2012
DOI: 10.1590/s0102-86502012000200006
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Abstract: PURPOSE:To study diclofenac sodium induced histological and mechanical alterations and their prevention with Imipenem in rat intestine. METHODS: Male Wistar rats (n=240) were randomly assigned to four experimental groups: GI: n=60 treated with 0.9% saline IM; GII: n=60 treated with 6mg/kg body weight diclofenac sodium IM for four days; GIII: n=60 treated with 30mg/kg body weight Imipenem IM for four days, and GIV n=60 treated with diclofenac sodium plus Imipenem at the above doses IM for 4 days. Each group was… Show more

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Cited by 3 publications
(2 citation statements)
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“…Our study agreed with the previous reports 35 , 36 where examination of colonic sections of the control group (group I) revealed normal histological architecture of the mucosa, demonstrating numerous, regularly arranged, evenly spaced and tightly packed crypts. The crypts occupied the whole thickness of the mucosa resting on the muscularis mucosa.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Our study agreed with the previous reports 35 , 36 where examination of colonic sections of the control group (group I) revealed normal histological architecture of the mucosa, demonstrating numerous, regularly arranged, evenly spaced and tightly packed crypts. The crypts occupied the whole thickness of the mucosa resting on the muscularis mucosa.…”
Section: Discussionsupporting
confidence: 93%
“… 34 Ajwa dates contain seed, moisture, fructose, glucose, soluble protein, and fiber and strongly inhibit lipid peroxidation, and cyclooxygenase enzymes and exert potent antioxidant and anti-inflammatory effects. 35 , 36 This agreed with our data that ADFE is rich in polyphenols and flavonoids that exert potent antioxidant effects ( Figure 3A and B ).…”
Section: Discussionsupporting
confidence: 91%