Dichotomous regulation of group 3 innate lymphoid cells by nongastric
            <i>Helicobacter</i>
            species

Bostick, John W.; Wang, Yetao; Shen, Zeli; Ge, Yong; Brown, J. J.; Chen, Zong ming E.; Mohamadzadeh, Mansour; Fox, James G.; Zhou, Liang

doi:10.1073/pnas.1908128116

Cited by 30 publications

(23 citation statements)

References 42 publications

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“…These species activated ILCs but negatively regulated the proliferation of group 3 RORγt + ILCs that are crucial for host immunity and inflammation. 95 Type 3 ILCs mediate immune surveillance of microbiota configuration to facilitate early colonization resistance through a transcriptional regulator ID2-dependent regulation of IL-22. 96 NCR + ILC3 cells were demonstrated to be essential for maintaining cecal homeostasis in mice during Citrobacter rodentium infection.…”

Section: Interaction Between Microbiota and Immune System In Homeostasismentioning

confidence: 99%

Interaction between microbiota and immunity in health and disease

2020

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The interplay between the commensal microbiota and the mammalian immune system development and function includes multifold interactions in homeostasis and disease. The microbiome plays critical roles in the training and development of major components of the host's innate and adaptive immune system, while the immune system orchestrates the maintenance of key features of host-microbe symbiosis. In a genetically susceptible host, imbalances in microbiota-immunity interactions under defined environmental contexts are believed to contribute to the pathogenesis of a multitude of immune-mediated disorders. Here, we review features of microbiome-immunity crosstalk and their roles in health and disease, while providing examples of molecular mechanisms orchestrating these interactions in the intestine and extra-intestinal organs. We highlight aspects of the current knowledge, challenges and limitations in achieving causal understanding of host immune-microbiome interactions, as well as their impact on immune-mediated diseases, and discuss how these insights may translate towards future development of microbiometargeted therapeutic interventions.

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Section: Interaction Between Microbiota and Immune System In Homeostasismentioning

confidence: 99%

Interaction between microbiota and immunity in health and disease

2020

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“…The interplay of ILCs and the microbiota in mucosal infections plays a determining role in intestinal immunity. Bostick et al 16 showed that enteric Helicobacter species promoted opposing effects on ILCs in immunocompromised mouse models. Both H. apodemus and Helicobacter typhlonius activated ILCs and induced gut inflammation, but negatively regulated proliferation of ILC3s (type 3 ILCs) involved in the innate immune response to extracellular pathogen and diminished their proliferative capacity.…”

Section: Animal Modelsmentioning

confidence: 99%

“…Both H. apodemus and Helicobacter typhlonius activated ILCs and induced gut inflammation, but negatively regulated proliferation of ILC3s (type 3 ILCs) involved in the innate immune response to extracellular pathogen and diminished their proliferative capacity. This dichotomous regulation of ILCs by Helicobacter species in immunocompromised mice constitutes a model for future investigations of the host‐microbe interactions that maintain ILC3s in the intestine 16 and opens new fields of investigation regarding the virulence factor(s) of these enteric Helicobacters that may influence the maintenance of ILC3s in the intestine.…”

Section: Animal Modelsmentioning

confidence: 99%

Review: Other Helicobacter species

Smet

Ménard

2020

Helicobacter

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This review covers the most important, accessible, and relevant literature published between April 2019 and April 2020 in the field of non‐Helicobacter pylori Helicobacter species (NHPH). The initial part of the review covers new insights regarding the presence of gastric and enterohepatic NHPH in humans and animals, while the subsequent section focuses on the progress in our understanding of animal models, the pathogenicity and omics of these species. Over the last year, the clinical relevance of gastric NHPH infections in humans was highlighted. With regard to NHPH in animals, the ancestral source of Helicobacter suis was further established showing that Cynomolgus macaques are the common ancestor of the pig‐associated H. suis population, and 3 novel Helicobacter species isolated from the gastric mucosa of red foxes were described. "Helicobacter burdigaliensis" sp nov. and "Helicobacter labetoulli" sp nov. were proposed as novel enterohepatic Helicobacter species associated with human digestive diseases. An analysis of Helicobacter cinaedi recurrent infections in humans proposed long‐term antibiotic therapies. Several studies using rodent models further elucidated the mechanisms underlying the development of NHPH‐related disease, as well as intestinal immunity in inflammatory bowel disease models. Omics approaches supported Helicobacteraceae taxonomy and unraveled the transcriptomic signatures of H. suis and Helicobacter heilmannii upon adherence to the human gastric epithelium. With regard to virulence, data showed that the nuclear remodeling promoted by cytolethal distending toxin of Helicobacters involves the MAFB oncoprotein and is associated with nucleoplasmic reticulum formation in surviving cells.

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“…negatively regulated RORγt + ILC3, especially T-bet + ILC3, and reduced their proliferative capacity. In contrast, wild type mice could sustain ILC3 function in the presence of Helicobacter spp., indicating an interaction between ILCs and effector T cells [ 112 ]. Hepworth and colleagues recently reported that ILC3 suppress the T cell-dependent IgA response to H. typhlonius in order to preserve the microbial niche [ 76 ].…”

Section: Infections Of the Gastrointestinal Tractmentioning

confidence: 99%

Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border Defense

2020

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Innate lymphoid cells (ILCs) are a recently discovered type of innate immune lymphocyte. They include three different groups classified by the nature of the transcription factors required for their development and by the cytokines they produce. ILCs mainly reside in tissues close to the mucosal barrier such as the respiratory and gastrointestinal tracts. Due to their close proximity to the mucosal surface, ILCs are exposed to a variety of both commensal and pathogenic bacteria. Under non-pathological conditions, ILCs have been shown to be important regulators for the maintenance of tissue homeostasis by mutual interactions with the microbiome. Besides these important functions at homeostasis, several studies have also provided emerging evidence that ILCs contribute to defense against pathogenic bacterial infection by responding rapidly to the pathogens as well as orchestrating other immune cells. In this review, we summarize recent advances in our understanding of the interactions of ILCs and bacteria, with special focus on the function of the different ILC subsets in bacterial infections.

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Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species

Cited by 30 publications

References 42 publications

Interaction between microbiota and immunity in health and disease

Interaction between microbiota and immunity in health and disease

Review: Other Helicobacter species

Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border Defense

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