Anti‐inflammatory activities and glycerophospholipids metabolism in KLA‐stimulated RAW 264.7 macrophage cells by diarylheptanoids from the rhizomes of <scp><i>Alpinia officinarum</i></scp>

Zhang, Guogai; Zhao, Lifang; Zhu, Jiancheng; Feng, Yifan; Wu, Xia

doi:10.1002/bmc.4094

Cited by 12 publications

(16 citation statements)

References 47 publications

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“…Phosphatidylethanolamine (PE), one product of glycerophospholipid metabolism, is produced through the decarboxylation of Phosphatidylserine (PS) by PS Decarboxylase (PSD) [15]. PS was reported to regulate inflammation and tumor necrosis factor-α (TNF-α) production in Kdo2-lipid A-stimulated RAW 264.7 cells in vitro [16]. Lysophosphatidylethanolamine (LysoPE), the hydrolysate of PE, contributes to cell proliferation and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Exploration of The Mechanism of Qianliexin Capsule Against Chronic Nonbacterial Prostatitis Using Metabolomicsv

Zang¹,

Y²,

Zhang³

et al. 2021

COS

124

101

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1.1. Objective: Qianliexin Capsule (QLX), a traditional Chinese medicine, has been widely used to treat Chronic Nonbacterial Prostatitis (CNP) in China. Here, metabolic profiling was utilized to clarify the bio-targets of QLX in CNP treatment. Methods:An estradiol-induced prostatitis rat model was used to mimic the hormonal imbalance-induced CNP. The urine and serum were collected to analyze metabolic profiles by ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS). Results:An anti-inflammatory role for QLX was seen in the estradiol-induced prostatitis rats, and the Lower Urinary Tract Symptoms (LUTS) were relieved by QLX. The unique metabolic profiling in CNP was significantly changed by addition of QLX. Thirty-nine metabolites identified in serum and urine, that are involved in multiply pathways, were significantly reversed by QLX in the CNP rats. Among them, glycerophospholipid metabolism, sphingolipid metabolism and fructose and mannose metabolic pathways were the most significantly influenced by QLX and were closely associated with the anti-inflammatory role of QLX in CNP. Conclusion: The changed metabolic profile after QLX addition may be associated with the pharmacologic function of QLX in CNP.

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Section: Discussionmentioning

confidence: 99%

Exploration of The Mechanism of Qianliexin Capsule Against Chronic Nonbacterial Prostatitis Using Metabolomicsv

Zang¹,

Y²,

Zhang³

et al. 2021

COS

124

101

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“…Glycerophospholipid metabolism reportedly played an important role in many chronic inflammatory diseases including psoriasis ( 39 ), Behçet’s disease ( 40 ), and arteriosclerosis ( 41 ). It has been reported that glycerophospholipids might be significantly related to the anti‐inflammatory activities of diarylheptanoids ( 42 ). Taken together, our data indicated CSD led to chronic inflammation in rats.…”

Section: Discussionmentioning

confidence: 99%

Multi-Omics Analysis Reveals the Systematic Relationship Between Oral Homeostasis and Chronic Sleep Deprivation in Rats

Chen

Yao

et al. 2022

Front. Immunol.

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Sleep disorders were associated with oral health. Inflammation has especially been thought to be a key factor in linking oral diseases and sleep deficiency. However, how chronic sleep deprivation (CSD) affects oral homeostasis, particularly oral inflammation and oral microbiota, is still unknown. This study aimed to uncover the systematic relationship between oral homeostasis and CSD in rats. The metabolomics in serum, proteomics in the tongue tissues, and microbiome analysis in the oral cavity in CSD rats were performed. Multi-omics data integration analysis was performed to uncover the systematic relationship between oral homeostasis and CSD through the weighted correlation network analysis. We found that CSD could lead to oral inflammation in rats. CSD significantly increased systemic inflammation by enhancing the serum levels of IL-1β, IL-6 and inhibiting the serum level of IL-10. Serum levels of adrenocorticotropin hormone, corticosterone, and triiodothyronine were increased in CSD rats, and the steroid hormone biosynthesis pathway was also found to be involved in the perturbation resulting from CSD, together suggesting the activation of the hypothalamic-pituitary-adrenocortical and hypothalamic‐pituitary‐thyroid axis. CSD led to changes of oral microbiota composition, and g_Acinetobacter, Candidatus Chryseobacterium massiliae, and g_Moraxella were significantly correlated with multiple proteins in bacterial invasion of epithelial cells pathway, which may partially responsible for oral inflammation resulting from CSD. The changes of proteomic profiling expression caused by CSD in tongue tissues were mainly enriched in neurodegenerative diseases pathways and immune/inflammation-related pathways. Multi-omics analysis indicated that the inflammatory response-related modules were significantly correlated with the neurodegenerative disease-related module suggesting a possible link between neurodegenerative diseases and oral inflammation. Together, CSD induced oral inflammation and subtle changes on oral microbiota. Our study is helpful to further understand the role that oral homeostasis plays in the process by which CSD affects human health and disease.

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“…50 Moreover 48, 50 and 51 displayed moderate inhibitory activity against TNF-α production with 38, 35 and 37% rates respectively at 0.06 mg/mL in Kdo2-lipid (KL) A-stimulated RAW 264.7 macrophages. 60 The numerous studies cited here show that Alpinia officinarum is an important source of diarylheptanoids with proven anti-inflammatory properties.…”

Section: Linear Natural Diarylheptanoidsmentioning

confidence: 89%

“…The same team reported latter that 41 acted against TNF- expression with 43% inhibition rate at 0.05 mg/mL (cell viability >80%) in KLA-stimulated RAW 264.7 macrophages. 60 Following preliminary molecular docking studies, 41 was also proved by Elgazar's team 59 to exhibit cytotoxicity with an IC50 value 26.6 µg/mL and anti-inflammatory activities against IL-1, IL-6 and TNF- expression with 83, 65 and 89 % inhibition rates respectively at 10 µg/mL in LPSinduced HepG2 cells. Investigations on -methoxyketone 42 according to the same experiments than hydroxyketone 41 showed better anti-inflammatory activity with PG biosynthesis inhibition IC50 value of 2.3 µM 50 and reduction of mice TPA-induced ear inflammatory edema with ID50 value of 0.9 µmol/ear (compared to indomethacin : ID50 = 0.9 µmol/ear).…”

Section: Linear Natural Diarylheptanoidsmentioning

confidence: 95%

“…59 Moreover, 39 displayed significant inhibitory activity against TNF-α production with 54% rate at 0.02 mg/mL (concentration for which cell viability of diarylheptanoid 39 was more than 80 % by MTT assay) in Kdo2lipid (KL) A-stimulated RAW 264.7 macrophages. 60 In 1982, diarylheptanoids 40 and 41 were proved to inhibit PG biosynthesis with IC50 values of 2.0 and 4.4 M respectively in the same range than indomethacin. 50 Hydroxyketone 41 was thereafter comprehensively evaluated for its anti-inflammatory activity.…”

Section: Linear Natural Diarylheptanoidsmentioning

confidence: 99%

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Anti-inflammatory activity of naturally occuring diarylheptanoids – A review

Vanucci-Bacqué

Bedos‐Belval

2021

Bioorganic & Medicinal Chemistry

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Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, if it becomes uncontrolled, inflammation may result in autoimmune or auto inflammatory disorders, neurodegenerative diseases or cancers. The currently available anti-inflammatory drug therapy is often not successful or induces severe side effects. Thus, the search of new therapeutic options for the treatment of inflammation is highly required. Medicinal plants have been an interesting source for obtaining new active compounds. Diarylheptanoids characterized by a 1, 7-diphenylheptane structural skeleton, are a class of secondary plant metabolites that have gained increasing interest over the last few decades due to a wide variety of biological activities. This review covers 182 natural linear or macrocyclic diarylheptanoids described in the period of 1982 to 2020 with anti-inflammatory activities evaluated using quantified in vitro and/or in vivo assays. All of these data highlight the pharmacological potential of these natural compounds to act as anti-inflammatory drugs.

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Anti‐inflammatory activities and glycerophospholipids metabolism in KLA‐stimulated RAW 264.7 macrophage cells by diarylheptanoids from the rhizomes of Alpinia officinarum

Cited by 12 publications

References 47 publications

Exploration of The Mechanism of Qianliexin Capsule Against Chronic Nonbacterial Prostatitis Using Metabolomicsv

Exploration of The Mechanism of Qianliexin Capsule Against Chronic Nonbacterial Prostatitis Using Metabolomicsv

Multi-Omics Analysis Reveals the Systematic Relationship Between Oral Homeostasis and Chronic Sleep Deprivation in Rats

Anti-inflammatory activity of naturally occuring diarylheptanoids – A review

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