Diazinon toxicity affects histophysiological and biochemical parameters in rabbits

Yehia, Mohamed; El-Banna, Sabah G; Okab, Aly B.

doi:10.1016/j.etp.2007.09.003

Cited by 68 publications

(35 citation statements)

References 23 publications

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“…OP insecticides are known to induce various histopathological changes in the liver tissues 48 and indeed we found by light microscopic analyses that malathion-induced hyperplasia of epithelial lining bile duct and fibroplasia in portal triad and Kupffer cell activation and focal hepatic necrosis associated with inflammatory cells infiltration and focal hepatic necrosis associated with inflammatory cells infiltration as well as apoptosis of hepatocytes in Liver sections of animals treated with ML when compared with control group. On the other hand Kidneys sections of animals treated with ML alone showed congestion of glomerular tuft, perivascular oedema associated with inflammatory cells infiltration in kidneys when compared with control group.…”

Section: Discussionmentioning

confidence: 88%

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

El-Raheem¹

2015

MOJT

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It has been confirmed that organophosphorus compounds OP altered glucose homeostasis. Considerable experimental and clinical evidences have contributed the beneficial effects of antioxidant compounds in plant extract on hepatorenal toxicity. The aim of this study was to evaluate whether Melissa officinalis extract, was able to ameliorative hepatorenal injury induced by organophosphorus Malathion. Malathion at 27mg/kg bw was administered to rats alone or in combination with Melissa officinalis extract at 200mg/kg bw. Malathion decreases feed intake and body weight as well as liver and kidneys weight. Moreover, Malathion increases the levels of various serum marker enzymes AST, ALT and ALP. A significant increase in the level of serum urea, uric acid and creatinine in response to ML treatment. As well as ML induced increase in MDA in liver and kidneys while induced decreases in the activities of SOD, GPx and CAT. Co-administration of malathion with Melissa officinalis extract resulted in restoration of all tested parameter. These results may be due to the significant increase recorded in acetylcholine esterase (Ach E) activity invivo after co administration of malathion and Melissa officinalis extract. In histological study of liver and kidney, Malathion induced damage in liver and kidneys. However, MO administration to ML-treated animals resulted in overall improvement in liver and kidneys damage, emphasizing its antioxidant role. In light of the available data, it can deduce that ML-induced lipid peroxidation, oxidative stress, liver and kidneys damage rats, and conjoint supplementation of MO has resulted in pronounced ameliorating effect in all tested parameter and histological picture of liver and kidney. MOJ Toxicology Research ArticleOpen Access Ameliorative role of melissa officinalis against hepatorenal toxicities of organophosphorus malathion in male rats 104Copyright: ©2015 Sief et al. Citation:Sief MM, Khalil FA, Abou-Arab AA, et al. Ameliorative role of melissa officinalis against hepatorenal toxicities of organophosphorus malathion in male rats.

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Section: Discussionmentioning

confidence: 88%

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

El-Raheem¹

2015

MOJT

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“…In histopathological examination, DMBA caused severe sinusoidal dilatation and severe vacuolation, inflammation around the portal area and central vein and disrupted the radial alignment around the central vein in hepatocytes. Silibinin significantly reversed the DMBA-induced sinusoidal dilatation, severe vacuolization and inflammation around the central vein in hepatocytes (P < 0.05) (Yehia et al, 2007 andAlp et al, 2011). The liver is a very crucial organ for the detoxification processes and oxidative stress is thought to be a key mechanism of hepatocellular injury.…”

Section: Hepatocytes Of Control Groupmentioning

confidence: 99%

Influence of Sibinin on DMBA Induced Hepatotoxicity and Free-Radical Damage in Norwegian Rat, Rattus norvegicus (L).

Khyade¹

2017

Int.J.Curr.Microbiol.App.Sci

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“…Pesticides are the most effective means of pest eradication all over the world, but their use has reached an alarming rate due to a number of adverse effects on non-target organisms (1)(2)(3). For the last few decades, pyrethroid pesticides have strengthened their place in the pesticide market for several uses.…”

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confidence: 99%

Biochemical and Histological Changes in Rat Liver Caused by Cypermethrin and Beta-Cyfluthrin

Bhushan

Saxena

2013

Archives of Industrial Hygiene and Toxicology

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Cypermethrin and beta-cyfl uthrin are two most widely used multipurpose pyrethroids. After determining their oral LD 50 (416.98 mg kg -1 and 354.8 mg kg -1 body weight, respectively), we assessed their hepatotoxicity in Wistar rats following acute (0.1 LD 50 for 1 day) and sub-acute (0.1 LD 50 for 7, 14, 21 or 28 days) poisoning. The assessment was based on hepatic marker enzymes AST, ALT, LDH, ALP, glycogen, total proteins, total lipids, cholesterol, free fatty acids, and phospholipids. AST, ALT, LDH, total lipids, cholesterol, phospholipids, and free fatty acids in hepatic homogenate increased following pyrethroid stress. In contrast, hepatic proteins, glycogen, and ALP activity decreased due to lysis of structural proteins and leakage of enzymes into the blood stream. Biochemical data were consistent with histological alterations (cytoplasmic vacuolisation, nuclear polymorphism, eccentric nucleus, karyolysis, karyorrhexis, and sinusoidal dilation). Comparatively greater hepatocellular damage was noted in beta-cyfl uthrin than in cypermethrin-treated rats, which is probably related to the fl uorine atom in beta-cyfl uthrin.

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Diazinon toxicity affects histophysiological and biochemical parameters in rabbits

Cited by 68 publications

References 23 publications

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

Influence of Sibinin on DMBA Induced Hepatotoxicity and Free-Radical Damage in Norwegian Rat, Rattus norvegicus (L).

Biochemical and Histological Changes in Rat Liver Caused by Cypermethrin and Beta-Cyfluthrin

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