1982
DOI: 10.1093/bja/54.7.763
|View full text |Cite
|
Sign up to set email alerts
|

Assessment of the Effects of Drugs on Respiration

Abstract: Many drugs used in anaesthetic practice such as the opiates, sedatives, barbiturates and volatile anaesthetic agents cause respiratory depression. This often leads to a cautious use of such agents and on occasions this may lead to the administration of a dose of drug which is less than that desired for adequate therapeutic effect. This may often be the case with the administration of opiates for postoperative pain. Consequently, there is a great interest in measuring the respiratory effects of these commonly u… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
31
0
1

Year Published

1983
1983
2013
2013

Publication Types

Select...
5
4
1

Relationship

0
10

Authors

Journals

citations
Cited by 95 publications
(32 citation statements)
references
References 63 publications
0
31
0
1
Order By: Relevance
“…It is evident from our previous study (Catley et al 1985) that postoperative regional anaesthesia was completely free of hypoxic episodes and might prove to be the ideal form of analgesia in the patient with respiratory disease. If opiates are used, particularly with patientdemand analgesia, then it would seem wise to use a monitor of breathing pattern or Sao2 similar to that used in this study (Jordan 1982). The administration of controlled oxygen concentration appears to be beneficial.…”
Section: Methodsmentioning
confidence: 95%
“…It is evident from our previous study (Catley et al 1985) that postoperative regional anaesthesia was completely free of hypoxic episodes and might prove to be the ideal form of analgesia in the patient with respiratory disease. If opiates are used, particularly with patientdemand analgesia, then it would seem wise to use a monitor of breathing pattern or Sao2 similar to that used in this study (Jordan 1982). The administration of controlled oxygen concentration appears to be beneficial.…”
Section: Methodsmentioning
confidence: 95%
“…The incidence of respiratory depression depends on how it is defmed. 71 The incidence of respiratory depression requiring intervention following conventional doses of intrathecal and epidural opioids is approximately 1%, which is the same as that following conventional dosing of intramuscular and intravenous opioids. 32.33,50,66,72 Early respiratory depression oceurs within two hours of injection of opioid.…”
Section: Respiratory Depressionmentioning
confidence: 99%
“…Apart from the use of anaesthesia [39] and from species differences [16] there are several other possible explanations for these differences.…”
Section: Comparison With Human Studiesmentioning
confidence: 99%