Diarylheptanoids from Alnus nepalensis attenuates LPS-induced inflammation in macrophages and endotoxic shock in mice

Saxena, Archana; Yadav, Deepti; Maurya, Anil Kumar; Kumar, Anant; Mohanty, S. R.; Gupta, Madan M.; Lingaraju, Madhu Cholenahalli; Yatoo, Mohd Iqbal; Thakur, Uttam S.; Bawankule, Dnyaneshwar Umrao

doi:10.1016/j.intimp.2015.12.002

Cited by 21 publications

(18 citation statements)

References 31 publications

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“…One of the approaches that are employed to determine immunological effects of medicinal plants or their products is assessment of cytokine production in vitro and in vivo (Saxena et al, 2016). Cytokines are low molecular weight glycoproteins produced by a number of cell types, predominantly leukocytes that regulate immunity, inflammation and hematopoiesis (Oppenheim, 2013).…”

Section: Introductionmentioning

confidence: 99%

Modulation of cytokine production from cultured mononuclear cells of leukemia patients by Hypericum triquetrifolium Turra methanolic extract

Ad’hiah

Ibraheem

Abbood

2018

Arab Journal of Basic and Applied Sciences

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The effect of Hypericum triquetrifolium Turra (Family: Hypericaceae) methanolic extract on an in vitro cytokine release (IL-2, IL-4, IL-10, IL-17A and IFN-c) from cultured mononuclear cells was determined. The cells were obtained from acute lymphoblastic (ALL) and acute myelogenous leukemic (AML) Iraqi patients. Two concentrations (1.146 and 1.719 mg/ml) of the extract were tested. They were correspondent to 20 and 30%, respectively of the plant IC 50 (5.73 mg/ml). Chemical analysis of the extract showed its richness in flavonoids (115.73 mg/ ml). Assessments of cytokine levels in supernatants of cultured cells revealed that ALL, AML or control cells responded differently to the plant extract in their production of IL-2, IL-10, IL-17A and IFN-c, but leukemic cells were better than control cells in their response, while there was no effect on IL-4 production. The results suggested that H. triquetrifolium methanolic extract exerted immunomodulatory effects on cultured cells.

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Section: Introductionmentioning

confidence: 99%

Modulation of cytokine production from cultured mononuclear cells of leukemia patients by Hypericum triquetrifolium Turra methanolic extract

Ad’hiah

Ibraheem

Abbood

2018

Arab Journal of Basic and Applied Sciences

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“…Diarylheptanoids are a group of natural products extensively investigated for a variety of bioactivities. They have been reported to exhibit anti-inflammatory, antioxidant, cytotoxic, estrogenic, antimicrobial, antiparasitic, hepatoprotective, neuroprotective and many other activities (Dinić et al 2014;Novaković et al 2014Novaković et al , 2015Huang et al 2016;Saxena et al 2016;Sueth-Santiago et al 2016;Suksen et al 2016;Thongon et al 2017). In our previous work, it was demonstrated that diarylheptanoids are powerful indicators in the identification of and discrimination between the species A. glutinosa and A. incana (Vidaković et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Inter- and intraspecific variability of selected diarylheptanoid compounds and leaf morphometric traits in Alnus glutinosa and Alnus incana

et al. 2018

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The reliability of diarylheptanoids as chemotaxonomic markers at inter- and intraspecific levels has been investigated. Six diarylheptanoids were quantified in bark ethanol extracts of fourAlnusspp. populations by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The populations described here aslocus classicus Alnus glutinosa(I) andlocus classicus Alnus incana(III) are clearly differentiated. Compared to population I, individuals in population III have higher extract yields and hirsutanonol-5-O-β-D-glucopyranoside content and lower contents of hirsutanonol, rubranoside A and oregonin. Individuals from neighboring populations ofA. glutinosa(II) andA. incana(IV) share similar contents of hirsutanonol. All the studied populations exhibit a high intrapopulation variability of the selected diarylheptanoids; they have a heterogeneous chemotype and they partially overlap. The geographical proximity of populations II and IV increases their chemical similarity. Principal component analysis (PCA) clearly shows that the biggest dispersion of individuals lies within population IV. The reason for its heterogeneity might be its physical proximity to population II, i.e. the appearance of hybrids. Also, geometric morphometrics of leaves was performed as a screening criterion for spontaneous hybrids.

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“…In the chemical studies of A. officinarum , some bioactive components of diarylheptanoids (An, Xu, Zou, & Yang, ; Itokawa, Morita, Midorikawa, Aiyama, & Morita, ; Shin et al, ; Uehara et al, ), flavonoids (Guo et al, ; Shin, Joo, & Kim, ), phenylpropanoids (Ly et al, ; Ly, Shimoyamada, Kato, & Yamauchi, ), volatile oil (Luo, Cai, Zhang, & Mo, ), neolignans (Ly et al, ) and glycosides (Ly, Yamauchi, Shimoyamada, & Kato, ) have been reported. Pharmacological research found that the diarylheptanoids had many bioactivities (Hu & Wang, ; Park et al, ; Saxena et al, ; Sudsai, Wattanapiromsakul, & Tewtrakul, ; Yin, Luo, & Kong, ).…”

Section: Introductionmentioning

confidence: 99%

“…It has been suggested that inflammation might be connected with glycerophospholipids metabolism. Although there have been numerous studies on anti‐inflammatory activities of diarylheptanoids (Hu & Wang, ; Lee et al, ; Lee, Kim, & Ryu, ; Saxena et al, ; Yadav et al, ), the relationships between anti‐inflammatory activities and structures of diarylheptanoids are not clear. Recent study in our laboratory suggested that the anti‐inflammatory activity of diphenylheptane A is associated with glycerophospholipids (She, Zheng, Xiao, Wu, & Feng, ).…”

Section: Introductionmentioning

confidence: 99%

Anti‐inflammatory activities and glycerophospholipids metabolism in KLA‐stimulated RAW 264.7 macrophage cells by diarylheptanoids from the rhizomes of Alpinia officinarum

Zhang

Zhao²,

Zhu

et al. 2017

Biomedical Chromatography

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Alpinia officinarum is used for its anti-inflammatory activity historically in China. Diarylheptanoids isolated from A. officinarum play important biological roles in the prevention and treatment of inflammatory disorders. Seven diarylheptanoids (1-7) were isolated from A. officinarum. The cell viabilities and anti-inflammatory activities of diarylheptanoids were evaluated by MTT assay and tumor necrosis factor-α production in Kdo2-lipid A-stimulated RAW 264.7 cells in vitro. The relationships between their anti-inflammatories and structure-activities are discussed. The results indicated that compounds 1 and 3-7 had significant anti-inflammatory activities. The relationships between inflammation and phospholipids metabolism were elucidated by multivariate data analysis. Twenty-two potential biomarkers were identified in inflammatory group vs. blank group, and 11 potential biomarkers were identified for inflammatory group vs. drug-treatment groups. Ten common phospholipids were characterized. On the basis of a previous study in our laboratory, we found that phosphatidylethanolamine (18:0/18:1) might be the important glycerophospholipid biomarker in inflammation. In this study, we firstly combined anti-inflammatory activities and glycerophospholipids changes of traditional Chinese medicine. This work suggests that the anti-inflammatory activities of diarylheptanoids might be significantly related to glycerophospholipids and could provide a useful database for investigating the anti-inflammatory effects of traditional Chinese medicine.

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Diarylheptanoids from Alnus nepalensis attenuates LPS-induced inflammation in macrophages and endotoxic shock in mice

Cited by 21 publications

References 31 publications

Modulation of cytokine production from cultured mononuclear cells of leukemia patients by Hypericum triquetrifolium Turra methanolic extract

Modulation of cytokine production from cultured mononuclear cells of leukemia patients by Hypericum triquetrifolium Turra methanolic extract

Inter- and intraspecific variability of selected diarylheptanoid compounds and leaf morphometric traits in Alnus glutinosa and Alnus incana

Anti‐inflammatory activities and glycerophospholipids metabolism in KLA‐stimulated RAW 264.7 macrophage cells by diarylheptanoids from the rhizomes of Alpinia officinarum

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