Diazepam (Valium) as a Muscle Relaxant During General Anaesthesia: A Pilot Study

Hunter, A. R.

doi:10.1093/bja/39.8.633

Cited by 17 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings of the present study on the interaction of diazepam and d-tubocurarine in human beings are in conformity with those of Stovner and Endreson (19{) Hunter (1967) and Dretchen et al (1971). However, Stovner and Endreson (1965b), Moore (1968), Feldman and Crawley (1970a, 1970b and Yergano et al (HHO) found that diazepam potentiated the effect of small doses of specific neuromuscular blocking agents.…”

Section: Disccssiol\supporting

confidence: 91%

Effect of Diazepam on Neuromuscular Transmission and its Interaction with Non-Depolarizing Muscle Relaxants

Jain

Pandey

1976

Anaesth Intensive Care

View full text Add to dashboard Cite

Sl'~nL\\{Y-,"cltroll/ltsclIlar !Jlockillg actiolls of dia:;cpam awi its interaction with some myonellral h/ockillg agents 7cere stw/ied ill dogs and /1/ humalls undcrr;oillg surgery under r;cneral allllcsthcsia. J)iazepillll alonc had 110 effect Oil the response of tibialis anterior 1Iluscle to illdirt'Ct stimulatioll in dor;s. Ar;aill, diazepam ill a bolus dose of 5 mg did not illfluence a prc-c.ristillr; partial bloc/, hy d-tllhocllrarine, gallamine or panCl/rOllilllll. Bl/t a significallt ill crease ill both the degree and dllratioll of block 7f'as observed 7f'izCIl diazepam and d-tubocurarine 7£'crc r;i7'cn simultancollsly, Sltr;r;csting all agollist action in diazepam. On thc colltrary, simllltaneolls IIse of dia:;cpaJll and gallamine caused a sigllifical/tly less il1tense block of tihia/is mllscle beitch tension as compared to gallamine alonc, suggestinr; all antagonistic action. Thc dcr;rcc and dltratioll of block by d-tubocllrarine 7f'ere not affected significantly by simllltalleolls admi1listratiol1 of diazepam in human beings. It is, therefore, concluded that diazepam ill clillical dost's call be safely used 7('ith d-tllbocllrarille in hlllllmls.

show abstract

Section: Disccssiol\supporting

confidence: 91%

Effect of Diazepam on Neuromuscular Transmission and its Interaction with Non-Depolarizing Muscle Relaxants

Jain

Pandey

1976

Anaesth Intensive Care

View full text Add to dashboard Cite

show abstract

“…Displacement of the carbon dioxide response lines appeared to be a better method of assessing our drugs. The respiratory depression caused by diazepam, when administered as an induction agent or during anaesthesia, has been well documented (McClish, 1966;Hunter, 1967). However, experimental studies, in man, on the effects of diazepam upon the ventilatory response to carbon dioxide has produced variable results.…”

Section: Animal Studiesmentioning

confidence: 99%

Benzoctamine–a Study of the Respiratory Effects of Oral Doses in Human Volunteers and Interactions With Morphine in Mice

Utting¹,

Pleuvry²

1975

British Journal of Anaesthesia

View full text Add to dashboard Cite

A double-blind trial has been performed to investigate the respiratory effects of low oral doses of benzoctamine, and to compare them with diazepam and a placebo. The displacement of the carbon dioxide response curves indicated that whilst diazepam caused respiratory depression, benzoctamine had a variable effect. Some volunteers showed depression, but most showed stimulation. Peak respiratory effects were seen 1 hr after oral administration, returning to normal 2-3 hr after administration. It is suggested that oral drugs given for premedication need to be administered at least 2 hr before operation to obtain maximum sedative effects at a time when respiratory effects are returning to normal. In animal experiments it has been shown that the analgesic actions of morphine are diminished by concurrent administration of benzoctamine, and that the depression of respiratory rate caused by morphine is enhanced.

show abstract

“…It is notable that the administration of respiratory depressant drugs to anaesthetized patients is associated with a greater degree of respiratory depression than would be predicted from their effect on PCO2 and ventilation in conscious volunteers (Potter and Payne, 1970). For example, in one study (Hunter, 1967) respiratory arrest occurred in three of 13 patients given diazepam 2.5-10mg during anaesthesia with nitrous oxide, oxygen and halothane, whereas the effect of diazepam 15mg on resting end-tidal PCO 2 in normal volunteers was to produce only a small increase of 0.2 kPa (Jordan, Lehane and Jones, 1980). Using magnetometers, Tusiewicz, Bryan and Froese, (1977) showed that halothane anaesthesia considerably diminished the rib cage contribution during quiet breathing, a finding supported by Jones and colleagues (1979) using mercury-insilastic strain gauges.…”

Section: Examples Of Effect Of Drugs On Resting Breathingmentioning

confidence: 99%

Assessment of the Effects of Drugs on Respiration

Jordan

1982

British Journal of Anaesthesia

View full text Add to dashboard Cite

Many drugs used in anaesthetic practice such as the opiates, sedatives, barbiturates and volatile anaesthetic agents cause respiratory depression. This often leads to a cautious use of such agents and on occasions this may lead to the administration of a dose of drug which is less than that desired for adequate therapeutic effect. This may often be the case with the administration of opiates for postoperative pain. Consequently, there is a great interest in measuring the respiratory effects of these commonly used drugs both in the laboratory and in the clinical environment, and this interest clearly extends into assessing the efficacy and safety of new compounds and of novel modes of administration of new and conventional agents. Of prime importance in such studies is the development of suitable methods for assessing the respiratory effects of these drug regimes. The methods must be able not only to quantify the degree of respiratory depression, but also detect alterations in the regulation of breathing which may indicate the potential for serious depression to occur. A number of methods are available which fulfil these requirements to varying degrees in different applications. This paper describes and classifies these methods, indicates the applications in which they are most useful and outlines some recent findings. MEASUREMENT OF RESTING BREATHING Ventilation is normally well regulated to ensure blood-gas homeostasis. It is thus of primary importance to investigate the effects of drugs on the regulation of ventilation during resting breathing. Ventilation may be measured or its effectiveness assessed by measurement of blood-gas tensions. Practical measurement of ventilation Methods generally involve either (a) direct measurement of ventilation where the subject is required to use a mouthpiece and nose-clip or tight-fitting

show abstract

Diazepam (Valium) as a Muscle Relaxant During General Anaesthesia: A Pilot Study

Cited by 17 publications

References 9 publications

Effect of Diazepam on Neuromuscular Transmission and its Interaction with Non-Depolarizing Muscle Relaxants

Effect of Diazepam on Neuromuscular Transmission and its Interaction with Non-Depolarizing Muscle Relaxants

Benzoctamine–a Study of the Respiratory Effects of Oral Doses in Human Volunteers and Interactions With Morphine in Mice

Assessment of the Effects of Drugs on Respiration

Contact Info

Product

Resources

About