biological activity of dihydroquercetin modified derivatives was studied. It was found out that some of them are characterized by high cytotoxic, antitumour, and antioxidant biological activity. The inclusion complexes of dihydroquercetin and cyclodextrin were obtained. Acylation, phosphorylation and aminomethylation of dihydroquercetin was performed. The biological activity of obtained compounds was studied.

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“…In application to flavonoid-eontaining phytoprepamtions, the role of these reference compounds is frequently performed by readily available standard samples of rutin [1] or quereetin [2] belonghag to the group of flavonols. Recently, a new standard sample-dihydroquercetin [3], representing the group of hydroxyflavonols, was created in connection with the development of a new antioxidant and capillary-protector phytopreparation diquertin, in which dihydroquercetin is the active substance [4,5].The standard compounds must satisfy high requirements with respect to the degree of purity. Standard substances of the flavonoid nature have to meet another important requiremerit, reflecting the amount and state of water in the compound.…”

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confidence: 99%

Study of the state of water in a standard sample of dihydroquercetin and in the new phytodrug diquertin

et al. 1997

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A reliable way to increase the level of standardization of phytochemical preparations consists in establishing analytical procedures based on officially certified standards represented by compounds of the corresponding chemical nature. In application to flavonoid-eontaining phytoprepamtions, the role of these reference compounds is frequently performed by readily available standard samples of rutin [1] or quereetin [2] belonghag to the group of flavonols. Recently, a new standard sample-dihydroquercetin [3], representing the group of hydroxyflavonols, was created in connection with the development of a new antioxidant and capillary-protector phytopreparation diquertin, in which dihydroquercetin is the active substance [4,5].The standard compounds must satisfy high requirements with respect to the degree of purity. Standard substances of the flavonoid nature have to meet another important requiremerit, reflecting the amount and state of water in the compound. This circumstance is explained by the fact that molecules of the flavonoid compounds contain polar functional groups (carbonyl, hydroxyl) and are capable of interacting with other polar molecules and creating various structural formations. Study of the standard turin and quercetin samples showed that they may contain, depending on the hydrotherreal parameters of the environment, water molecules of the adsorption, "pseudo-crystal-hydrate" and crystal-hydrate nature [6,7].The purpose of this work was to study the amount and character of bound water in the standard dihydroquercetin sample, in the context of characterization of the new phytopreparation diquertin. MATERIALS AND METHODSExperiments were performed on samples ofdihydroquercetin standard and diquertin synthesized at the Irkutsk state University from crushed wood of larch tree [8]. The content of dihydroquercetin in the diquertin sample was 95.4%, and dihydrokaempferol and naringenin accounted for 4.5%. A standard dihydroquercetin sample was obtained by methods of preparative I-IPLC and represented a high-purity compound cor~mlnirtg foreign impurities [9].Thermoanalytical investigations included differential scanning calorimetry (DSC) and thermogravimetric (TG) measurements. To this end, samples weighing 4-5 mg were placed into standard aluminum boats and closed. The desired temperature interval was scanned at a heating rate of 10 K / rain. The total water content was determined by potentiometric titration using the Fischer reagent and by gravimettic determination of the weight loss upon drying to constant weight in a dry box at 105 +__ 2.5~ The sorption of water vapors was studied by exposure of dihydroquercetin and diquertin samples in desiccators above saturated solutions of standard salts, followed by measuring the isotherms of sorption in the static regime and the sorption dynamics in time. RESULTS AND DISCUSSION 94Study of the initial samples showed that the water content in diquertin was several times that in dihydroquercetin (Table 1), albeit still not exceeding the level (not above 7%) stip...

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Dicvertin: A new antioxidant and capillary-protecting drug

Cited by 13 publications

References 5 publications

Effect of Liposomes Containing Antioxidant, Phospholipid, and Amino Acid on Skin Regeneration after Chemical Burn

Effect of Liposomes Containing Antioxidant, Phospholipid, and Amino Acid on Skin Regeneration after Chemical Burn

Synthesis and Properties of New Dihydroquercetin Derivatives

Study of the state of water in a standard sample of dihydroquercetin and in the new phytodrug diquertin

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