Ameliorative activity of aqueous leaf extract from <i>Madhuca longifolia</i> against diclofenac-administered toxicity on rat stomach and intestine

Simon, Jerine Peter; Sabina, Evan Prince

doi:10.1080/01478885.2020.1861917

Cited by 6 publications

(3 citation statements)

References 37 publications

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“…This showcased the gastroprotective activity of ALEML. The plant's anti-inflammatory activity is attributed to the inhibition of prostaglandin synthesis and reduction of intercellular cell adhesion molecule-1 through TNF-α suppression (12).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Madhuca longifolia var. latifolia (Roxb.) A.Chev: A plant with medicinal boon

Kumar Pandey,

Rakesh

2023

IJAM

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Throughout human history, people used to obtain drugs from natural resources like plants to cure their ailments and improve their health. Nowadays human beings rely more on herbal medicines for the treatment of various ailments because they show better therapeutic activity and have very little to zero side effects on the human body. Madhuca longifolia is also one of the plants used in this category. The plant has been used by people for its medicinal properties since the Ayurveda period (before B.C 300). The plant possesses various medicinal activities including anti-proliferative, anti-inflammatory, anti-bacterial, anti-cancer, anti-ulcer and antidiabetic, and antioxidant activity. In various parts of India, the plant is used in the treatment of different diseases in ethnomedicinal practices. The plant possesses several phytochemicals which are responsible for its medicinal properties. The primary focus of this manuscript is to emphasize the significance of diverse ethnomedical characteristics, multiple preclinical investigations, and clinical trials conducted on this particular plant. The study also encompasses the plant's geographical distribution, pharmacognostic and anatomical studies, as well as its various anthropological applications within the Indian subcontinent.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Madhuca longifolia var. latifolia (Roxb.) A.Chev: A plant with medicinal boon

Kumar Pandey,

Rakesh

2023

IJAM

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“…Silymarin (SLY) is a polyphenolic flavonoid extracted from the fruit and seeds of Sylibum marianum, commonly known as milk thistle [ 20 ]. It is frequently employed for the treatment of hepatic and gallbladder ailments.…”

Section: Introductionmentioning

confidence: 99%

Andrographis paniculata (Burm.f.) Nees Alleviates Methotrexate-Induced Hepatotoxicity in Wistar Albino Rats

Parthasarathy

Sabina

2023

Life

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Andrographis paniculata is a herbal plant used in traditional medicinal approaches to treat various ailments and diseases. Methotrexate (MTX) is a clinically used immunosuppressant and anticancer drug. One of the increasing concerns with MTX use is liver toxicity. The aim of this study is to investigate the potential effect of aqueous leaf extract of Andrographis paniculata against methotrexate-induced hepatotoxicity. Wistar albino rats were grouped into five groups, and the drugs were administered. MTX (20 mg/kg b.w.) was intraperitoneally injected into rats on the ninth day alone. Aqueous leaf extract of Andrographis paniculata (500 mg/kg b.w./day) was orally administered for 10 days. We confirmed the beneficial effect of aqueous extracts of Andrographis paniculata on restoring the hepatic enzyme markers, lipid profile, antioxidant level, anti-inflammatory marker (IL-10), anti-apoptosis (bcl-2), significant suppression of inflammatory cytokines (TNF-α, and IL-6), apoptosis marker (caspase 3) and cellular tissue damage caused by MTX. Overall, we revealed that Andrographis paniculata reduces critical aspects of oxidative stress, inflammatory processes, and apoptosis, thus protecting against methotrexate-induced hepatotoxicity.

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“…Ancak kontrolsüz diklofenak kullanımının karaciğer, mide, bağırsak, testis ve böbrek dokularında serbest radikaller olarak da bilinen reaktif oksijen türleri (ROS) oluşumunu artırdığı, oksidan-antioksidan dengeyi oksidan tarafa kaydırıp doku ve hücre hasarına sebep olduğu bildirilmiştir. [3][4][5][6] Flavonoidler sebze, meyve ve bitki köklerinde bulunan doğal fenolik bileşiklerdir. Kalp-damar hastalıkları, kanser, nörodejeneratif hastalıklar, diyabet gibi birçok hastalığın önlenmesinde ve tedavisinde faydalı etkileri vardır.…”

Section: Introductionunclassified

Erkek Sıçanlarda Diklofenak Kaynaklı Testis Hasarı Üzerine Krisin’in İyileştirici Etkileri

Çağlayan

2022

Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi

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Diklofenak, insanlarda ve hayvanlarda farklı patolojik durumlarla ilişkili akut ve kronik ağrıyı tedavi etmek için kullanılan bir anti-inflamatuar ilaçtır. Aşırı doz ve uzun süreli kullanımı hem insanlarda hem de sıçanlarda erkek üreme organı üzerinde olumsuz etkilere neden olmaktadır. Krisin; bal, propolis ve birçok bitki özünde yaygın olarak bulunan doğal bir fitokimyasaldır. Bu çalışma, erkek sıçanlarda diklofenak kaynaklı testis toksisitesine karşı krisinin koruyucu etkilerini araştırmak için yapıldı. Toplam 35 adet erkek sıçan sırasıyla i) kontrol, ii) krisin, iii) diklofenak, iv) diklofenak + krisin 25, v) diklofenak + krisin 50 grupları olmak üzere 5 gruba eşit olarak ayrıldı. Diklofenakın testis dokusunda kaspaz-3 ve Bcl-2 bağlı X proteini (Bax) gibi apoptotik parametrelerin mRNA transkript seviyelerini artırırken, B-hücreli lenfoma 2 (Bcl-2) mRNA transkript seviyesini azaltarak apoptoza neden olduğu tespit edildi. Ayrıca nükleer faktör eritroid 2 (Nrf-2) ve hem oksijenaz-1 (HO-1) gibi oksidatif stresle ilişkili markırların mRNA transkript seviyelerini azalttı. Yine matriks metalloproteinazların bir üyesi olan matriks metalloproteinaz-2 (MMP2) mRNA transkript seviyeleri diklofenak tarafından arttı. Buna karşın tedavi amacıyla verilen krisin’in yukarıda bahsi geçen parametrelerin seviyeleri üzerine olumlu etki göstererek oksidatif stres ve apoptozu azalttığı belirlendi. Sonuç olarak, bu çalışma krisin’in oksidatif stresi ve apoptozu azaltarak diklofenak kaynaklı testis toksisitesini hafifletebileceğini gösterdi.

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Ameliorative activity of aqueous leaf extract from Madhuca longifolia against diclofenac-administered toxicity on rat stomach and intestine

Cited by 6 publications

References 37 publications

Madhuca longifolia var. latifolia (Roxb.) A.Chev: A plant with medicinal boon

Madhuca longifolia var. latifolia (Roxb.) A.Chev: A plant with medicinal boon

Andrographis paniculata (Burm.f.) Nees Alleviates Methotrexate-Induced Hepatotoxicity in Wistar Albino Rats

Erkek Sıçanlarda Diklofenak Kaynaklı Testis Hasarı Üzerine Krisin’in İyileştirici Etkileri

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