Abstract:Electrophile‐directed alkylations in which a chiral, sp3‐hybridized electrophile, dictates the facial attack on a prochiral nucleophile, provides a powerful method of asymmetric induction. The strategy is inherently efficient because the asymmetry of an sp3‐hybridized electrophile is propagated to install two contiguous chiral centers, the first through an SN2 displacement and the second through preferential facial recognition. The two primary modes of topological matching are through steric approach control a… Show more
This review surveys the formation, structure, and properties of metalated isocyanides, a synthetic multi-tool with nucleophilic and electrophilic sites, providing a powerful approach to rapidly access complex molecules.
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