Dibromochloropropane (DBCP): An 8-year reevaluation of testicular function and reproductive performance

Potashnik, G.; Yanai‐Inbar, Ilana

doi:10.1016/s0015-0282(16)50012-0

Cited by 94 publications

(15 citation statements)

References 11 publications

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“…This is because the substance has been banned from use in most countries, and (to my knowledge) no further data on the effects of human exposure have since emerged. Potashnik and Yanai-Inbar (1987) reported that they had conducted more than one study and that the later work confirmed their original result. Vinclozolin, borates, alcohol and professional driving: These data are included not because they are persuasive of my point, but because they are compatible with it.…”

Section: Article In Pressmentioning

confidence: 81%

Possible constraints on adaptive variation in sex ratio at birth in humans and other primates

James

2006

Journal of Theoretical Biology

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Section: Article In Pressmentioning

confidence: 81%

Possible constraints on adaptive variation in sex ratio at birth in humans and other primates

James

2006

Journal of Theoretical Biology

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“…Hormonally induced ovulation leads to a clear reduction in the sex ratio of offspring [47], a result that has also been found following paternal exposure to the nematocide dibromochloropropane [23,24]. Paternal, but not maternal, exposure to dioxin following an explosion at an herbicide factory in Seveso, Italy was found to reduce the sex ratio [26,27].…”

Section: Discussionmentioning

confidence: 99%

Decreased sex ratio following maternal exposure to polychlorinated biphenyls from contaminated Great Lakes sport-caught fish: a retrospective cohort study.

2003

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“…However, recovery of testicular function among workers exposed to DBCP has been reported. 14,15 Examining the prostate and seminal vesicle weights re¯ects changes in the animal's endocrine status, since the weight of both organs is androgen-dependent. In the sexually mature rats, the serum testosterone concentration was signi®cantly decreased after all the doses used.…”

Section: Discussionmentioning

confidence: 99%

Male reproductive toxicity and b-luteinizing hormone gene expression in sexually mature and immature rats exposed to 2-bromopropane

Faqi

Yang³

et al. 1999

Hum Exp Toxicol

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1 The reproductive effects of 2-bromopropane (2-BP) in sexually mature and immature male Sprague-Dawley rats were investigated. The animals were randomly divided into three treatment groups and one control group each of which comprised six mature and six immature rats. The treated groups were injected s.c. 200, 600 and 1800 mg/kg of 2-BP on 5 days a week for 5-7 weeks and the control group received the vehicle. 2 The absolute and relative testis weights were significantly reduced in 600 and 1800 mg/kg b.w. dose groups in both mature and immature rats. The absolute epididymis, prostate, seminal vesicle, and pituitary weights and the relative epididymis weights, however, were significant only at the highest dose level used in both mature and immature rats. 3 The sperm concentration and sperm viability in epididymal duct decreased and the percentage of abnormal sperm increased in a dose-dependent manner in both mature and immature rats. Additionally, serum testosterone level was significantly decreased in all dose groups in mature rats, and was significantly reduced only in the group treated with the middle and highest dose in immature rats. 4 In both mature and immature rats treated with 200 and 600 mg/kg, the seminiferous tubules were atrophied and all types of germ cells were decreased in number. At the highest dose level, the effect was more marked showing severely atrophied seminiferous tubules and a complete loss of all types of germ cells. 5 The mating, pregnancy and fertility indices were significantly reduced in the 600 and 1800 mg/kg groups. Additionally, at the highest dose group the number of implantations and viable fetuses per litter were reduced and the resorption rate was increased significantly. 6 In the mature rats, the b-LH gene expression increased significantly in the 1800 mg/kg group when compared to the control group. 7 It can be concluded that 2-BP induces alterations in both neuro-endocrine axis and the reproductive tract under the present experimental conditions. The no observed adverse effect level (NOAEL) in this study could be estimated to be lower than 200 mg/kg/b.w. based on the alteration in testicular morphology as well as on sperm parameters observed at the dose level of 200 mg/kg.

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Dibromochloropropane (DBCP): An 8-year reevaluation of testicular function and reproductive performance

Cited by 94 publications

References 11 publications

Possible constraints on adaptive variation in sex ratio at birth in humans and other primates

Possible constraints on adaptive variation in sex ratio at birth in humans and other primates

Decreased sex ratio following maternal exposure to polychlorinated biphenyls from contaminated Great Lakes sport-caught fish: a retrospective cohort study.

Male reproductive toxicity and b-luteinizing hormone gene expression in sexually mature and immature rats exposed to 2-bromopropane

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