Diatom-inspired skeletonisation of insulin – Mechanistic insights into crystallisation and extracellular bioactivity

Veliz, Diosangeles Soto; Alam, Catharina; Nietzel, Thiago; Wyborski, Rebecca; Rivero-Müller, Adolfo; Alam, Parvez

doi:10.1016/j.colsurfb.2015.05.047

Cited by 4 publications

(3 citation statements)

References 69 publications

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“…The use of diatoms or diatom-inspired/mimetic encapsulating or skeletonizing bodies as carriers for drugs and biomedical compounds has been explored. In addition, diatom biosilica has been used as a drug delivery vehicle through surface modification or coating with heterogeneous materials [103][104][105][106]. The surfaces of natural diatoms (DE) were modified with bioinspired polydopamine (PDA) to create a barrier/gatekeeper for the model drug curcumin (CUR).…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review

Min,

Kim,

Youn

et al. 2024

IJMS

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Diatom biosilica is an important natural source of porous silica, with three-dimensional ordered and nanopatterned structures referred to as frustules. The unique features of diatom frustules, such as their high specific surface area, thermal stability, biocompatibility, and adaptable surface chemistry, render diatoms valuable materials for high value-added applications. These attributes make diatoms an exceptional cost-effective raw material for industrial use. The functionalization of diatom biosilica surface improves its biophysical properties and increases the potential applications. This review focuses on the potential uses of diatom biosilica including traditional approaches and recent progress in biomedical applications. Not only well-studied drug delivery systems but also promising uses on bone regeneration and wound healing are covered. Furthermore, considerable aspects and possible future directions for the use of diatom biosilica materials are proposed to develop biomedical applications and merit further exploration.

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Section: Drug Delivery Systemsmentioning

confidence: 99%

Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review

Min,

Kim,

Youn

et al. 2024

IJMS

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“…diatoms as hemostatic agent for hemorrhage control, showing excellent results in the induction of erythrocyte absorption and aggregation, as well as activation of coagulation in a rat-tail amputation model [89]. Other authors instead have used diatom-inspired approaches for, e.g., the mineral skeletonisation of insulin [90], diverse pollen-like surface patterns [91], the study of mechanical response of diatom-inspired structures [92], and model tools to map and quantify the role of surface topography on cells' fate [93].…”

Section: Delivery Of Other Drugsmentioning

confidence: 99%

Diatom Biosilica in Targeted Drug Delivery and Biosensing Applications: Recent Studies

Zobi

2022

Micro

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Diatoms are single-cell algae encased in a cell wall (named frustule) composed of transparent, biogenic (or opaline) silica with intricate and strikingly regular patterns. Over the past 30 years, these microorganisms have proven to be a valuable replacement for synthetic silica that satisfies numerous pharmaceutical requirements for the realization of drug delivery vectors, biosensing supports and photonic crystals. It is not only the structural features of the diatoms, but also the possibility of chemically modifying the frustule that permits the relatively straightforward transformation of the biosilica into potential devices for biomedical applications. In this short review, we explore the applications of diatoms-derived biosilica in the drug delivery and biosensing fields. Specifically, we consider the use of diatoms for the targeted delivery of anticancer and antibiotic drugs and how the same microalgae are employed in the fabrications of biosensors whose analyte signal response is evaluated via fluorescence and surface-enhanced Raman scattering techniques. We limit our discussion to studies published in the last seven years, with the intention of minimizing possible redundancy with respect to previously published contributions.

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“…Their biomineralization process has also been taken as an inspirational model for the elaboration of synthetic materials and efficient drug carriers [25]. Véliz and coworkers synthetized an insulin delivery system encaged in a larger diatom growth-guided calcium carbonate skeleton [26]. Synthetic mesoporous silica similarly exhibits surface mineralization potential, acting as template tailoring the formation of complex structures [27,28].…”

Section: Introductionmentioning

confidence: 99%

Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems

Delasoie

Zobi

2019

Pharmaceutics

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Unicellular diatom microalgae are a promising natural resource of porous biosilica. These microorganisms produce around their membrane a highly porous and extremely structured silica shell called frustule. Once harvested from living algae or from fossil sediments of diatomaceous earth, this biocompatible and non-toxic material offers an exceptional potential in the field of micro/nano-devices, drug delivery, theranostics, and other medical applications. The present review focused on the use of diatoms in the field of drug delivery systems, with the aim of presenting the different strategies implemented to improve the biophysical properties of this biosilica in terms of drug loading and release efficiency, targeted delivery, or site-specific binding capacity by surface functionalization. The development of composite materials involving diatoms for drug delivery applications is also described.

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Diatom-inspired skeletonisation of insulin – Mechanistic insights into crystallisation and extracellular bioactivity

Cited by 4 publications

References 69 publications

Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review

Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review

Diatom Biosilica in Targeted Drug Delivery and Biosensing Applications: Recent Studies

Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems

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