Dibutyrylchitin nanoparticles as novel drug carrier

Jain, Tanvi; Kumar, Sushil; Dutta, Pradip Kumar

doi:10.1016/j.ijbiomac.2015.11.031

Cited by 25 publications

(11 citation statements)

References 33 publications

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“…This study has shown that AuNPs synthesized from CM extract are hemocompatible. No more than 10% of hemolysis was observed for all tested concentrations up to 50 µg/mL, which is below the safe hemolytic ratio for biomaterials according to ISO/TR7406 [39]. The aggregation of RBC was also not observed for all concentrations of AuNPs tested.…”

Section: Discussionmentioning

confidence: 79%

Curcuma mangga-Mediated Synthesis of Gold Nanoparticles: Characterization, Stability, Cytotoxicity, and Blood Compatibility

et al. 2017

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The utilization of toxic chemicals as reducing and stabilizing agents in the preparation of gold nanoparticles (AuNPs) has increased in vivo toxicity and thus limited its application in clinical settings. Herein, we propose an alternative method of preparing highly stable AuNPs, where non-toxic Curcuma mangga (CM) extract was used as a single reducing and stabilizing agent to overcome the aforementioned constraints. The morphological images enunciated that the homogeneously dispersed AuNPs exhibited spherical morphology with an average particle diameter of 15.6 nm. Fourier Transform infrared (FTIR) and cyclic voltammetry analysis demonstrated that carbonyl groups of terpenoids in CM extract played an important role in the formation and stabilization of AuNPs. Green-synthesized AuNPs were found to have good stability in physiological media after 24 h of dispersion. The AuNPs were also cytocompatible with human colon fibroblast cell (CCD-18Co) and human lung fibroblast cell (MRC-5). Hemocompatibility tests revealed that the AuNPs were blood-compatible, with less than 10% of hemolysis without any aggregation of erythrocytes. The current study suggests potential in employing a CM-extract-based method in the preparation of AuNPs for anticancer diagnosis and therapy.

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Section: Discussionmentioning

confidence: 79%

Curcuma mangga-Mediated Synthesis of Gold Nanoparticles: Characterization, Stability, Cytotoxicity, and Blood Compatibility

et al. 2017

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“…High NC loading will be important for molecular imaging applications. These DBC particles reported herein had a hydrodynamic diameter larger than other DBC particles reported in the literature; diameter ~ 100 nm [35]. Although in the oil-in-water emulsion process we utilized larger particles were formed, our technique provides an alternative encapsulation strategy for labile drugs and proteins, due to the lower amplitudes and sonication time involved.…”

Section: Discussionmentioning

confidence: 90%

“…While chitin is a promising biomaterial, DBC is also highly biocompatible and it can be degraded by enzymes [35]. Moreover, it has wound-healing and antibacterial properties [36].…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of magnetic and fluorescent chitin and dibutyrylchitin sub-micron particles by oil-in-water emulsification

et al. 2016

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Chitin is a carbohydrate polymer with unique pharmacological and immunological properties, however, because of its unwieldy chemistry, the synthesis of discreet sized sub-micron particles has not been well reported. This work describes a facile and flexible method to fabricate biocompatible chitin and dibutyrylchitin sub-micron particles. This technique is based on an oil-in-water emulsification/evaporation method and involves the hydrophobicization of chitin by the addition of labile butyryl groups onto chitin, disrupting intermolecular hydrogen bonds and enabling solubility in the organic solvent used as the oil phase during fabrication. The subsequent removal of butyryl groups post-fabrication through alkaline saponification regenerates native chitin while keeping particles morphology intact. Examples of encapsulation of hydrophobic dyes and nanocrystals are demonstrated, specifically using iron oxide nanocrystals and coumarin 6. The prepared particles had diameters between 300-400 nm for dibutyrylchitin and 500-600 nm for chitin and were highly cytocompatible. Moreover, they were able to encapsulate high amounts of iron oxide nanocrystals and were able to label mammalian cells.

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“…Regarding nanotechnology-related drug delivery applications, chitin and its derivatives have attracted remarkable attention from the scientific community. Thus, considering the challenges of current therapies (in terms of drug resistance and systemic or topic side effects) and the processing versatility of chitin-derived compounds, various research studies have reported successful data regarding chitin-based nanostructures for controlled and/or targeted delivery of antibiotics [40,41,42], antivirals [43], antifungals [44,45,46], anti-inflammatory [47,48] and anti-tumor substances [38,43,49,50].…”

Section: Introductionmentioning

confidence: 99%

Fabrication, Characterization, and Evaluation of Bionanocomposites Based on Natural Polymers and Antibiotics for Wound Healing Applications

et al. 2016

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Abstract:The aim of our research activity was to obtain a biocompatible nanostructured composite based on naturally derived biopolymers (chitin and sodium alginate) loaded with commercial antibiotics (either Cefuroxime or Cefepime) with dual functions, namely promoting wound healing and assuring the local delivery of the loaded antibiotic. Compositional, structural, and morphological evaluations were performed by using the thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and fourier transform infrared spectroscopy (FTIR) analytical techniques. In order to quantitatively and qualitatively evaluate the biocompatibility of the obtained composites, we performed the tetrazolium-salt (MTT) and agar diffusion in vitro assays on the L929 cell line. The evaluation of antimicrobial potential was evaluated by the viable cell count assay on strains belonging to two clinically relevant bacterial species (i.e., Escherichia coli and Staphylococcus aureus).

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Dibutyrylchitin nanoparticles as novel drug carrier

Cited by 25 publications

References 33 publications

Curcuma mangga-Mediated Synthesis of Gold Nanoparticles: Characterization, Stability, Cytotoxicity, and Blood Compatibility

Curcuma mangga-Mediated Synthesis of Gold Nanoparticles: Characterization, Stability, Cytotoxicity, and Blood Compatibility

Fabrication of magnetic and fluorescent chitin and dibutyrylchitin sub-micron particles by oil-in-water emulsification

Fabrication, Characterization, and Evaluation of Bionanocomposites Based on Natural Polymers and Antibiotics for Wound Healing Applications

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