Fabrication, Characterization, and Evaluation of Bionanocomposites Based on Natural Polymers and Antibiotics for Wound Healing Applications

Rădulescu, Marius; Holban, Alina Maria; Mogoantă, Laurențiu; Bălşeanu, Tudor-Adrian; Mogoşanu, George Dan; Savu, Diana; Popescu, Roxana Cristina; Fufă, Oana; Grumezescu, Alexandru Mihai; Bezirtzoglou, Eugenia; Lazăr, Veronica; Chifiriuc, Mariana Carmen

doi:10.3390/molecules21060761

Cited by 29 publications

(16 citation statements)

References 66 publications

(67 reference statements)

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“…The integrated complexes must show a dynamic role in the wound healing process either as helping the removal of necrotic tissues, preventing/treating installed infections, or both. In this respect, dressings can be functionalized with many classes of antibiotics (such as quinolones [ 10 ], tetracyclines [ 11 ], aminoglycosides [ 12 ], cephalosporins [ 13 ], etc.) or other substances that exhibit antibacterial properties (e.g., essential oils) [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment Strategies for Infected Wounds

2018

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The treatment of skin wounds is a key research domain owing to the important functional and aesthetic role of this tissue. When the skin is impaired, bacteria can soon infiltrate into underlying tissues which can lead to life-threatening infections. Consequently, effective treatments are necessary to deal with such pathological conditions. Recently, wound dressings loaded with antimicrobial agents have emerged as viable options to reduce wound bacterial colonization and infection, in order to improve the healing process. In this paper, we present an overview of the most prominent antibiotic-embedded wound dressings, as well as the limitations of their use. A promising, but still an underrated group of potential antibacterial agents that can be integrated into wound dressings are natural products, especially essential oils. Some of the most commonly used essential oils against multidrug-resistant microorganisms, such as tea tree, St. John’s Wort, lavender and oregano, together with their incorporation into wound dressings are presented. In addition, another natural product that exhibits encouraging antibacterial activity is honey. We highlight recent results of several studies carried out by researchers from different regions of the world on wound dressings impregnated with honey, with a special emphasis on Manuka honey. Finally, we highlight recent advances in using nanoparticles as platforms to increase the effect of pharmaceutical formulations aimed at wound healing. Silver, gold, and zinc nanoparticles alone or functionalized with diverse antimicrobial compounds have been integrated into wound dressings and demonstrated therapeutic effects on wounds.

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Section: Introductionmentioning

confidence: 99%

Treatment Strategies for Infected Wounds

2018

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“…; Rădulescu et al . ). Studies on chitin and chitosan have been intensified since 1990, because these polysaccharides exhibit excellent biological and physicochemical properties such as biocompatibility, nontoxicity, biodegradability, antimicrobial, antioxidant and antitumor activities, high thermal stability and fibrous and porous surface morphology (Younes & Rinaudo ).…”

Section: Introductionmentioning

confidence: 99%

“…Chitin is the second most diverse and abundantly founded natural biopolymer on the planet (Marei et al 2016). Chitin exists in skeletal structures of various creatures including algae, fungi, Anthozoa (corals), Porifera (marine and freshwater sponges), Annelida, Mollusca, Nematode and arthropods (Insecta, Crustacea, and Arachnida) (Southward et al 2005;Ehrlich et al 2007;Rădulescu et al 2016). Studies on chitin and chitosan have been intensified since 1990, because these polysaccharides exhibit excellent biological and physicochemical properties such as biocompatibility, nontoxicity, biodegradability, antimicrobial, antioxidant and antitumor activities, high thermal stability and fibrous and porous surface morphology (Younes & Rinaudo 2015).…”

Section: Introductionmentioning

confidence: 99%

Extraction of high thermally stable and nanofibrous chitin from Cicada (Cicadoidea)

Mol

Kaya

Mujtaba

et al. 2018

Entomological Research

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Due to the increasing interest in natural biopolymers including chitin, the exploitation of economic and easily accessible chitin sources with good physicochemical properties is nowadays required. In view of this fact, in the current study chitin was extracted and physicochemically characterized from six Cicadas (Hemiptera: Homoptera: Cicadoidea) species collected from Mediterranean region of Turkey (2014–15). Chitin was extracted using a classic extraction method that includes acid and base treatment. TGA results revealed a remarkable increase (410–412°C) for all the six Cicada species compared to other chitin samples extracted from various sources. For all of the six selected species the chitin contents on the dry basis were determined as 6.7% for Cicadatra atra, 5.51% for C. hyalina, 8.84% for C. platyptera, 4.97% for Cicada lodosi, 6.49% for C. mordoganensis, and 5.88% for Cicadetta tibialis. The surface morphology of chitin isolates from Cicada species was observed to consist of nanofibers and nanopores.

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“…The in vitro cytotoxicity evaluation of the PANI-LIG-based thin coatings was done for osteoblast-like cells (MG-63) (ATCC, Manassas, VA, USA) [ 39 ] and [ 40 ]. Samples were sterilized by UV exposure during 1 h and washed with complete culture medium (Eagle’s MEM- Biochrom, supplemented with 10% FBS, 1% L-glutamine, 1% P/S, and 1% NEAA at 37 °C) during 10 min.…”

Section: Methodsmentioning

confidence: 99%

Laser Processed Antimicrobial Nanocomposite Based on Polyaniline Grafted Lignin Loaded with Gentamicin-Functionalized Magnetite

et al. 2019

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Composite thin coatings of conductive polymer (polyaniline grafted lignin, PANI-LIG) embedded with aminoglycoside Gentamicin sulfate (GS) or magnetite nanoparticles loaded with GS (Fe3O4@GS) were deposited by the matrix-assisted pulsed laser evaporation (MAPLE) technique. The aim was to obtain such nanostructured coatings for titanium-based biomedical surfaces, which would induce multi-functional properties to implantable devices, such as the controlled release of the therapeutically active substance under the action of a magnetic and/or electric field. Thus, the unaltered laser transfer of the initial biomaterials was reported, and the deposited thin coatings exhibited an appropriate nanostructured surface, suitable for bone-related applications. The laser processing of PANI-LIG materials had a meaningful impact on the composites’ wettability, since the contact angle values corresponding to the composite laser processed materials decreased in comparison with pristine conductive polymer coatings, indicating more hydrophilic surfaces. The corrosion resistant structures exhibited significant antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans strains. In vitro cytotoxicity studies demonstrated that the PANI-LIG-modified titanium substrates can allow growth of bone-like cells. These results encourage further assessment of this type of biomaterial for their application in controlled drug release at implantation sites by external activation.

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Fabrication, Characterization, and Evaluation of Bionanocomposites Based on Natural Polymers and Antibiotics for Wound Healing Applications

Cited by 29 publications

References 66 publications

Treatment Strategies for Infected Wounds

Treatment Strategies for Infected Wounds

Extraction of high thermally stable and nanofibrous chitin from Cicada (Cicadoidea)

Laser Processed Antimicrobial Nanocomposite Based on Polyaniline Grafted Lignin Loaded with Gentamicin-Functionalized Magnetite

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