Dickkopf-3: Current Knowledge in Kidney Diseases

Fang, Xiangdong; Hu, Jing; Chen, Yanxia; Shen, Wen; Ke, Ben

doi:10.3389/fphys.2020.533344

Cited by 32 publications

(39 citation statements)

References 44 publications

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“…In particular, in non-dialytic CKD patients, urinary DKK-3 levels have been associated with CKD progression regardless of disease etiology [ 14 ]. Urinary DKK-3 is excreted by the tubular cells under stress and activates the Wnt/β-catenin signaling [ 16 , 17 ]. The Wnt/β-catenin signaling pathway is involved in organ development, tissue homeostasis, and human disease pathogenesis [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, urinary DKK-3 is associated with acute kidney injury and subsequent chronic kidney dysfunction in patients undergoing cardiac surgery [ 15 ]. Urinary DKK-3 levels are a promising marker for predicting RRF decline and assessing the effects of interventions in various kidney diseases [ 16 , 17 ]. However, there are no data on whether urinary levels of DKK-3 are useful for predicting RRF decline in PD patients.…”

Section: Introductionmentioning

confidence: 99%

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Association of Urinary Dickkopf-3 with Residual Renal Function Decline in Patients Undergoing Peritoneal Dialysis

et al. 2021

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Background and Objectives: Urinary levels of dickkopf-3 (DKK-3) are associated with poor renal survival in patients with non-dialytic chronic kidney disease. However, it remains unknown whether urinary DKK-3 levels can predict residual renal function (RRF) decline in patients undergoing peritoneal dialysis (PD). Therefore, we investigated the correlation between urinary levels of DKK-3 and the subsequent rate of RRF decline in PD patients. Materials and Methods: This study included 36 PD patients who underwent multiple peritoneal equivalent tests during 2011–2021. The relationship between baseline clinical characteristics and the subsequent annual rate of Kt/V decline was investigated. Results: The annual rate of renal Kt/V decline was 0.29 (range: 0.05–0.48), which correlated with renal Kt/V (r = 0.55, p = 0.0005) and 24 h urinary DKK-3 excretion (r = 0.61, p < 0.0001). Similarly, 24 h urinary DKK-3 excretion (β = 0.44, p = 0.0015) and renal Kt/V (β = 0.38, p = 0.0059) were independently associated with the annual rate of renal Kt/V decline in multivariate analyses. Conclusions: Urinary DKK-3 assessment may help identify PD patients at a high risk of RRF decline.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Urinary Dickkopf-3 with Residual Renal Function Decline in Patients Undergoing Peritoneal Dialysis

et al. 2021

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“…Dickoppf 3 (DKK3) is a recent promising urinary biomarker in the field of AKI [67] and reflects ongoing tubular injury. High urinary DKK3 levels signify increased risk for (post-cardiac surgery) AKI and further loss of kidney function after an AKI episode [68,69].…”

Section: Novel Biomarkers and Their Possible Impact On Definition And...mentioning

confidence: 99%

Reflections on the KDIGO Definition of Acute Kidney Injury and Its Integration in the Concept of Acute Diseases and Disorders and Chronic Kidney Diseases

Lameire

2022

Kidney and Dialysis

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Acute kidney injury (AKI) describes a heterogeneous group of conditions, without specification of their etiology and diagnosed only by indirect markers of glomerular filtration rate (GFR), such as serum creatinine and urine output. Bedside estimation of GFR and detection of structural alterations with novel biomarkers, and stress tests have more recently been developed. These novel findings should probably be included in future AKI definitions. Chronic kidney disease (CKD) is defined by abnormalities in kidney function and structure that persist over >3 months and is classified according to cause, GFR, and albuminuria. Acute kidney disease (AKD) is the term representing patients with abnormalities of function and structure with a duration of ≤3 months that fall outside the definitions of AKI or CKD. Since AKI is by definition also AKD, 2 types of AKD have been proposed, one with and one without AKI. AKD without AKI is common, often undetected, occurs frequently in the outpatient population and shows increased risk of CKD, ESKD and mortality. Alternatively, AKD has also been defined as the period of incomplete recovery following an AKI episode, the latter limited for the duration of 7 days. This contribution discusses the pros and cons of the existence of these 2 definitions of AKD.

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“…Microflora refers to all the coexisting microorganisms living in the host, which are mainly composed of bacteria, viruses, archaea, fungi, and unicellular eukaryotes (Evenepoel et al, 2017;Castillo-Rodriguez et al, 2018;Cosola et al, 2018). It has been estimated that there are at least 35,000 different microorganisms in the human body (Frank et al, 2007).…”

Section: Gut Microbiotamentioning

confidence: 99%

Advances in the Progression and Prognosis Biomarkers of Chronic Kidney Disease

Yan¹,

Wang²,

Shi³

2021

Front. Pharmacol.

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Chronic kidney disease (CKD) is one of the increasingly serious public health concerns worldwide; the global burden of CKD is increasingly due to high morbidity and mortality. At present, there are three key problems in the clinical treatment and management of CKD. First, the current diagnostic indicators, such as proteinuria and serum creatinine, are greatly interfered by the physiological conditions of patients, and the changes in the indicator level are not synchronized with renal damage. Second, the established diagnosis of suspected CKD still depends on biopsy, which is not suitable for contraindication patients, is also traumatic, and is not sensitive to early progression. Finally, the prognosis of CKD is affected by many factors; hence, it is ineviatble to develop effective biomarkers to predict CKD prognosis and improve the prognosis through early intervention. Accurate progression monitoring and prognosis improvement of CKD are extremely significant for improving the clinical treatment and management of CKD and reducing the social burden. Therefore, biomarkers reported in recent years, which could play important roles in accurate progression monitoring and prognosis improvement of CKD, were concluded and highlighted in this review article that aims to provide a reference for both the construction of CKD precision therapy system and the pharmaceutical research and development.

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Dickkopf-3: Current Knowledge in Kidney Diseases

Cited by 32 publications

References 44 publications

Association of Urinary Dickkopf-3 with Residual Renal Function Decline in Patients Undergoing Peritoneal Dialysis

Association of Urinary Dickkopf-3 with Residual Renal Function Decline in Patients Undergoing Peritoneal Dialysis

Reflections on the KDIGO Definition of Acute Kidney Injury and Its Integration in the Concept of Acute Diseases and Disorders and Chronic Kidney Diseases

Advances in the Progression and Prognosis Biomarkers of Chronic Kidney Disease

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