DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma

Mansouri, Sheila; Singh, Sanjay K.; Alamsahebpour, Amir; Burrell, Kelly; Li, Mira; Karabork, Merve; Ekinci, Can; Koch, Elizabeth; Solaroğlu, İhsan; Chang, Jeffery T.; Wouters, Bradly G.; Aldape, Kenneth; Zadeh, Gelareh

doi:10.18632/oncotarget.10570

Cited by 5 publications

(2 citation statements)

References 72 publications

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“…It is known that the loss or insufficient expression of Drosha, Dicer, and TRBP can lead to the development of a tumor process (Olejniczak et al, 2018). Several groups showed impaired expression of Drosha and Dicer in glioblastoma, pineoblastoma, and neuroblastoma, all of which correlated with a poor prognosis of survival (Lin et al, 2010;Mansouri et al, 2016;de Kock et al, 2020). Decreased expression of these proteins can be mediated by mutations or epigenetic inactivation of their genes.…”

Section: Micrornas Dysregulation In Malignant Primary Brain Tumorsmentioning

confidence: 99%

The Role of MicroRNAs in Therapeutic Resistance of Malignant Primary Brain Tumors

Gareev

Beylerli

Liang

et al. 2021

Front. Cell Dev. Biol.

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Brain tumors in children and adults are challenging tumors to treat. Malignant primary brain tumors (MPBTs) such as glioblastoma have very poor outcomes, emphasizing the need to better understand their pathogenesis. Developing novel strategies to slow down or even stop the growth of brain tumors remains one of the major clinical challenges. Modern treatment strategies for MPBTs are based on open surgery, chemotherapy, and radiation therapy. However, none of these treatments, alone or in combination, are considered effective in controlling tumor progression. MicroRNAs (miRNAs) are 18–22 nucleotide long endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level by interacting with 3′-untranslated regions (3′-UTR) of mRNA-targets. It has been proven that miRNAs play a significant role in various biological processes, including the cell cycle, apoptosis, proliferation, differentiation, etc. Over the last decade, there has been an emergence of a large number of studies devoted to the role of miRNAs in the oncogenesis of brain tumors and the development of resistance to radio- and chemotherapy. Wherein, among the variety of molecules secreted by tumor cells into the external environment, extracellular vesicles (EVs) (exosomes and microvesicles) play a special role. Various elements were found in the EVs, including miRNAs, which can be transported as part of these EVs both between neighboring cells and between remotely located cells of different tissues using biological fluids. Some of these miRNAs in EVs can contribute to the development of resistance to radio- and chemotherapy in MPBTs, including multidrug resistance (MDR). This comprehensive review examines the role of miRNAs in the resistance of MPBTs (e.g., high-grade meningiomas, medulloblastoma (MB), pituitary adenomas (PAs) with aggressive behavior, and glioblastoma) to chemoradiotherapy and pharmacological treatment. It is believed that miRNAs are future therapeutic targets in MPBTs and such the role of miRNAs needs to be critically evaluated to focus on solving the problems of resistance to therapy this kind of human tumors.

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Section: Micrornas Dysregulation In Malignant Primary Brain Tumorsmentioning

confidence: 99%

The Role of MicroRNAs in Therapeutic Resistance of Malignant Primary Brain Tumors

Gareev

Beylerli

Liang

et al. 2021

Front. Cell Dev. Biol.

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“…GSC 8-11: Glioma sphere-forming cells (GSC) 8-11 were isolated from surgical sample from a female patient, following written consent and approval by the institutional review board of The University of Texas M. D. Anderson Cancer Center, and have been characterized in the literature [33]. As reported in the literature [34,35], cells were grown in Neurosphere Media containing DMEM/F12 (Corning, Corning, NY, USA) with B27 (×1, Thermo Fisher Scientific, Waltham, MA, USA), bFGF (20 ng/mL, Millipore Sigma, St.…”

Section: Cell Linesmentioning

confidence: 99%

Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance

Salzillo

Mawoneke

Weygand

et al. 2021

Cells

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Rapid diagnosis and therapeutic monitoring of aggressive diseases such as glioblastoma can improve patient survival by providing physicians the time to optimally deliver treatment. This research tested whether metabolic imaging with hyperpolarized MRI could detect changes in tumor progression faster than conventional anatomic MRI in patient-derived glioblastoma murine models. To capture the dynamic nature of cancer metabolism, hyperpolarized MRI, NMR spectroscopy, and immunohistochemistry were performed at several time-points during tumor development, regression, and recurrence. Hyperpolarized MRI detected significant changes of metabolism throughout tumor progression whereas conventional MRI was less sensitive. This was accompanied by aberrations in amino acid and phospholipid lipid metabolism and MCT1 expression. Hyperpolarized MRI can help address clinical challenges such as identifying malignant disease prior to aggressive growth, differentiating pseudoprogression from true progression, and predicting relapse. The individual evolution of these metabolic assays as well as their correlations with one another provides context for further academic research.

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DICER1 mutations in primary central nervous system tumors: new insights into histologies, mutations, and prognosis

Liu

Cacciotti

et al. 2022

J Neurooncol

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DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma

Cited by 5 publications

References 72 publications

The Role of MicroRNAs in Therapeutic Resistance of Malignant Primary Brain Tumors

The Role of MicroRNAs in Therapeutic Resistance of Malignant Primary Brain Tumors

Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance

DICER1 mutations in primary central nervous system tumors: new insights into histologies, mutations, and prognosis

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