Diastereoisomeric saponins from Albizia julibrissin

Zou, Kun; Tong, Wen-yong; Liang, Hong; Cui, Jinshi; Tu, Guangzhong; Zhao, Yi; Zhang, Ruyi

doi:10.1016/j.carres.2004.10.027

Cited by 63 publications

(40 citation statements)

References 7 publications

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“…These compounds included the six flavonols, quercetin (5), 25) isorhamnetin (6), 26) rhamnetin (7), 27) quercitrin (8), 25) kaempferol (9), 25) and afzelein (10), 28) the five flavons, chrysoeriol (11), 29) apigenin (12), 30) tricin (13), 31) luteolin (14), 32) and amentoflavone (15), 33) the flavanonol, taxifolin (16), 34) the chalcone, isoliquiritigenin (17), 35) the dithiodicarboxylic acid, 3,3′-dithiodipropanoic acid (18), 36) the indole derivative, indole-3-carboxylic acid (19), 37) the alloxazine derivative, 7,8-dimethylalloxazine (20), 38) the phenylpropanoid, (E)-p-coumaric acid (21), 39) and the mono-terpenoid, (6S)-menthiafolic acid (22). 40) Compounds 6, 7, 11-22 were isolated for the first time from the flower of A. julibrissin.…”

Section: Resultsmentioning

confidence: 99%

Flavonol Acylglycosides from Flower of Albizia julibrissin and Their Inhibitory Effects on Lipid Accumulation in 3T3-L1 Cells

2012

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Obesity is a serious health problem worldwide. We investigated the anti-obesity effect of the flower of Albizia julibrissin DURAZZ. (Leguminosae). A 90% EtOH extract of the flower inhibited adipogenesis in 3T3-L1 preadipocytes, as well as the activity of glycerol-3-phosphate dehydrogenase (GPDH) activity. New flavonol acylglycosides (1-4) and eighteen known compounds (5-22) were isolated by bioassay-directed fractionation. These new glycosides were elucidated to be 3″-(E)-p-coumaroylquercitrin (1), 3″-(E)-feruloylquercitrin (2), 3″-(E)-cinnamoylquercitrin (3), and 2″-(E)-cinnamoylquercitrin (4) on the basis of spectroscopic and chemical analysis. These compounds inhibited adipogenesis in 3T3-L1 preadipocytes. In particular, 2 exhibited potent inhibitory effects on triglyceride accumulation. Furthermore, GPDH activity was inhibited by 2. Additionally, 2 inhibited glucose uptake in 3T3-L1 adipocytes. These results indicate that the 90% EtOH extract and compounds isolated from the flower of A. julibrissin inhibit adipogenesis in 3T3-L1 preadipocytes and may have anti-obesity effect through the inhibition of preadipocyte differentiation.

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Section: Resultsmentioning

confidence: 99%

Flavonol Acylglycosides from Flower of Albizia julibrissin and Their Inhibitory Effects on Lipid Accumulation in 3T3-L1 Cells

2012

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“…The hydrolysis and the detection of sugars in hydrolyzed products were carried out according to procedures described in the literature [34].…”

Section: Acid Hydrolysismentioning

confidence: 99%

New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes

Zou

Wang

et al. 2007

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Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5β-furost-Δ 25(27) -en-1β,2β,3β,4β,5β,7α,22ξ,26-octaol-6-one-26-O-β-D-glucopyranoside (1) and 5β-furost-Δ 25(27) -en-1β,2β,3β,4β,5β,6β, 7α,22ξ,26-nonaol-26-O-β-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 μg/mL.

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“…Their experiments also showed that avicins prevented chemical-induced carcinogenesis in mice, and strongly inhibited TNF-induced NF-kappa B. This paper reports the isolation and structure elucidation of compound 1, an analogue of Julibroside J 1 (2). Compound 1 showed significant cytotoxic activity against the Bel-7402 cancer cell line by the SRB (Sulforhodamine B) method.…”

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confidence: 90%

“…(Leguminosae) is recorded in the Chinese Pharmacopoeia as a sedative and anti-inflammatory agent, and specified to treat injuries from falls and remove carbuncles. 1) In the preceding studies, [2][3][4] we reported the isolation and structure elucidation of some complicated and cytotoxic julibrosides from the stem bark of this plant. Recently, Haridas et al, [5][6][7] have reported the anti-cancer actions of avicins, a family of triterpenoid saponins obtained from the Australian desert tree Acacia victoriae (Leguminosae: Mimosoideae).…”

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confidence: 99%