Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review

Min, Ki Ha; Kim, Dong Hyun; Youn, Sol; Pack, Seung Pil

doi:10.3390/ijms25042023

Cited by 8 publications

(3 citation statements)

References 121 publications

(127 reference statements)

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“…The diatom, with its hierarchical pore structure, offers an extensive, specific surface area, facilitating a heightened liquid absorption rate. Comprising biosilica, diatoms exhibit significant porosity, which is beneficial for blood absorption and fostering accelerated fibroblast differentiation [ 218 ]. Calcium carbonate, utilized in wound dressings, aids in hemostasis.…”

Section: Biominerals and Composite Materials In Regenerative Medicinementioning

confidence: 99%

Biomineral-Based Composite Materials in Regenerative Medicine

Kim,

Ki,

Han

et al. 2024

IJMS

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Regenerative medicine aims to address substantial defects by amplifying the body’s natural regenerative abilities and preserving the health of tissues and organs. To achieve these goals, materials that can provide the spatial and biological support for cell proliferation and differentiation, as well as the micro-environment essential for the intended tissue, are needed. Scaffolds such as polymers and metallic materials provide three-dimensional structures for cells to attach to and grow in defects. These materials have limitations in terms of mechanical properties or biocompatibility. In contrast, biominerals are formed by living organisms through biomineralization, which also includes minerals created by replicating this process. Incorporating biominerals into conventional materials allows for enhanced strength, durability, and biocompatibility. Specifically, biominerals can improve the bond between the implant and tissue by mimicking the micro-environment. This enhances cell differentiation and tissue regeneration. Furthermore, biomineral composites have wound healing and antimicrobial properties, which can aid in wound repair. Additionally, biominerals can be engineered as drug carriers, which can efficiently deliver drugs to their intended targets, minimizing side effects and increasing therapeutic efficacy. This article examines the role of biominerals and their composite materials in regenerative medicine applications and discusses their properties, synthesis methods, and potential uses.

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Section: Biominerals and Composite Materials In Regenerative Medicinementioning

confidence: 99%

Biomineral-Based Composite Materials in Regenerative Medicine

Kim,

Ki,

Han

et al. 2024

IJMS

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“…Additionally, the identification of novel SDV membrane proteins like silicanin [ 58 ], tpSAP1, tpSAP2, and tpSAP3 [ 59 ], along with the discovery of lysine-rich motifs within silaffins [ 60 ], has significantly enhanced our understanding of diatom biosilica formation and its potential for diverse applications. These molecular insights provide a robust foundation for harnessing the unique properties of diatom biosilica and developing groundbreaking practical applications across various fields [ 61 , 62 , 63 , 64 ].…”

Section: Synthesis and Functionalization Approaches For Silica-based ...mentioning

confidence: 99%

Nanoengineered Silica-Based Biomaterials for Regenerative Medicine

Abdelhamid,

Khalifa,

et al. 2024

IJMS

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The paradigm of regenerative medicine is undergoing a transformative shift with the emergence of nanoengineered silica-based biomaterials. Their unique confluence of biocompatibility, precisely tunable porosity, and the ability to modulate cellular behavior at the molecular level makes them highly desirable for diverse tissue repair and regeneration applications. Advancements in nanoengineered silica synthesis and functionalization techniques have yielded a new generation of versatile biomaterials with tailored functionalities for targeted drug delivery, biomimetic scaffolds, and integration with stem cell therapy. These functionalities hold the potential to optimize therapeutic efficacy, promote enhanced regeneration, and modulate stem cell behavior for improved regenerative outcomes. Furthermore, the unique properties of silica facilitate non-invasive diagnostics and treatment monitoring through advanced biomedical imaging techniques, enabling a more holistic approach to regenerative medicine. This review comprehensively examines the utilization of nanoengineered silica biomaterials for diverse applications in regenerative medicine. By critically appraising the fabrication and design strategies that govern engineered silica biomaterials, this review underscores their groundbreaking potential to bridge the gap between the vision of regenerative medicine and clinical reality.

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“…This material is commonly used in various industrial applications due to its advantages and low cost [129,130]. Research has been conducted on wound care technologies inspired by diatoms and biomimetic technologies using diatomite due to their advantages [131]. Adhesives play a crucial role in wound care techniques as they are utilized for wound closure and hemostasis [108,132].…”

Section: Wound Care Techniques Inspired By Diatom and Diatomitementioning

confidence: 99%

Biomimetic Materials for Skin Tissue Regeneration and Electronic Skin

Youn,

Ki,

Abdelhamid

et al. 2024

Biomimetics

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Biomimetic materials have become a promising alternative in the field of tissue engineering and regenerative medicine to address critical challenges in wound healing and skin regeneration. Skin-mimetic materials have enormous potential to improve wound healing outcomes and enable innovative diagnostic and sensor applications. Human skin, with its complex structure and diverse functions, serves as an excellent model for designing biomaterials. Creating effective wound coverings requires mimicking the unique extracellular matrix composition, mechanical properties, and biochemical cues. Additionally, integrating electronic functionality into these materials presents exciting possibilities for real-time monitoring, diagnostics, and personalized healthcare. This review examines biomimetic skin materials and their role in regenerative wound healing, as well as their integration with electronic skin technologies. It discusses recent advances, challenges, and future directions in this rapidly evolving field.

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Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review

Cited by 8 publications

References 121 publications

Biomineral-Based Composite Materials in Regenerative Medicine

Biomineral-Based Composite Materials in Regenerative Medicine

Nanoengineered Silica-Based Biomaterials for Regenerative Medicine

Biomimetic Materials for Skin Tissue Regeneration and Electronic Skin

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