Diazocoupling reaction for the spectrophotometric determination of physiologically active catecholamines in bulk and pharmaceutical preparations

Sensitive Electrochemical Sensor for Determination of Methyldopa Based on Polypyrrole/Carbon Nanoparticle Composite Thin Film Made by In Situ Electropolymerization

“…Compared to the bare GCE, the electrochemical response of PPy/CNP/ GCE reduces in the presence of the negatively charged analytes like Fe(CN) 6 4À (Figure 2A), but considerably in- creases when a positively charged analyte such as Ru(PPy) 3 2 + is present ( Figure 2B). This can be related to electrostatic interaction between the negative charge density of the modified film and the analytes, as it has been discussed in the literature for over-oxidized polypyrrole [39].…”

“…Ascorbic acid (AA) and Potassium ferrocyanide (K 4 Fe(CN) 6 ) were purchased from Merck. Ru(bpy) 3 Cl 2 was synthesize in our laboratory based on a reported procedure [37]. 3-(3,4-Dihydroxyphenyl)-2-methyl-l-alanine (methyl-l-dopa) was purchased from Fluka (Scheme 1).…”

“…As blood vessels relax, m-dopa relieves high blood pressure [1]. Several techniques have been reported in the literatures for the determination of m-dopa [2][3][4], but electrochemical methods have attracted great interests because of their simplicity, rapidness and high sensitivity in determination of m-dopa and various other analytes, without any tedious pre-treatments [5][6][7].…”

Green adherent spectrophotometric determination of molnupiravir based on computational calculations; application to a recently FDA-approved pharmaceutical dosage form

“…Among the color-based spectrophotometric methods, diazotization coupling is generally used for the determination of compounds containing free aromatic amino groups. The reaction is based on the coupling of the diazonium salts with various coupling agents [31] , [32] , [33] , [34] . It is believed that the selection of the best coupling agent can improve the spectrophotometric determination of the compound of interest.…”

Colorimetric estimation of alfuzosin hydrochloride in pharmaceutical preparation based on computational studies

“…Virtually all drug molecules possess one or more functional groups that can be analyzed in some fashion. 24,25 However, although the last decade's analytical chemists have developed a variety of visible spectrophotometric techniques for the estimation of pharmaceutical products, evidently this eld has become very sophisticated and a lot of reagents have been synthesized either by analytical chemists or organic chemists. Extremely little attention has been paid to the application of computational modeling and theoretical studies for the choice of the most selective and optimum reagent of different reactions applicable for visible spectrophotometric estimation of drugs.…”