Diastolic dyssynchrony assessment by gated myocardial perfusion-SPECT in subjects who underwent cardiac resynchronization therapy

Alexánderson-Rosas, Erick; Espínola‐Zavaleta, Nilda; Garcia, Ernest; Peix, Amalia; Massardo, Teresa; Pabón, Luz Maritza; Antonio-Villa, Neftalí Eduardo; Carvajal-Juárez, Isabel; Mesquita, Cláudio Tinoco; Jiménez-Heffernan, Amelia; Patel, Chetan; Karthikeyan, Ganesan; Kumar, Alka; Butt, Sadaf; Kalaivani, Mani; Marin, V Terribile Wiel; Morozova, Olga; Páez, Diana

doi:10.1007/s12350-019-01845-2

Cited by 18 publications

(6 citation statements)

References 24 publications

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“…The trial was titled ''Value of intraventricular synchronism assessment by gated SPECT myocardial perfusion imaging in the management of heart failure patients submitted to cardiac resynchronization therapy'' (IAEA VISION-CRT). Several reports on the findings of this trial are already published [2][3][4] and other reports are forthcoming.…”

Section: Introductionmentioning

confidence: 88%

Technical aspects of gated SPECT MPI assessment of left ventricular dyssynchrony used in the VISION-CRT study

Jiménez-Heffernan

Butt

Mesquita

et al. 2021

Journal of Nuclear Cardiology

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contains supplementary material, which is available to authorized users. The authors of this article have provided a PowerPoint file, available for download at SpringerLink, which summarises the contents of the paper and is free for re-use at meetings and presentations. Search for the article DOI on SpringerLink.com. The authors have also provided an audio summary of the article, which is available to download as ESM, or to listen to via the JNC/ASNC Podcast. Funding IAEA Coordinated Research Protocol E1.30.34 funded the VISION-CRT trial.

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Section: Introductionmentioning

confidence: 88%

Technical aspects of gated SPECT MPI assessment of left ventricular dyssynchrony used in the VISION-CRT study

Jiménez-Heffernan

Butt

Mesquita

et al. 2021

Journal of Nuclear Cardiology

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“…All underwent gated-SPECT MPI before and 6 months after CRT, and it was concluded that LV dyssynchrony improvement by gated-SPECT MPI, but not on-target lead placement, predicted clinical outcomes in patients undergoing CRT [22]. In addition, other papers showing the association of septal thickening improvement with reverse remodeling, improvement in LVEF, and reduction of left ventricular dyssynchrony [23], as well as the favorable effect of CRT on LV diastolic dyssynchrony [24] have been also published. Recently, another paper was published on the technical aspects of gated-SPECT MPI assessment of left ventricular dyssynchrony used in the VISION-CRT study [25].…”

Section: Introductionmentioning

confidence: 99%

Intraventricular synchronism assessment by gated-SPECT myocardial perfusion imaging in cardiac resynchronization therapy. Does cardiomyopathy type influence results?

Peix¹,

Padrón²,

Cabrera³

et al. 2020

EJNMMI Res

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Purpose To analyze the evolution post-cardiac resynchronization therapy (CRT) in left ventricular non-compaction (LVNC) cardiomyopathy (CM) patients compared to other types of CM, according to clinical and functional variables, by using gated-SPECT myocardial perfusion imaging (MPI). Methods Ninety-three patients (60 ± 11 years, 28% women) referred for pre-CRT assessment were studied and divided into three groups: 1 (non-ischemic CM with LVNC, 11 patients), 2 (ischemic CM, 28 patients), and 3 (non-ischemic CM, 53 patients). All were studied by a 99mTc-MIBI gated-SPECT MPI at rest pre-CRT implantation and 6 ± 1 months after, including intraventricular dyssynchrony assessment by phase analysis. Quality of life was measured by the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Results No differences in sex, atherosclerotic risk factors other than smoking habit, and MLHFQ results were found among groups. LVNC CM patients were younger, with greater QRS width and lower left ventricular ejection fraction (LVEF) at baseline, but the differences were not significant. No significant differences were found at baseline regarding ventricular function, although end-systolic volume was slightly higher in LVNC CM patients. Mean SRS was significantly higher (p < 0.0001) in ischemic patients (14.9) versus non-ischemic ones (8.7 in group 1 and 9 in group 2). At baseline, LVNC CM patients were significantly more dyssynchronous: Their phase standard deviation (PSD) was higher (89.5° ± 14.2°) versus groups 2 (65.2° ± 23.3°) and 3 (69.7° ± 21.7°), p = 0.007. Although the quality of life significantly improved in all groups, non-ischemic patients (with or without LVNC) showed a higher LVEF increase and volumes reduction at 6 months post-CRT. Dyssynchrony reduced post-CRT in all groups. Nevertheless, those more dyssynchronous at baseline (LVNC CM) exhibited the most significant intraventricular synchronism improvement: PSD was reduced from 89.5° ± 14.2° at baseline to 63.7° ± 20.5° post-CRT (p = 0.028). Six months post-CRT, 89% of patients were responders: 11 (100%) of those with LVNC CM, 25 (86%) of those with ischemic CM, and 47 (89%) of patients with non-ischemic CM. No patient with LVNC CM had adverse events during the follow-up. Conclusion CRT contributes to a marked improvement in non-ischemic CM patients with non-compaction myocardium. Phase analysis in gated-SPECT MPI is a valuable tool to assess the response to CRT.

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Section: Introductionmentioning

confidence: 99%

Intraventricular synchronism assessment by gated - SPECT myocardial perfusion imaging in cardiac resynchronization therapy. Does cardiomyopathy type influence results?

Peix¹,

Padrón²,

Cabrera

et al. 2020

Preprint

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Purpose: To analyse the evolution post-cardiac resynchronization therapy (CRT) in left ventricular non-compaction (LVNC) cardiomyopathy (CM) patients compared to other types of CM, according to clinical and functional variables, by using gated-SPECT myocardial perfusion imaging (MPI).Methods: Ninety-three patients (60 ± 11 years, 28% women) referred for pre-CRT assessment were studied and divided into three groups: 1 (non-ischemic CM with LVNC, 11 patients), 2 (ischemic CM, 28 patients), and 3 (non-ischemic CM, 53 patients). All were studied by a 99mTc-MIBI gated-SPECT MPI at rest pre-CRT implantation, and 6±1 months after, including intraventricular dyssynchrony assessment by phase analysis. Quality of life was measured by the Minnesota Living with Heart Failure Questionnaire (MLHFQ).Results: No differences in sex, atherosclerotic risk factors other than smoking habit, and MLHFQ results were found among groups. LVNC CM patients were younger, with greater QRS width and lower left ventricular ejection fraction (LVEF) at baseline, but the differences were not significant. No significant differences were found at baseline regarding ventricular function, although end-diastolic volume was slightly higher in LVNC CM patients. Mean SRS was significantly higher (p<0.0001) in ischemic patients (14.9) vs. non-ischemic ones (8.7 in group 1 and 9 in group 2). At baseline, LVNC CM patients were significantly more dyssynchronous: their phase standard deviation (PSD) was higher (89.5±14.2 degrees) vs. groups 2 (65.2±23.3 degrees) and 3 (69.7±21.7 degrees), p=0.007. Although the quality of life significantly improved in all groups, non-ischemic patients (with or without LVNC) showed a higher LVEF increase and volumes reduction at 6 months post-CRT. Dyssynchrony reduced post-CRT in all groups. Nevertheless, those more dyssynchronous at baseline (LVNC CM) exhibited the most significant intraventricular synchronism improvement: PSD was reduced from 89.5±14.2 degrees at baseline to 63.7±20.5 degrees post-CRT (p=0.028). Six months post-CRT, 89% of patients were responders: 11 (100%) of those with LVNC CM, 25 (86%) of those with ischemic CM, and 47 (89%) of patients with non-ischemic CM. No patient with LVNC CM had adverse events during the follow-up.Conclusion: CRT contributes to a marked improvement in non-ischemic CM patients with non-compaction myocardium. Phase analysis in gated-SPECT MPI is a valuable tool to assess the response to CRT.

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Diastolic dyssynchrony assessment by gated myocardial perfusion-SPECT in subjects who underwent cardiac resynchronization therapy

Cited by 18 publications

References 24 publications

Technical aspects of gated SPECT MPI assessment of left ventricular dyssynchrony used in the VISION-CRT study

Technical aspects of gated SPECT MPI assessment of left ventricular dyssynchrony used in the VISION-CRT study

Intraventricular synchronism assessment by gated-SPECT myocardial perfusion imaging in cardiac resynchronization therapy. Does cardiomyopathy type influence results?

Intraventricular synchronism assessment by gated - SPECT myocardial perfusion imaging in cardiac resynchronization therapy. Does cardiomyopathy type influence results?

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